New signaling pathway decoded in the decomposition of damaged lysosomes
Lysosomes are surrounded by a lipid bilayer that separates the acidic environment and the digestive enzymes of the organelle from the cytoplasm. Damage to this layer—lysosomal membrane permeabilization, or LMP for short—can trigger inflammation a.....»»
Scientists identify novel lysosome fission factor
Lysosomes are centers for degradation, recycling, and signaling of cellular materials that are crucial for maintaining cellular homeostasis, development, and aging. To meet various physiological demands, lysosomes continuously remodel their shape and.....»»
Researchers discover new microRNA-regulated pathway to boost iPS cell-derived platelet production
A team of researchers led by Professor Koji Eto (Department of Clinical Application) recently discovered the importance of a microRNA-based regulatory mechanism for enhancing the quality and quantity of platelets generated by iPS cell-derived megakar.....»»
Technician damaged vehicle learning to drive a manual transmission, lawsuit alleges
Two technicians at a Milford, Conn., dealership allegedly damaged a service customer's "dream car" during a joyride where the older one wanted to teach the younger one how to drive a manual transmission vehicle......»»
Core-shell structural units show outstanding toughening effect for ceramics
Toughening has always been an important research direction of structure ceramics. The addition of secondary phases to the ceramic matrix to prepare composite ceramics is an effective toughening pathway in the field of structure ceramics......»»
Hyundai, Kia to recall 147,100 U.S. vehicles over damaged charging unit, NHTSA says
Hyundai will recall 98,878 vehicles, affecting certain Ioniq and Genesis models, while Kia will recall 48,232 vehicles impacting certain EV6 models......»»
Research team establishes synthetic dimension dynamics to manipulate light
In the realm of physics, synthetic dimensions (SDs) have emerged as one of the frontiers of active research, offering a pathway to explore phenomena in higher-dimensional spaces, beyond our conventional 3D geometrical space. The concept has garnered.....»»
Electronic perturbation-promoted interfacial pathway for facile C–H dissociation
Pt-based catalysts have been extensively employed in catalytic propane dehydrogenation (PDH) processes, playing a crucial role in propylene production. However, monometallic Pt catalysts often exhibit inferior propylene selectivity due to the hydroge.....»»
Pesticide-free as a new pathway for agriculture
A new approach is gaining momentum in European agriculture: a "third way" that lies between conventional production and organic farming systems. Here farmers must forego synthetic pesticides only—which is simpler to implement than a switch to organ.....»»
How the Tudors dealt with food waste
More than 10 million tons of food is wasted in the UK each year. Leftovers perish in their plastic Tupperware tombs, supermarket bins heave with damaged but perfectly edible produce, and fields are littered with spoiled harvests. Preventing good food.....»»
Cut submarine cables cause web outages across Africa; 6 countries still affected
Parts of Africa were already seeing web disruptions from damaged Red Sea cables. Enlarge / View of Le Plateau and Ebrie Lagoon from the top of the Cathedrale St-Paul in Côte d'Ivoire (Ivory Coast), one of the affected countries.....»»
Research uncovers specific protein interactions needed for cells to break down and remove damaged mitochondria
Autophagy is a process used by cells as a recycling system to transport and break down organelles and other cytosolic components, which become enveloped in a membrane called the autophagosome. When this involves the removal of damaged mitochondria, i.....»»
Increasing soil organic matter to improve soil health, carbon storage
Soil organic matter (SOM) is crucial to soil health and carbon storage in agriculture. Adding crop residues to the soil increases SOM, but can also accelerate its decomposition, known as the priming effect. The temperature sensitivity (Q10) of SOM de.....»»
Advancing tissue engineering with shape memory hydrogels
One of the primary goals in the field of tissue engineering and regenerative medicine is the development of artificial scaffolds that can serve as substitutes for damaged tissue. These materials must ideally resemble natural tissue and must have the.....»»
Tsetse fly fertility damaged after just one heat wave, study finds
The fertility of both female and male tsetse flies is affected by a single burst of hot weather, researchers at the University of Bristol and Stellenbosch University in South Africa have found......»»
Scientists find that micronuclei are not the primary trigger of the cGAS/STING pathway
Cells possess an innate immune system that defends against invasive pathogens such as bacteria and viruses. Previous studies have mapped out the cytoplasmic cGAS-STING pathway in the cytoplasm, known for responding to foreign nucleic acids, such as d.....»»
Kansas, Nebraska dealership groups granted trials in hail damage dispute
Two Great Plains dealership groups have won the right to trials on assertions their insurers wrongfully refused to fully reimburse them for repairing hail-damaged vehicles......»»
Good news for coral reef restoration efforts: Study finds "full recovery" of reef growth within four years
While the majority of the world's reefs are now under threat or even damaged potentially beyond repair, a new study reported in the journal Current Biology on March 8 offers some encouraging news: efforts to restore coral reefs not only increase cora.....»»
Enhancing apple adventitious shoot regeneration: The role of MdAIL5 in hormonal signaling and gene activation
Plants exhibit a remarkable capacity for self-repair and regeneration, a process crucial for adapting to environmental changes and underpinned by cellular totipotency or pluripotency. Apple is one of the model plants for the study of perennial woody.....»»
How having self-control leads to power
Out-of-control behavior by CEOs and other powerful people constantly makes headlines—so much so that some might consider impulsivity a pathway to power. New research from the UC San Diego Rady School of Management and Texas A&M University finds tha.....»»
Exploring the landscape of shadow education
The diverse forms of private tutoring range from one-to-one sessions to large lecture halls with video screens. Parents and students seek this supplement to gain a competitive edge in countries where academic achievement is seen as a pathway to futur.....»»