Zeroing in on the workings of tumor suppressor protein p53, the "guardian of the genome"
The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and cell death. Now, FMI resea.....»»
Snakes on a plate: Pythons touted as protein alternative
In a warehouse in the lush humid farmlands of central Thailand, thousands of pythons lie coiled in containers, rearing and striking at the glass as people pass by......»»
Lab develops smallest free-floating bubbles for medical imaging
Bioengineering researchers at Rice University have developed ultrasmall, stable gas-filled protein nanostructures that could revolutionize ultrasound imaging and drug delivery......»»
Big boost for new epigenetics paradigm: CoRSIVs, first discovered in humans, now found in cattle
A study published in Genome Biology opens new possibilities to improve production efficiency in the cattle industry and potentially animal agriculture more broadly. A team of researchers at Baylor College of Medicine, Cornell University and the USDA.....»»
3D genome extracted from "freeze-dried" woolly mammoth
About 52,000 years ago, the skinned hide of a Siberian woolly mammoth was exposed to conditions so frigid that it spontaneously freeze-dried, locking its DNA fragments into place......»»
Evolutionary biologists investigate how plant cold specialists can adapt to the environment
Plant cold specialists like the spoonworts have adapted well to the cold climates of the Ice Ages. As cold and warm periods alternated, they developed a number of species that also resulted in a proliferation of the genome......»»
Novel protein found to inhibit activity of CRISPR-Cas system
In a study published in Nature on July 3, researchers from the Institute of Biophysics of the Chinese Academy of Sciences and the University of Toronto, Canada, discovered a novel anti-CRISPR protein called AcrIF25, which inhibits the activity of the.....»»
Opening the right doors: New work reveals "jumping gene" control mechanisms
International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents t.....»»
Genomic insights into adaptation to bipedal saltation and desert-like habitats of jerboas
Jerboas are a lineage of small rodents displaying atypical mouse-like morphology with elongated strong hindlimbs and short forelimbs. A research team has recently sequenced and reported the chromosome-scale genome of the Mongolian five-toed jerboa (O.....»»
Team investigates chemical modifications to gain deeper insights into genetic regulation mechanisms
University of North Carolina at Chapel Hill researchers have determined whether a specific chemical modification of a protein that packages the genome called a histone affects gene activity and cell proliferation, according to the paper, "Drosophila.....»»
Unexpected phage protein function discovered in bacteria battle
An unexpected find has enabled important progress to be made in the battle against harmful bacteria. An international team of researchers, led by Professor Peter Fineran from the University of Otago, investigated a particular protein used by bacteria.....»»
Tiny TnpB: The next-generation genome editing tool for plants unveiled
Genome editing stands as one of the most transformative scientific breakthroughs of our time. It allows us to dive into the very code of life and make precise modifications. Imagine being able to rewrite the genetic instructions that determine almost.....»»
Team develops new one-step method to make multiple edits to a cell"s genome
Genome editing has become a widely adopted technology to modify DNA in cells, allowing scientists to study diseases in the lab and develop therapies that repair disease-causing mutations. However, with current approaches, it's only possible to edit c.....»»
Complete genome and toxin genes of the microalgae from the Oder River disaster decoded
In the summer of 2022, around 1,000 tons of fish, mussels and snails died in the River Oder. Although the disaster was manmade, the immediate cause of death was the toxin of a microalgae with the scientific collective name Prymnesium parvum, often re.....»»
A genome-wide screen in live hosts reveals new secrets of parasite infection
Apicomplexan parasites are a common cause of disease, infecting hundreds of millions of people each year. They are responsible for spreading malaria; cryptosporidiosis—a severe childhood diarrheal disease; and toxoplasmosis—a disease that endange.....»»
Intracellular mechanisms shown to promote spread of deadly bacterial infection
Northwestern Medicine investigators have discovered novel protein mechanisms that promote the rapid spread of Vibrio vulnificus, a rare but lethal bacteria that can cause vibriosis and sepsis, according to findings published in the Proceedings of the.....»»
New method enables amplifiable protein identification from trace samples
In a study published in the journal National Science Review, researchers developed an amplifiable protein identification method called "AmproCode.".....»»
Innovative use of hyperspectral data and DCGANs enhances rice protein content estimation
Rice (Oryza sativa L.) is a crucial crop feeding over half of the global population. The demand for high-quality, protein-rich rice is rising, making accurate grain protein content (GPC) estimation vital for breeding superior varieties......»»
Novel strategy proposed for selectively targeting G-quadruplex at specific genome loci
DNA G-quadruplexes (G4s) are a type of quadruple helix structure formed by a continuous guanine-rich DNA sequence. Although DNA G4s are thought to be involved in various biological processes, in many cases their causative effects are largely unclear.....»»
Novel protein involved in mitochondrial gene expression identified
Researchers at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet have characterized a novel GTPase involved in ribosome production in mitochondria. The study, published in Nature Communications, provides new insights into.....»»
Scientists investigate fast reaction dynamics in synthetic molecules immobilized in porous protein cages
Immobilizing small synthetic molecules inside protein crystals proves to be a promising avenue for studying intermediate compounds formed during chemical reactions, report scientists from Tokyo Tech. By integrating this method with time-resolved seri.....»»