Using starch as a novel drug transporter
A special type of starch could soon be used as an excipient in medicine to improve the treatment of patients. A research team from Martin Luther University Halle-Wittenberg (MLU) has discovered that it makes a suitable drug release system and has adv.....»»
New weight-loss and diabetes drugs linked to lower risk of 10 cancers
For diabetes patients, GLP-1 drugs linked to lower cancer risks compared to insulin. Enlarge / Ozempic is a GLP-1 drug for adults with type 2 diabetes. (credit: Getty | Steve Christo) For patients with Type 2 diabetes, t.....»»
First set of rational design principles for chaotropic membrane transporters
The challenge of internalizing impermeable molecules into cells persists in drug development, particularly concerning water-soluble bioactive compounds that cannot diffuse across the cell membrane. To overcome this problem, various artificial transpo.....»»
AI able to identify drug-resistant typhoid-like infection from microscopy images in matter of hours
Artificial intelligence (AI) could be used to identify drug resistant infections, significantly reducing the time it takes for a correct diagnosis, Cambridge researchers have shown. The team determined that an algorithm could be trained to identify d.....»»
Graph learning modules enhance drug-target interaction predictions
The identification of drug-target Interactions (DTIs) represents a pivotal link in the process of drug development and design. It plays a crucial role in narrowing the screening range of candidate drug molecules, thereby facilitating the reuse of dru.....»»
New mRNA technology turns cells into long-lasting drug factories
A team of researchers has established a ribonucleic acid (RNA)-based method that drives cells in the body to produce therapeutic proteins and secrete them into the bloodstream. The approach could potentially extend the lifespan of drugs in the body,.....»»
A new way to see viruses in action: Super-resolution microscopy provides a nano-scale look
A new, nano-scale look at how the SARS-CoV-2 virus replicates in cells may offer greater precision in drug development, a Stanford University team reports in Nature Communications. Using advanced microscopy techniques, the researchers produced what m.....»»
Scientists elucidate substrate recognition and proton coupling mechanism of transporter protein VMAT2
Vesicular monoamine transporter 2 (VMAT2) is the only transporter protein in the central nervous system that mediates the storage of monoamine neurotransmitters. It plays a critical role in mediating nerve impulse transmission and neuroprotection......»»
Drug trafficker wouldn’t get out of car, hinted something was inside, GA deputies say
Drug trafficker wouldn’t get out of car, hinted something was inside, GA deputies say.....»»
A synthetic drug ravages youth in Sierra Leone. There"s little help, and some people are chained
A synthetic drug ravages youth in Sierra Leone. There"s little help, and some people are chained.....»»
Unveiling a novel AAK1 inhibitor: How chemical proteomics unlock therapeutic potential
Enhancing drug development for life-threatening diseases like cancer hinges on a deep understanding of protein kinases, making it a focal point for researchers. These enzymes, encoded by more than 500 human genes, serve as critical players in cellula.....»»
The next food marketing blitz is aimed at people on new weight-loss drugs
Taking a weight-loss drug? Food makers have just the new food for you. Enlarge (credit: Getty | Jeffrey Greenberg) As new diabetes and weight-loss drugs help patients curb appetites and shed pounds, food manufacturers ar.....»»
How yeasts manage to compensate for the genetic imbalance of extra chromosomes
Having extra chromosomes is typically an issue for an organism and can disrupt development or cause disease. But some cells benefit instead. For example, cancer cells or pathogenic yeasts can use extra chromosomes to escape treatment and become drug-.....»»
Study decodes dimerization and antidepressant recognition at noradrenaline transporter
The noradrenaline transporter, also known as the norepinephrine transporter (NET), is a member of the monoamine transporters (MATs) family, which also includes serotonin transporter (SERT) and dopamine transporter (DAT). These transporters collective.....»»
Scientists" new drug-delivery technology is possible breakthrough for multi-strain vaccines
A new way to deliver drugs using a common protein could be used to develop mosaic vaccines, which are vaccines effective against multiple strains of a virus like COVID-19, among other medicines in a global first......»»
Cancer drug pollution is a growing global concern
As incidence of cancer increases globally, the use of cancer drugs is also growing at a rate of approximately 10 percent per year in developed countries......»»
Physicists propose path to faster, more flexible robots
In a May 15 paper released in the journal Physical Review Letters, Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug d.....»»
Protein prediction technology yields accurate results to efficiently find the best drug candidate for many conditions
Artificial intelligence (AI) has numerous applications in health care, from analyzing medical imaging to optimizing the execution of clinical trials, and even facilitating drug discovery......»»
Wegovy Can Keep Weight Off for at Least 4 Years, Research Shows
Users receiving weekly injections saw their weight fall, plateau, and stabilize over the course of a four-year trial—but it’s still unclear how long these effects last after stopping taking the drug......»»
Research identifies mechanism behind drug resistance in malaria parasite
Collaborating researchers have discovered a link between malaria parasites' ability to develop resistance to antimalarial drugs—specifically artemisinin (ART)—through a cellular process called transfer ribonucleic acid (tRNA) modification. tRNA m.....»»
Heating proteins to body temperature reveals new drug targets
Some proteins shift their shape when exposed to different temperatures, revealing previously unknown binding sites for medications, new research has found......»»