Zeroing in on the workings of tumor suppressor protein p53, the "guardian of the genome"
The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and cell death. Now, FMI resea.....»»
Researchers identify body"s "quality control" regulator for protein folding, could lead to targeted treatments
Anyone who's tried to neatly gather a fitted sheet can tell you: folding is hard. Get it wrong with your laundry and the result can be a crumpled, wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins with an origami-.....»»
Developing a simple, cost-effective method to identify the targets of a crucial protein-modifying enzyme
Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at EMBL Grenoble have developed a new method to study a.....»»
The molecular shield: How tea plants combat drought through protein phosphorylation
Drought stress poses a significant challenge to agriculture, causing substantial yield losses in many crops. Tea plants, known for their rich flavonoid content which enhances both quality and health benefits, are particularly affected. Under drought.....»»
Researchers develop AI model that predicts the accuracy of protein–DNA binding
A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance that promises to reduce the t.....»»
Bacteria encode hidden genes outside their genome; do we?
Since the genetic code was first deciphered in the 1960s, our genes have seemed like an open book. By reading and decoding our chromosomes as linear strings of letters, like sentences in a novel, we can identify the genes in our genome and learn why.....»»
Editing for resilience: CRISPR/Cas9 boosts potato stress resistance
Scientists have made a significant breakthrough in agricultural biotechnology by using CRISPR/Cas9 to edit the potato genome, resulting in plants with increased resistance to both biotic and abiotic stresses. This innovation could lead to a new era o.....»»
Largest protein yet discovered builds algal toxins
While seeking to unravel how marine algae create their chemically complex toxins, scientists at UC San Diego's Scripps Institution of Oceanography have discovered the largest protein yet identified in biology......»»
Heat stress survival: Unraveling the HsfA2-ACTIN dynamics in lily varieties
A research team has identified that the heat stress transcription factor HsfA2 and actin-interacting protein (AIP) LACTIN interact at the protein level in Lilium longiflorum "White Heaven," mediating gene expression and protecting cells from heat str.....»»
A review of the Epichloë festucae antifungal protein Efe-AfpA
A research team has reviewed the mechanisms behind endophyte-mediated disease resistance in strong creeping red fescue (Festuca rubra subsp. rubra) and identified the antifungal protein Efe-AfpA produced by Epichloë festucae as a key factor against.....»»
Predicting metabolic potential in bacteria from limited genome data
How bacteria eat food, and what kinds of products they can make from that food, is dictated by the metabolic network of enzyme patterns encoded in their genomes. Using computational methods to learn these patterns across a large number of known bacte.....»»
How ribosomes in our cells enable protein folding
Scientists at UCL have discovered a novel role played by ribosomes during the folding of new proteins in cells, described in their paper in Nature......»»
Ancient viral elements in RNA kickstart bone repair
Around half of the human genome is composed of DNA fragments originating from ancient viruses. These "transposable elements" (TEs) are now known to play various roles in modulating gene expression and disease development. Now, an international team l.....»»
Scientists take atomic look at a protein complex that grants access to our DNA
To transcribe the information contained in our genes or to repair the dozens of breaks that occur daily in our DNA, our enzymes must be able to directly access the DNA to perform their functions. However, in the cell nucleus, this access is limited b.....»»
The effects of whole genome duplication on the plant metabolome
Whole genome duplication (WGD) is a common mutation in plants with profound evolutionary potential. While it is well-known that an increase in genetic material can lead to larger cell sizes, the impact of gene dosage multiplication on the metabolome.....»»
Scientists "cautiously optimistic" about AI"s role in drug discovery
The human body contains at least 20,000 different proteins, often called the "workhorses of the cell" because of their role in keeping cells healthy. Each protein consists of a unique string of amino acids that affects its shape and function—or dys.....»»
Researchers elucidate mechanisms behind protein selectivity in adenosine receptor
In a new study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate th.....»»
Climate change may lead to shifts in vital Pacific Arctic fisheries
Marine fisheries are an essential source of protein for a large part of the world's population, as well as supporting around 390 million livelihoods and an industry worth approximately US$ 141 billion, according to the UN FAO. Yet, climate change pre.....»»
How duplicated genomes helped grasses diversify and thrive
Grasses cover about 40% of the Earth's land surface, thriving in a multitude of environments. The evolutionary success of this plant family, which includes rice, maize, wheat and bamboo, likely results from a history of whole-genome duplications, acc.....»»
ACE-ing protein detection in single cells
Since the 1950s, researchers have used a famous method invented by Wallace Coulter known as "flow cytometry" to characterize different types of immune cells in research studies and in blood samples from human individuals. This has enabled a much deep.....»»
Precise genetics: New CRISPR method enables efficient DNA modification
With the revolutionary CRISPR/Cas technology, the DNA of living organisms can be precisely altered. Using a guide RNA that recognizes a specific DNA sequence, Cas9 protein is recruited to that sequence and cuts the DNA. This targeted cut allows the D.....»»