Nucleoside analogs for messenger RNA metabolic labeling and sequencing
High-throughput RNA-sequencing (RNA-seq) is widely used to profile global cellular gene expression and gain insights into cellular biological processes; however, effectively tracking dynamic changes in cellular mRNA expression remains a challenge. Be.....»»
Parents Labeling a Kid’s Friend a Bad Influence Can Backfire
Is your kid in trouble? Blaming their friends is ill advised.....»»
Improved lipid-polymer nanoparticle could advance inhalable mRNA medications and vaccines
Most people don't enjoy getting shots for treatments or vaccines. So, researchers are working to create more medicines, such as those made from messenger RNA (mRNA), that can be sprayed and inhaled......»»
Young coral use metabolic tricks to resist bleaching, research reveals
Coral larvae reduce their metabolism and increase nitrogen uptake to resist bleaching at high temperatures, according to a study published November 12 in the open-access journal PLOS Biology by Ariana S. Huffmyer of the University of Washington, US,.....»»
Mitochondrial study offers new insights into how our cells process RNA for energy production
Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have made a major discovery in how human cells produce energy. Their study, published in The EMBO Journal, reveals the detailed mechanisms of how mitochondria process.....»»
Grocery stores are more reliable than sushi restaurants in labeling salmon properly, Seattle study finds
In a study of salmon samples from Seattle, Washington, grocery stores and sushi restaurants, DNA analysis revealed that 18% were mislabeled. Tracie Delgado and colleagues at Seattle Pacific University, WA, U.S., present these findings in the open-acc.....»»
Testing thousands of RNA enzymes helps find first "twister ribozyme" in mammals
The "RNA world" hypothesis proposes that the earliest life on Earth may have been based on RNA—a single-stranded molecule similar in many ways to DNA—like some modern viruses. This is because, like DNA, RNA can carry genetic information, but, lik.....»»
Genome sequencing of all four Macadamia species unlocks new potential for crop improvement
A research team has successfully sequenced and assembled the genomes of all four Macadamia species, marking a significant advance in crop improvement efforts for this commercially valuable nut. The findings reveal key genetic traits that could enhanc.....»»
Study reveals effect of slope position on nonstructural carbohydrates in biological soil crusts
Nonstructural carbohydrates (NSCs) provide energy for metabolic processes in plants and play a key role in plant growth, defense and osmoregulation. However, the regulation of NSC in biological soil crusts across different slope positions remains unc.....»»
Sequencing one of the world"s oldest trees to learn how mutations occur in clonally reproducing organisms
A team of biologists, environmental scientists and geneticists affiliated with multiple institutions across the U.S. has learned more about how mutations occur in clonally reproducing organisms by sequencing one of the oldest trees in the world. The.....»»
RNA sequencing approach offers real-time and programmable transcriptome sequencing
The high complexity and diversity of the eukaryotic transcriptome poses significant challenges for the efficient detection of specific transcripts. Conventional targeted RNA-seq methods often require labor-intensive pre-sequencing enrichment steps, w.....»»
A global imbalance in reference genomes: Research highlights need for sequencing resources in biodiversity-rich areas
Montana State University and Universidad de los Andes researchers have detected a significant imbalance in the distribution of tetrapod reference genomes. They find a disproportionate concentration of studies in high-latitude regions compared to wher.....»»
Advancing drug delivery: New framework links lipid nanoparticle structure to immune response
A new framework bridges a gap in understanding RNA therapeutics by linking the structure of lipid nanoparticles to immune response. It can help scientists and engineers expand the use of RNA medicines beyond vaccines to other therapeutic applications.....»»
New technology illustrates bacterial "hibernation states"
Like hibernating bears, certain bacterial cells have the ability to shift into a "low-power" metabolic state in which they can stably survive without growing. This state is often seen in the context of antibiotic-resistant infections as bacteria form.....»»
DNA-binding C2H2 zinc finger proteins also regulate RNA processing, researchers discover
Researchers at the University of Toronto have shown that an important class of DNA-binding factors can also bind to RNA, regulating gene expression through various mechanisms. The study significantly expands our understanding of these proteins' funct.....»»
Researchers develop database for catalytic bioparts with experimental evidence
Catalytic bioparts are fundamental to the design, construction and optimization of biological systems for specific metabolic pathways. A research team from the Chinese Academy of Sciences (CAS) has recently developed a Registry and Database of Biopar.....»»
Genome sequencing could unlock answers to yellow jacket behavior
The most recognizable yellow jacket at Georgia Tech is made of fabric and foam, but Professor Mike Goodisman and a team of researchers revealed a far more complex cellular structure by successfully sequencing the genome of two local species of yellow.....»»
First mRNA stabilizing substance could aid in development of innovative mRNA therapeutics
Messenger RNA–based therapeutics and vaccines are the new hope in the fight against incurable diseases. A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the destruction of disease-causing mRNA. Achieving the.....»»
Targeting bacteria: Auxiliary metabolic genes expand understanding of phages and their reprogramming strategy
Viruses that infect bacteria—known as bacteriophages—could be used in a targeted manner to combat bacterial diseases. They also play an important ecological role in global biogeochemical cycles. Recent research by researchers at the University of.....»»
Expansion in situ genome sequencing innovation makes hidden DNA-protein interactions visible
Harvard scientists have unveiled a new technique called expansion in situ genome sequencing (ExIGS) that combines existing in situ genome sequencing (IGS) with expansion microscopy (ExM). The innovation allowed researchers to link nucleus abnormaliti.....»»
Cells From Different Species Can Exchange ‘Text Messages’ Using RNA
Long known as a messenger within cells, RNA is increasingly seen as life’s molecular communication system—even between organisms widely separated by evolution......»»