Parasite engineered to deliver therapy proteins to nerve cells
An international team of neurobiologists has developed a way to use a parasite to deliver protein therapies through the blood–brain barrier to treat nerve cell disorders. In their study published in Nature Microbiology, the group engineered the par.....»»
Discovery of enzyme pathway may lead to lifesaving leishmaniasis treatments
A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more effective drugs for human leishmaniasis, a parasitic disease that afflicts about 1 million people and kills about 30,000 peopl.....»»
Genetically encoded biosensors measure living cells" charge in real time
Biological cells have many vital functions in the organism. For example, they produce proteins, carbohydrates and fats. But they are also responsible for detoxifying harmful molecules and transmitting signals and immune defense steps. A so-called red.....»»
Scientists steer the development of stem cells to regenerate and repair organs
Investigators from Cedars-Sinai and the University of California, San Francisco (UCSF) have identified a new way to deliver instructions that tell stem cells to grow into specific bodily structures, a critical step in eventually regenerating and repa.....»»
Programming cells: New RNA tool enhances precision in synthetic genetic circuits
Researchers have successfully developed a modular synthetic translational coupling element (SynTCE), significantly enhancing the precision and integration density of genetic circuits in synthetic biology. Their study was recently published in the jou.....»»
ESA and NASA satellites deliver first joint picture of Greenland Ice Sheet melting
Academics from Northumbria University are part of an international research team which has used data from satellites to track changes in the thickness of the Greenland Ice Sheet......»»
Molecular tool demonstrates how bad eggs are identified for destruction by reproductive system
The biological factory that produces reproductive cells has a robust quality control system to identify and eliminate eggs with chromosomal abnormalities. For years, cell biologists have sought to uncover the mechanisms behind this system, relying on.....»»
Researchers highlight role "workhorse protein" plays in keeping nervous system running smoothly
A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are vital in ensuring that neurons can transmit signals to one another. When this neurotransmission breaks down, devastating dise.....»»
Nanoliposomes pave way for treatment of rare genetic disorder
An international research team has developed a new therapy based on nanotechnology called nanoGLA for the treatment of Fabry disease. The new therapeutic solution has shown remarkable efficacy in preclinical studies. The study was published this Dece.....»»
Study reveals how transcription factors navigate DNA architecture to shape cellular identity
A new study led by Prof. Yosef Buganim from the Hebrew University of Jerusalem and Dr. Abdenour Soufi from the University of Edinburgh reveals how transcription factors (TFs)—key proteins that regulate gene activity—navigate DNA and chromatin str.....»»
Molecular gardening: New enzymes discovered for protein modification pruning
Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases, including cancer and neurodegenerative disorders......»»
Rocket-inspired reaction yields carbon with record surface area
Using a chemical reaction inspired by rocket fuel ignition, Cornell researchers have engineered a nanoporous carbon with the highest surface area ever reported, a breakthrough that is already proving beneficial for carbon-dioxide capture and energy s.....»»
New method maps hundreds of proteins in cell nuclei simultaneously
Caltech researchers have developed a new method to map the positions of hundreds of DNA-associated proteins within cell nuclei all at the same time. The method, called ChIP–DIP (Chromatin ImmunoPrecipitation Done In Parallel), is a versatile tool f.....»»
Building a backbone: Scientists recreate the body"s "GPS system" in the lab
Scientists at the Francis Crick Institute have generated human stem cell models which, for the first time, contain notochord—a tissue in the developing embryo that acts like a navigation system, directing cells where to build the spine and nervous.....»»
Vanir: Open-source security patch validation for Android
Google’s open-source tool Vanir enables Android developers to quickly scan custom platform code for missing or applicable security patches. By automating patch validation, Vanir helps OEMs deliver critical security updates faster, enhancing the.....»»
Brain cells mature faster in space but stay healthy: ISS study
Microgravity is known to alter the muscles, bones, the immune system and cognition, but little is known about its specific impact on the brain. To discover how brain cells respond to microgravity, Scripps Research scientists, in collaboration with th.....»»
Unlocking the brain: Peptide-guided nanoparticles deliver mRNA to neurons
Penn Engineers have modified lipid nanoparticles (LNPs)—the revolutionary technology behind the COVID-19 mRNA vaccines—to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthroug.....»»
Yeast cell wall proteins offer possible alternative to emulsifiers derived from milk
Mention emulsifiers and many people might be unaware of what they are used for, but they are present in many daily products, from food to cosmetics. They keep substances that don't usually mix, like water and oil, from separating and are either synth.....»»
Novel platinum complex shows strong antiproliferative effects with low toxicity in preclinical prostrate cancer models
Prostate cancer remains a global health challenge, ranking as the second most commonly diagnosed cancer among men. Although treatments like androgen deprivation therapy have been effective for early-stage prostate cancer, advanced stages, such as cas.....»»
MagSafe Monday: Want a simple MagSafe dock? Check out the GOWATT MagSafe dock
If you’re in the market for a sleek, no-fuss MagSafe dock, the might just be your next favorite accessory. With its elegant aluminum build, it’s designed to deliver functionality and style that seamlessly works with your iPhone. more….....»»
Risk Aperture AI360 manages AI-specific vulnerabilities and threats
Risk Aperture launched AI360, a solution designed to address the growing cybersecurity risks posed by artificial intelligence (AI). AI360 leverages proprietary algorithms, predictive analytics, and machine learning to deliver actionable insights, he.....»»