Zeroing in on the workings of tumor suppressor protein p53, the "guardian of the genome"
The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and cell death. Now, FMI resea.....»»
Parasite engineered to deliver therapy proteins to nerve cells
An international team of neurobiologists has developed a way to use a parasite to deliver protein therapies through the blood–brain barrier to treat nerve cell disorders. In their study published in Nature Microbiology, the group engineered the par.....»»
Developing new methods for targeted protein degradation
Northwestern Medicine scientists have developed a new, more precise method to target proteins implicated in certain types of cancer, according to a study published in Nature Chemical Biology......»»
Avocado genome assembled: Uncovering disease resistance and fatty acid secrets
The avocado, celebrated for its nutritious unsaturated fats and distinctive flavor, encounters notable agricultural challenges, particularly its vulnerability to diseases that can drastically reduce fruit quality and yield......»»
Mass breeding of desert locusts unlocks new food source
Mass breeding of desert locusts in a controlled environment could provide a sustainable source of protein for animals and humans as well as business opportunities in Sub-Saharan Africa, researchers say......»»
Researchers use omics technologies to accelerate yam research progress
A research team has summarized current progress on the yam genome, plastome, transcriptome, proteome, and metabolome, highlighting the nutrient-rich and bioactive compound-laden Dioscorea species. This research holds significant value for genetic stu.....»»
The hidden drivers of evolution: Transposable elements in Rosaceae genomes
Transposable elements are mobile DNA sequences that play a crucial role in plant genome architecture and gene regulation. They drive genome size variation and affect gene expression by altering regulatory networks. Despite their significance, the div.....»»
Uncovering Magnetism’s Mysterious Role in the Galaxy
Susan Clark is helping to unravel the mysterious workings of the Milky Way’s magnetic field, a critical missing piece of the galactic puzzle......»»
Telomere-to-telomere genome assembly research opens the door to new crop varieties
Completely new crop varieties which can better withstand drought, salinity and pests are within reach thanks to international genomics research published today in Nature Genetics......»»
Opinion: If we want to settle on other planets, we"ll have to use genome editing to alter human DNA
When considering human settlements on the moon, Mars and further afield, much attention is given to the travel times, food and radiation risk. We'll undoubtedly face a harsh environment in deep space and some thinkers have been pointing to genome edi.....»»
Nanoscopic imaging aids in understanding protein, tissue preservation in ancient bones
A pilot study from North Carolina State University shows that nanoscopic 3D imaging of ancient bone not only provides further insight into the changes soft tissues undergo during fossilization, it also has potential as a fast, practical way to determ.....»»
Study deciphers intricate 3D structure of DNA aptamer for disease theranostics
In a study published in PNAS, a research team has resolved the first high-resolution structure of the sgc8c DNA aptamer that targets protein tyrosine kinase 7 (PTK7), engineered two optimal sgc8c variants for disease theranostics efficiently, and rev.....»»
Genome study informs restoration of American chestnut tree
Native trees adapt to the climate and environmental conditions of their area to survive. Researchers in the College of Natural Resources and Environment in collaboration with the American Chestnut Foundation confirmed this by examining the genome of.....»»
Discovery of a tRNA modification enzyme that also acts on nucleosides
The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis.....»»
Hundreds of new genome sequences fill gaps in the fruit fly tree of life
A multitude of new genomic sequence data fills major gaps in the fruit fly tree of life, Bernard Kim from Stanford University, US, and colleagues report in the open-access journal PLOS Biology, publishing July 18......»»
Ginseng"s full genome sequenced
Ginseng's role in traditional medicine is underscored by its complex genetic structure due to its allotetraploid nature. A recent study delves into this complexity, revealing key evolutionary insights into its subgenomes that govern saponin biosynthe.....»»
Almond genome study paves way for improved breeding strategies
A recent study has unlocked the genetic complexities of almonds, highlighting a significant degree of heterozygosity and the influence of structural variants on gene expression. The research rigorously delineates allele-specific expression patterns,.....»»
Unraveling the DNA mystique of Saposhnikovia divaricata: New horizons in herbal medicine
Scientists have decoded the genetic blueprint of Saposhnikovia divaricata, a traditional medicinal herb. Their research provides a detailed genome sequence, shedding light on the plant's evolutionary adaptations and the genetic foundations of its the.....»»
Study shows ancient viruses fuel modern-day cancers
Peek inside the human genome and, among the 20,000 or so genes that serve as building blocks of life, you'll also find flecks of DNA left behind by viruses that infected primate ancestors tens of millions of years ago......»»
Modular design: New insights into protein factories in human mitochondria
The "power plants" of living cells, the mitochondria, probably evolved through endosymbiosis: A bacterium migrated into a primordial cell and eventually developed into an organelle that provides the cell with energy, among other things. Mitochondria.....»»
Genome recording makes living cells their own historians
Genomes can now be entrusted to store information about a variety of transient biological events inside of living cells, as they happen, like a flight recorder collecting data from an aircraft......»»