Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein
Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are characterized by both sequence and structural similar.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
After wildfires, mudslides come: Fighting the impact of climate change on rural communities
It took more than 25 years for Rhonda MacDonald and her family to transform their 41-hectare property on the Shackan Indian Band Lands, south of Merritt, BC, into a vibrant business and homestead—but a massive 2022 debris flow changed everything in.....»»
The Quantum Mechanics of the Greenhouse Effect
Carbon dioxide’s powerful heat-trapping effect has been traced to a quirk of its quantum structure. The finding may explain climate change better than any computer model......»»
Langbeinites show talents as 3D quantum spin liquids
A 3D quantum spin liquid has been discovered in the vicinity of a member of the langbeinite family. The material's specific crystalline structure and the resulting magnetic interactions induce an unusual behavior that can be traced back to an island.....»»
New "chiral vortex" of light allows chemists to "see" molecules through the mirror
An entirely new structure of light is helping to measure chirality in molecules more accurately and robustly than ever before, in a major potential step for the pharmaceutical industry......»»
Research unravels dual role of membrane protein in rice ethylene signal transduction
A research team, led by Professor Zhang Jinsong from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences, revealed insights into the mechanism by which the membrane protein MHZ3 collaborates with the ethylene.....»»
Vulnerability prioritization is only the beginning
To date, most technology solutions focused on vulnerability management have focused on the prioritization of risks. That usually took the shape of some risk-ranking structure displayed in a table with links out to the CVEs and other advisory or threa.....»»
A small molecular glue that increases P53 level and suppresses tumor growth in vivo
Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, and there has been a lac.....»»
App Store VP departing Apple amid broader restructuring
Apple’s App Store vice president is leaving the company in October, according to a new report from Bloomberg. The structure of the App Store team is also being split into two teams, a change implemented by Phil Schiller in response to the ever-.....»»
Survival tactics: AI-driven insights into chromatin changes for winter dormancy in axillary buds
Evolution has enabled plants to survive under adverse conditions. The winter bud of a plant is a crucial structure that establishes adaptability. Depending on environmental and intrinsic conditions, buds can transition between growth and dormancy. Th.....»»
Cryo-ET study elucidates protein folding helpers in their natural environment
Cryo-electron tomography (cryo-ET), can be used to visualize and analyze cellular structures in their natural environment. Researchers at the MPI of Biochemistry in Martinsried and the University Medical Center Göttingen have now used cryo-ET to stu.....»»
Scientists help turn whisky waste into valuable commodity
A new method to extract valuable bio-based chemicals from whisky distillery waste streams could transform manufacturing and be worth up to £90 million in global chemical manufacturing markets......»»
Comparing methods for extracting edible protein from mealworms
Edible insects are emerging as an alternative protein source that has various benefits compared with conventional animal sources. New research published in the Journal of Food Science compared four different methods for extracting protein from mealwo.....»»
Civilization VII hands-on: This strategy sequel rethinks the long game
Classic turn-based gameplay meets a radical rethink of the overall structure. Enlarge / Firaxis has upped the ante on presentation for the cities. It's still a bit abstract and removed, but they have more vibrancy, detail, and mo.....»»
Researchers teach artificial intelligence about frustration in protein folding
Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial intelligence (AI) technology has made it possible to predict.....»»
Pore structure characteristics found to influence carbon mineralization under conservation tillage
Soil aggregates are the basic units of soil structure and serve as a reservoir for soil carbon, playing a crucial role in the carbon cycle of ecosystems. The pore characteristics of soil aggregates influence the mineralization of soil organic carbon......»»
Neutrons illuminate environmental and biological mysteries
Neutron techniques have long been valued in various scientific fields for their ability to penetrate materials without altering their structure. However, their use in environmental and biological sciences has been limited. Complex systems like soil-w.....»»
This new Snapdragon chip will transform AI on cheaper phones
The Qualcomm Snapdragon 7s Gen 3 puts the emphasis on AI performance and better efficiency, and it will be available in a new phone very soon......»»
Appian helps organizations prepare for current and forthcoming AI regulations
Appian announced the latest version of the Appian Platform, designed to transform how organizations orchestrate enterprise data and automate processes. This release delivers support for more enterprise AI use cases with expanded compliance, offering.....»»
New twist on synthesis technique promises sustainable manufacturing
James Tour's lab at Rice University has developed a new method known as flash-within-flash Joule heating (FWF) that could transform the synthesis of high-quality solid-state materials, offering a cleaner, faster and more sustainable manufacturing pro.....»»