Zeroing in on the workings of tumor suppressor protein p53, the "guardian of the genome"
The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and cell death. Now, FMI resea.....»»
We mapped the entire bilby genome—and now we can use poo to save Australia"s "Easter bunny" from extinction
Commonly known as Australia's "Easter bunny" due to its large ears and hopping movement, the greater bilby (Macrotis lagotis) is the last of its kind. Today we published its reference genome—all 3.66 billion pieces of it......»»
Pongamia trees grow where citrus once flourished, offering renewable energy and plant-based protein
An ancient tree from India is now thriving in groves where citrus trees once flourished in Florida, and could help provide the nation with renewable energy......»»
Researchers reveal how plants protect themselves from viral infection by regulating deacetylation
In a paper published in Science Bulletin, a team of Chinese scientists demonstrated that TaSRT2 recognized viral protein P153 and induced wheat resistance to CWMV through inhibition of the TaSRT2-mediated deacetylation of H3K9ac and H3K79ac, which ev.....»»
Researchers pioneer new methods in ultrafast science for sharper molecular movies
Imagine being able to watch the inner workings of a chemical reaction or a material as it changes and reacts to its environment—that's the sort of thing researchers can do with a high-speed "electron camera" called the Megaelectronvolt Ultrafast El.....»»
Pear-derived discovery: A genetic mechanism to fortify crops against drought
A recent study has shed light on a critical genetic mechanism that boosts plants' ability to withstand drought. The research uncovers the role of the transcription factor PbERF3, native to wild pears, which works in concert with the protein PbHsfC1a.....»»
Study finds ways to enhance transcription factor activity
Transcription factors regulate gene expression by binding specific sequences on DNA, which is an essential step to producing messenger RNAs from protein-coding genes. Denes Hnisz's lab, in collaboration with Martin Vingron's lab at the MPIMG, has dis.....»»
A combination of multicore magnetic nanoparticles and chemotherapy drugs achieves greater efficacy against cancer cells
The path to a cure for cancer is not unique, as the disease is an extremely complex process. Multiple factors are involved in the process of effectively eliminating a tumor and therefore, being able to have different strategies against cancer is key.....»»
Average months now feel cold thanks to climate change
People in the UK love discussing the weather. For the first two weeks of June 2024, the cold, dull conditions were all they could talk about. Major news outlets like the BBC, The Guardian, Daily Mail and Daily Telegraph all carried stories on this th.....»»
How (apparently) identical animals can be completely different species
Logically speaking, you would think that animals who appeared to be the same—even if they were found in different parts of the world—would belong to the same species, and that they would share the same genome. However, our recent study has found.....»»
A 4,500-year-old collective tomb in France reveals final stage in formation of the "European genome"
High-resolution analysis of the genomes of individuals buried in a 4,500-year-old collective tomb at Bréviandes-les-Pointes, near the French town of Troyes, has revealed a surprising story with far-reaching implications. As detailed in an article in.....»»
25,000 individuals affected in BBC Pension Scheme data breach
Personal information of current and former BBC employees has been exposed in a data breach that affected the broadcaster’s in-house pension scheme. More than 25,000 individuals have been affected, according to The Guardian. What data was expose.....»»
Researchers uncover protein SRSF1"s uncommon ability to bind and unfold RNA G-quadruplexes
RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence. In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department of Chemistry Professor Jun Zhang, Ph.D., and his te.....»»
New modified CRISPR protein can fit inside virus used for gene therapy
Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells. Hongjian Wang and colleagues a.....»»
Understanding how zwitterionic polymers can lead to safer drugs and disease prevention
Proteins are vital biomolecules responsible for performing various functions in the human body and are thus regarded as the workhorses of a cell. The primary structure of a protein is composed of different amino acids coming together. The structure s.....»»
Researchers apply quantum computing methods to protein structure prediction
Researchers from Cleveland Clinic and IBM have recently published findings in the Journal of Chemical Theory and Computation that could lay the groundwork for applying quantum computing methods to protein structure prediction......»»
Insect frass becomes food for protein-rich microalgae
As the demand for protein-rich food increases with population growth and rising awareness of nutrition and health, traditional animal and plant-based protein sources that require arable land or freshwater put significant pressure on land and resource.....»»
Advancing poplar genomics: Nearly gap-free genome assembly unveils new insights and applications
A research team has successfully assembled a nearly gap-free, telomere-to-telomere (T2T) genome of Populus ussuriensis, filling gaps present in the P. trichocarpa genome. Leveraging long-read sequencing, the team identified and annotated centromere r.....»»
A new Hungarian method may aid protein research
In a paper recently published in Nature Communications, the HUN-REN-ELTE Protein Modeling Research Group (Institute of Chemistry) has laid the foundations for a mathematical method, allowing the computer-assisted comparison of the three-dimensional s.....»»
Scientists elucidate substrate recognition and proton coupling mechanism of transporter protein VMAT2
Vesicular monoamine transporter 2 (VMAT2) is the only transporter protein in the central nervous system that mediates the storage of monoamine neurotransmitters. It plays a critical role in mediating nerve impulse transmission and neuroprotection......»»
Sweet secrets of the bayberry: Genetic insights set to transform fruit quality
The Chinese bayberry, Myrica rubra, is a subtropical fruit highly valued for its distinctive flavor, nutritional benefits, and economic importance. However, previous genome assemblies lacked sequence continuity, hindering comprehensive genetic studie.....»»