Filament structure found to activate and regulate CRISPR-Cas "protein scissors"
CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, al.....»»
Moths may use disco gene to regulate day/night cycles
How does one species become two? If you're a biologist, that's a loaded question. The consensus is that, in most cases, the process of speciation occurs when individuals from a single population become geographically isolated. If they remain separate.....»»
Dual protein analysis approach provides potential way to slow cancer growth
Fighting cancer effectively often involves stopping cancer cells from multiplying, which requires understanding proteins that the cells rely on to survive. Protein profiling plays a critical role in this process by helping researchers identify protei.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
New genetic sensor for DNA methylation discovered
DNA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and is a major way that DNA is epigenetically marked. Epigenetic modifications can act as on–off switches to regulate gene expression and hel.....»»
The Quantum Mechanics of the Greenhouse Effect
Carbon dioxide’s powerful heat-trapping effect has been traced to a quirk of its quantum structure. The finding may explain climate change better than any computer model......»»
Langbeinites show talents as 3D quantum spin liquids
A 3D quantum spin liquid has been discovered in the vicinity of a member of the langbeinite family. The material's specific crystalline structure and the resulting magnetic interactions induce an unusual behavior that can be traced back to an island.....»»
Researchers achieve first CRISPR-based genome editing in Nile grass rats
A team of researchers at Michigan State University has discovered a set of methods that enabled the first successful CRISPR-based genome editing in Nile grass rats......»»
New "chiral vortex" of light allows chemists to "see" molecules through the mirror
An entirely new structure of light is helping to measure chirality in molecules more accurately and robustly than ever before, in a major potential step for the pharmaceutical industry......»»
Research unravels dual role of membrane protein in rice ethylene signal transduction
A research team, led by Professor Zhang Jinsong from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences, revealed insights into the mechanism by which the membrane protein MHZ3 collaborates with the ethylene.....»»
Vulnerability prioritization is only the beginning
To date, most technology solutions focused on vulnerability management have focused on the prioritization of risks. That usually took the shape of some risk-ranking structure displayed in a table with links out to the CVEs and other advisory or threa.....»»
A small molecular glue that increases P53 level and suppresses tumor growth in vivo
Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, and there has been a lac.....»»
Novel silica nonwoven fabric scaffold enhances understanding of cell-to-cell interactions
Communication and coordination among different cells are fundamental aspects that regulate many functions in our body. This process, known as paracrine signaling, involves the release of signaling molecules by a cell into its extracellular matrix (EC.....»»
App Store VP departing Apple amid broader restructuring
Apple’s App Store vice president is leaving the company in October, according to a new report from Bloomberg. The structure of the App Store team is also being split into two teams, a change implemented by Phil Schiller in response to the ever-.....»»
Survival tactics: AI-driven insights into chromatin changes for winter dormancy in axillary buds
Evolution has enabled plants to survive under adverse conditions. The winter bud of a plant is a crucial structure that establishes adaptability. Depending on environmental and intrinsic conditions, buds can transition between growth and dormancy. Th.....»»
Cryo-ET study elucidates protein folding helpers in their natural environment
Cryo-electron tomography (cryo-ET), can be used to visualize and analyze cellular structures in their natural environment. Researchers at the MPI of Biochemistry in Martinsried and the University Medical Center Göttingen have now used cryo-ET to stu.....»»
Comparing methods for extracting edible protein from mealworms
Edible insects are emerging as an alternative protein source that has various benefits compared with conventional animal sources. New research published in the Journal of Food Science compared four different methods for extracting protein from mealwo.....»»
Civilization VII hands-on: This strategy sequel rethinks the long game
Classic turn-based gameplay meets a radical rethink of the overall structure. Enlarge / Firaxis has upped the ante on presentation for the cities. It's still a bit abstract and removed, but they have more vibrancy, detail, and mo.....»»
Researchers teach artificial intelligence about frustration in protein folding
Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial intelligence (AI) technology has made it possible to predict.....»»
Pore structure characteristics found to influence carbon mineralization under conservation tillage
Soil aggregates are the basic units of soil structure and serve as a reservoir for soil carbon, playing a crucial role in the carbon cycle of ecosystems. The pore characteristics of soil aggregates influence the mineralization of soil organic carbon......»»
Neutrons illuminate environmental and biological mysteries
Neutron techniques have long been valued in various scientific fields for their ability to penetrate materials without altering their structure. However, their use in environmental and biological sciences has been limited. Complex systems like soil-w.....»»