Structural and biochemical basis of methylmalonate semialdehyde dehydrogenase ALDH6A1
ALDH6A1, a member of the ALDH family, plays a crucial role in the catabolic pathways of valine and thymine. Dysregulation of ALDH6A1 expression has been linked to a variety of diseases. Methylmalonate semialdehyde dehydrogenase deficiency (MMSDH defi.....»»
Two facilities team up for structural biology advances with X-ray free-electron lasers and exascale computing
Plans to unite the capabilities of two cutting-edge technological facilities promise to usher in a new era of dynamic structural biology. Through DOE's Integrated Research Infrastructure, or IRI, initiative, the facilities will complement each other'.....»»
The surprise is not that Boeing lost commercial crew but that it finished at all
"The structural inefficiency was a huge deal." Enlarge / Boeing's Starliner spacecraft is lifted to be placed atop an Atlas V rocket for its first crewed launch. (credit: United Launch Alliance) NASA's senior leaders in.....»»
"Degree of Kevin Bacon" gene provides possible basis for central players in group connectedness
A team of biologists and geneticists at the University of Toronto at Mississauga has found a possible genetic basis for a central player in group connectedness. In their study, published in the journal Nature Communications, the group conducted genet.....»»
Chemists use new approach in the synthesis of complex natural substances
They are found as fragrances in cosmetics or as flavorings in food, and form the basis of new medications: Terpenes are natural substances that occur in plants, insects and sea sponges. They are difficult to produce synthetically. However, chemists a.....»»
Inexpensive spring truffles or exquisite Piedmont truffles? New analytical method can detect food fraud
Some truffles are particularly expensive and therefore often the target of food fraud. For example, high-priced Piedmont truffles (Tuber magnatum) are often difficult to distinguish from the cheaper spring truffles (T. borchii) on the basis of their.....»»
Saturday Citations: Irrationality modeled; genetic basis for PTSD; Tasmanian devils still endangered
Hello, stakeholders. (This is the nongendered term of address I've been workshopping because I see "folks" in too many social media posts.) Researchers this week reported on an AI model that attempts to emulate human irrationality in decision-making,.....»»
Pixel 9 Release Date: What to Expect
With Pixel 9 rumors popping up on a regular basis, we’ve received questions about the release date. If you’re interested in Google’s Pixel 9, allow us to help set expectations regarding its release date. In recent months, we’v.....»»
Atom-by-atom: Imaging structural transformations in 2D materials
Silicon-based electronics are approaching their physical limitations and new materials are needed to keep up with current technological demands. Two-dimensional (2D) materials have a rich array of properties, including superconductivity and magnetism.....»»
Advanced nuclear magnetic resonance technique reveals precise structural, dynamical details in zeolites
Zeolites are widely used in many industries, yet their intrinsic catalytic nature is not completely understood, due to the complexity of the hydroxyl-aluminum moieties......»»
Illuminating the path to hearing recovery: Structural insights into a receptor protein"s role in auditory function
Researchers have worked to uncover the mysteries surrounding a specific receptor protein associated with hearing. Professor Yunje Cho's research team from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH, Republ.....»»
Designing a cost-effective X-ray free electron lasers facility
Many advances in structural science since the 1970s were made by probing materials with synchrotron radiation: that is, high energy X-rays generated through accelerating high-energy electrons. The latest generation of such sources, X-ray free electro.....»»
18 essential movies about the fight for women"s equality
From "On the Basis of Sex" to "Suffragette," pay your respects to everyday activists, revolutionaries, and rebels who paved the way for women's equality. The modern feminist movement isn’t an ambiguous, shapeless mist that has acted of it.....»»
Research unveils biochemical defenses against chemical warfare
In the clandestine world of biochemical warfare, researchers are continuously seeking innovative strategies to counteract lethal agents. Researchers led by Jin Kim Montclare, Professor in the Department of Chemical and Biomolecular Engineering, have.....»»
Team presents new path to long-term data storage based on atomic-scale defects
With the development of the internet, social media and cloud computing, the amount of data created worldwide on a daily basis is sky-rocketing. This calls for new technologies that could provide higher storage densities combined with secure long-term.....»»
How plants heal wounds: Mechanical forces guide direction of cell division
Plants are made up of very rigid cells. Much like bricks in a wall, this feature gives them the structural support to maintain their shape and to stand upright against gravity. However, just like any living organism, plants can be injured, for instan.....»»
Structural and biochemical basis of methylmalonate semialdehyde dehydrogenase ALDH6A1
ALDH6A1, a member of the ALDH family, plays a crucial role in the catabolic pathways of valine and thymine. Dysregulation of ALDH6A1 expression has been linked to a variety of diseases. Methylmalonate semialdehyde dehydrogenase deficiency (MMSDH defi.....»»
Researchers reveal impact of brassinosteroid and sugar signal on wheat grain size regulation
Grain size plays a central role in determining wheat yield, and precise regulation of grain development has emerged as a key strategy for increasing yields in several staple crops such as rice and maize. However, the genetic basis and potential molec.....»»
Core-shell structural units show outstanding toughening effect for ceramics
Toughening has always been an important research direction of structure ceramics. The addition of secondary phases to the ceramic matrix to prepare composite ceramics is an effective toughening pathway in the field of structure ceramics......»»
A dynamically stable self-healable wire based on mechanical–electrical coupling
Highly flexible and conductive wires play a crucial role in integration and application of wearable devices. However, the frequent stress and deformation in practical use are prone to cause structural damage to these wires, leading to failure of the.....»»
Decoding the plant world"s complex biochemical communication networks
A Purdue University-led research team has begun translating the complex molecular language of petunias. Their grammar and vocabulary are well hidden, however, within the countless proteins and other compounds that fill floral cells......»»