Structural and biochemical basis of methylmalonate semialdehyde dehydrogenase ALDH6A1
ALDH6A1, a member of the ALDH family, plays a crucial role in the catabolic pathways of valine and thymine. Dysregulation of ALDH6A1 expression has been linked to a variety of diseases. Methylmalonate semialdehyde dehydrogenase deficiency (MMSDH defi.....»»
An air-stable single-crystal layered oxide cathode based on multifunctional structural modulation
Sodium-ion batteries (SIBs) are considered a promising energy storage system due to their superior safety properties, low price, and plentiful sodium supplies, while the development of electrode materials plays a critical function in the performance.....»»
Greenhouse gas emissions in Global South countries are linked with International Monetary Fund lending policies
Greenhouse gas emissions significantly increase in countries in the Global South within a few years after initially borrowing from the International Monetary Fund using structural loans, but not when more flexible lending conditions are involved......»»
Transforming wood waste for sustainable manufacturing
Lignin, a complex organic polymer, is one of the main components of wood, providing structural support and rigidity to make trees strong enough to withstand the elements. When transforming wood into paper, lignin is a key ingredient that must be remo.....»»
Genetic basis for the evolution of hair discovered in the clawed frog
The development of hair was of central importance for the evolution of mammals and, thus, also of humans. However, the evolutionary origin of the genetic program of hair was previously unknown. An international research team led by Leopold Eckhart fr.....»»
GM puts 2 newcomers in pivotal roles
General Motors hired Jens Peter Clausen, formerly of Tesla, to lead global manufacturing, while Baris Cetinok, who has worked at Apple and Microsoft, will lead its software and services team on an interim basis......»»
Kurdish uprisings have led to new ways for communities to claim Kurdish identity, study shows
Kurdish uprisings have become a way for people to assert their identity and challenge their historical and structural erasure in modern Iran, a new study shows......»»
New computational strategy boosts the ability of drug designers to target proteins inside the membrane
Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed proteins that can efficiently.....»»
Perturbations in redox status, biochemical indices, genes in the liver following fish exposure to Mancozeb
Due to the increased demand for food for the growing population, pesticides are widely used to control diseases and boost productivity. A study published in the journal Gene Expression was designed to evaluate the toxic effects of the fungicide Manco.....»»
Newly discovered protein prevents DNA triplication
Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent. This means that, millions of times a day, a biochemical wonder takes place in the body: the copying of the DNA molecule. I.....»»
Bio-inspired materials showcase potential for protective equipment and textiles
Bio-inspired materials (BIM) are synthetic materials whose structure and properties are similar to natural materials or living matter. These materials have the potential to advance structural materials, textiles and protective equipment due to their.....»»
Research team reveals cellular and molecular basis of spur development in Impatiens uliginosa
As an important reproductive organ of angiosperms, flowers have a clear purpose and adaptive significance in their various characteristics. As a typical floral evolutionary feature, the floral spur is a tubular structure extending from the petal, whi.....»»
How molecular "handedness" emerged in early biology
Molecules often have a structural asymmetry called chirality, which means they can appear in alternative, mirror-image versions akin to the left and right versions of human hands. One of the great mysteries about the origins of life on Earth is that.....»»
Merons realized in synthetic antiferromagnets
The electronic devices we use on a day-to-day basis are powered by electrical currents. This is the case with our living room lights, washing machines, and televisions, to name but a few examples. Data processing in computers also relies on informati.....»»
Researchers observe the structural heterogeneity of a lipid scramblase
Researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications that TMEM16F, a transmembrane protein that facilitates the passive movement of phospholipids and ions across membranes, explores a larger.....»»
AT&T will pay a miserly $5 per account in outage compensation
AT&T will be providing bill credits to customers over the major February 22 outage, but the $5 credit will be paid on a per-account basis instead of per line.An AT&T logo on a buildingOn February 22, AT&T suffered from an outage that affected its cel.....»»
Study shows how proteins guide electrons to the right place
Cells need energy to function. Researchers at the University of Gothenburg can now explain how energy is guided in the cell by small atomic movements to reach its destination in the protein. Imitating these structural changes of the proteins could le.....»»
A Celebrated Cryptography-Breaking Algorithm Just Got an Upgrade
Two researchers have improved a well-known technique for lattice basis reduction, opening up new avenues for practical experiments in cryptography and mathematics......»»
Combining materials may support unique superconductivity for quantum computing
A new fusion of materials, each with special electrical properties, has all the components required for a unique type of superconductivity that could provide the basis for more robust quantum computing. The new combination of materials, created by a.....»»
Research team identifies new approach to tackling bacterial infections
Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections. The findings are described in Nature Structural & Molecular Biology......»»
Structural isomerization of individual molecules using a scanning tunneling microscope probe
An international research team has succeeded for the first time in controlling the chirality of individual molecules through structural isomerization. The team, led by NIMS, the Osaka University Graduate School of Science and the Kanazawa University.....»»