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A small molecular glue that increases P53 level and suppresses tumor growth in vivo

Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, and there has been a lac.....»»

Category: topSource:  pcmagAug 22nd, 2024

Here’s How Long the iOS 17.7 Update Takes

Apple’s new iOS 17.7 update is a small point upgrade, but it could take quite a bit of time to install on your iPhone. If you’re moving your iPhone from iOS 17.6.1 to iOS 17.7, you get the shortest list of changes and the smallest download size......»»

Category: mobileSource:  gottabemobileRelated News5 min. ago

Urgent conservation efforts needed: Possible extirpation of the threatened Malagasy poison frog Mantella cowanii

New research highlights the precarious status of one of Madagascar's most threatened amphibians, the harlequin mantella (Mantella cowanii), revealing small population sizes and the possible extirpation of the species from several of its historic habi.....»»

Category: topSource:  physorgRelated News4 hr. 6 min. ago

Paying attention to errors can improve fused remote monitoring of lakes, researchers say

Lakes can tip the scales from healthy to potential environmental hazard quickly when they become eutrophic. In this state, an abundance of nutrients accelerates algae growth, which then crowd the water's surface and block light from reaching organism.....»»

Category: topSource:  physorgRelated News4 hr. 6 min. ago

This speedy RAM is a world’s first, but the even faster DDR5-10000 is coming

These new RAM kits from Asgard push performance to the next level, but the company already has plans for five-digit RAM speeds in the future......»»

Category: topSource:  digitaltrendsRelated News4 hr. 6 min. ago

Trends and dangers in open-source software dependencies

A C-suite perspective on potential vulnerabilities within open-source dependencies or software packages reveals that, while remediation costs for dependency risks are perilously high, function-level reachability analysis still offers the best value i.....»»

Category: securitySource:  netsecurityRelated News14 hr. 6 min. ago

Biden moves to crack down on Shein and Temu, slow shipments into US

Rapid growth of Temu and Shein threatens US businesses and consumers, Biden says. Enlarge (credit: NurPhoto / Contributor | NurPhoto) The Biden administration has proposed rules that could make it more costly for Chinese.....»»

Category: topSource:  arstechnicaRelated NewsSep 13th, 2024

Trees in tropical logged forests release carbon at greater rate despite faster growth, study finds

Tree stems in tropical forests recovering from logging produce carbon dioxide at a greater rate than those in unlogged forests, according to a new study from the University of Leicester......»»

Category: topSource:  physorgRelated NewsSep 13th, 2024

Remembering where your meals came from key for a small bird’s survival

For small birds, remembering where the food is beats forgetting when it's gone. Enlarge (credit: BirdImages) It seems like common sense that being smart should increase the chances of survival in wild animals. Yet for a.....»»

Category: topSource:  arstechnicaRelated NewsSep 13th, 2024

Earth to have new mini-moon for two months

A pair of asteroid dynamics researchers from Universidad Complutense de Madrid Ciudad Universitaria have found that a small asteroid will make one orbit around the Earth starting this month before departing back into other parts of the solar system......»»

Category: topSource:  physorgRelated NewsSep 13th, 2024

Over 2 million acres of floodplain development occurred in US in last two decades, study finds

A nationwide analysis of community-level floodplain development found that over two-million acres of floodplain were developed over the past two decades across the United States, with roughly half of all new floodplain housing built in Florida......»»

Category: topSource:  physorgRelated NewsSep 13th, 2024

Cyber insurance set for explosive growth

Cyber insurance is poised for exponential growth over the coming decade, but it remains a capital-intensive peril that requires structural innovation, according to CyberCube. The mid-range projection suggests that the US standalone cyber insurance ma.....»»

Category: securitySource:  netsecurityRelated NewsSep 13th, 2024

Over two-million acres of floodplain development occurred in US in last two decades, study finds

A nationwide analysis of community-level floodplain development found that over two-million acres of floodplain were developed over the past two decades across the United States, with roughly half of all new floodplain housing built in Florida......»»

Category: topSource:  physorgRelated NewsSep 12th, 2024

New technique boosts mutation rates in fruit flies for genetics research

A new technique, TF-High-Evolutionary (TF-HighEvo), allows large-scale assessment of de-novo mutations in multicellular organisms. Developed in collaboration with researchers from the European Molecular Biology Laboratory (EMBL) and the Friedrich Mie.....»»

Category: topSource:  physorgRelated NewsSep 12th, 2024

Researchers achieve efficient electro-oxidation of glycerol to formate under room temperature

Glycerol is a key byproduct of biodiesel fabrication, and its production has increased proportionally with the growth of biodiesel production. Glycerol electrooxidation is considered as an innovative strategy due to its low theoretical potential and.....»»

Category: topSource:  physorgRelated NewsSep 12th, 2024

College students" mental health improving, more finding support

The latest annual Healthy Minds Study, which surveyed 100,000-plus college students from 200 universities across the United States, has good news to report: There are decreases in symptoms of anxiety, depression and thoughts of suicide, and increases.....»»

Category: topSource:  physorgRelated NewsSep 12th, 2024

Microbe dietary preferences found to influence effectiveness of carbon sequestration in deep ocean

The movement of carbon dioxide (CO2) from the surface of the ocean, where it is in active contact with the atmosphere, to the deep ocean, where it can be sequestered away for decades, centuries, or longer, depends on a number of seemingly small proce.....»»

Category: topSource:  physorgRelated NewsSep 12th, 2024

Discovery about ice layer formation in ice sheets can improve sea level rise predictions

A newly discovered mechanism for the flow and freezing of ice sheet meltwater could improve estimates of sea level rise around the globe......»»

Category: topSource:  physorgRelated NewsSep 12th, 2024

Catalyzing environmental cleanup: A highly active and selective molecular catalyst and electrified membrane

Some chemicals create environmental problems; others, fortunately, can help clean them up. Chemists from Yale University and their colleagues have developed an electrochemical catalyst and membrane that offers an efficient and sustainable way to trea.....»»

Category: topSource:  physorgRelated NewsSep 12th, 2024

2025 VW Taos refresh gains additional power, design tweaks inside and out

The 2025 refresh is the first time VW has significantly updated the small crossover since it joined the lineup in 2021......»»

Category: topSource:  autonewsRelated NewsSep 12th, 2024

Ozone pollution reduces yearly tropical forest growth by 5.1%, study finds

Ozone gas is reducing the growth of tropical forests—leaving an estimated 290 million tonnes of carbon uncaptured each year, new research shows......»»

Category: topSource:  physorgRelated NewsSep 12th, 2024