Using starch as a novel drug transporter
A special type of starch could soon be used as an excipient in medicine to improve the treatment of patients. A research team from Martin Luther University Halle-Wittenberg (MLU) has discovered that it makes a suitable drug release system and has adv.....»»
Scientists reveal transport mechanism of norepinephrine transporter and binding mode of small molecule and peptide drugs
Noradrenaline (NA) is an important monoamine neurotransmitter in the nervous system. The noradrenaline transporter (NET) located on the presynaptic membrane can transport NA into presynaptic neurons......»»
Electrical impedance tomography plus extracellular voltage activation technique simplifies drug screening
When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical. Blocking hERG channels can disrupt a normal hear.....»»
"Russian doll" packaging could boost drug delivery
New technology, which is in the early stages of development, has the potential to significantly enhance the effectiveness and reduce the side effects of drugs and vaccines......»»
New and improved drug-delivery molecules for skeletal muscle
Researchers from Tokyo Metropolitan University have created a new drug-delivery molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RN.....»»
Research team develops new antimalarial agent for combating drug-resistant parasites
Malaria remains a serious health issue globally, especially in Africa. The disease is caused by protozoan parasites in the Plasmodium genus. In 2021, there were 247 million cases of malaria and 619,000 deaths reported worldwide......»»
Counter-drug strategies in Central America are worsening deforestation, threatening many species of birds
Activities associated with cocaine trafficking threaten two-thirds of the most important landscapes in Central America for 196 forest bird species, including 67 migratory species. This is the key takeaway from a study that colleagues and I published.....»»
Illegal drug found in Diamond Shruumz candies linked to severe illnesses
New testing finds psilocin, related to psilocybin, in gummies purchased in 2023. Enlarge (credit: Diamond Shruumz) Newly released testing data of Diamond Shruumz-brand gummies purchased in 2023 identified the presence of.....»»
De-risking drug discovery with predictive AI
Developing a new drug can take years of research and cost millions of dollars. Still, more than 90% of drug candidates fail in clinical trials, with even more that never make it to the clinical stage. Many drugs fail because they simply aren't safe......»»
Dynamic view of opioid receptor could refine pain relief
Effective pain relief without the debilitating side effects of traditional opioids is closer to becoming a reality thanks to a study by an all-RIKEN team into the structure and dynamics of a drug-bound opioid receptor......»»
Engineered nanovesicles from activated neutrophils show promise in treating infected wounds
Infectious wounds represent a critical challenge in health care, especially for diabetic patients grappling with ineffective antibiotics and escalating drug resistance. Conventional therapies often inadequately address deep tissue infections, highlig.....»»
The evolving single-cell and spatial technology landscape
The scTrends consortium has published its first report shedding light on the current state of the commercial single-cell and spatial genomics industry and its potential impact on drug discovery and patient care......»»
Chemists develop modular approach for creating important class of pharmaceutical compounds
Chemists at the National University of Singapore (NUS) have developed a modular approach to create 1,2-arylheteroaryl ethanes, a class of compounds important for drug discovery and pharmaceutical development, using fundamental feedstock chemicals suc.....»»
Rite Aid says breach exposes sensitive details of 2.2 million customers
Stolen data includes customer names, addresses, birth dates, and driver's license numbers. Enlarge / Rite Aid logo displayed at one of its stores. (credit: Getty Images) Rite Aid, the third biggest US drug store chain, s.....»»
Lab develops smallest free-floating bubbles for medical imaging
Bioengineering researchers at Rice University have developed ultrasmall, stable gas-filled protein nanostructures that could revolutionize ultrasound imaging and drug delivery......»»
New class of organic nanoparticles shows promise for diverse applications
Nanoparticles have a wide variety of applications, from drug delivery to electronics to air purification. Their small size and tunable properties make them particularly valuable for technological advancements and scientific research. When polymers ma.....»»
Research team develops light-activated compounds to treat neuropathic pain
Light can be used to activate drugs in specific parts of the body through photopharmacology. This innovative approach involves modifying the chemical structure of a drug by adding a light-activated molecular switch, such as azobenzene. This allows th.....»»
A comprehensive derivative synthesis method for development of new antimicrobial drugs
Efforts to combat the increasing threat of drug-resistant bacteria are being assisted by a new approach for streamlining the search for antimicrobial drug candidates, pioneered by researchers at Hokkaido University, led by Assistant Professor Kazuki.....»»
What Makes a Psychedelic Experience? Not Always a Drug, It Turns Out
A Stanford anesthesiologist deconstructs the component parts of what it means to undergo a psychedelic trip.....»»
We’re Not Asking the Right Question to Solve the Overdose Crisis
Drug policy continues to fixate on symptoms rather than the actual disease.....»»
Drug middlemen inflate US prices, squeeze out competition, FTC says
Pharmacy benefit managers (PBMs) are key part of US's high drug costs, report finds. Enlarge / Lina Khan, chair of the Federal Trade Commission (FTC), testifies before the House Appropriations Subcommittee at the Rayburn House O.....»»