New ligand-guided technique enhances drug development
Achieving a level of precision to create complex medicines and materials with extreme accuracy is a longstanding goal of scientists and pharmaceutical companies. If achieved, that precision could lead to the development of more effective drug treatme.....»»
Modified ribosomes could be a possible mechanism of antibiotic resistance
Bacteria modify their ribosomes when exposed to widely used antibiotics, according to research published in Nature Communications. The subtle changes might be enough to alter the binding site of drug targets and constitute a possible new mechanism of.....»»
Parasite genome analysis provides a new approach to predicting malaria drug resistance
Researchers at University of California San Diego analyzed the genomes of hundreds of malaria parasites to determine which genetic variants are most likely to confer drug resistance......»»
Flour, water, salt, GitHub: The Bread Code is a sourdough baking framework
My year of baking lessons, guided by a full-stack engineer who teaches patience. One year ago, I didn’t know how to bake bread. I just knew how to follow a recipe. If everythin.....»»
Passport control for glycan maturation: Discovery of a molecular tag that enhances biopharmaceutical quality
A collaborative research group, including researchers from Nagoya City University, National Institutes of Natural Sciences, and RIKEN has uncovered a molecular tool, the "passport sequence," that significantly improves the production efficiency and q.....»»
A matter of time: New research shows how tissue development is temporally organized
When a vertebrate embryo develops, a group of cells self-organizes into the neural tube, eventually becoming the brain and the spinal cord. This involves specific signals, but how these signals are interpreted by developing cells remains unclear. A t.....»»
Cell model identifies important factor in neural development
The Wistar Institute's Alessandro Gardini, Ph.D., and lab have shed new light on how certain biological processes determine the development of neural cells. Their findings on a molecular "bridge" complex demonstrate a new level of detail in the under.....»»
Scientists synthesize unsymmetrical ureas using non-phosgene method
Unsymmetrical ureas can form multiple stable hydrogen bonds with proteins. Since drugs containing urea functional groups display unique biological activities when interacting with their targets, they play an important role in drug development and med.....»»
China experiences reduction in food system inequality and carbon footprint alongside economic development
Humans have persistent food needs that trigger considerable greenhouse gas emissions, varying significantly by region. However, the greenhouse gas (GHG) footprint and inequality in the food system are not well assessed within countries......»»
Here’s everything we know so far about Apple’s 5G modem
It’s been a long time since Apple has been working on its own 5G modem. However, development is taking much longer than the company expected – but recent evidence suggests that we’ll see Apple’s first 5G modem next year. Read on as we detail.....»»
Maritime pine seeds remember temperature conditions
The seeds of maritime pines remember the temperatures they experienced during early development. This memory persists in young trees for at least two years after germination. The above discovery was made by researchers at INRAE, CEA, FCBA, the Univer.....»»
Better health diagnostics through genetically engineered embedded sentinel cells
Cells can now be genetically programmed to record their histories within their genomes, a development that could revolutionize the study of developmental and disease processes, according to a collaborative work by researchers from multiple institutio.....»»
Two-way water transfers can ensure reliability and save money during drought in Western US
A study led by researchers at the University of North Carolina at Chapel Hill offers a solution to water scarcity during droughts amid the tug of economic development, population growth and climate uncertainty for water users in Western U.S. states......»»
Domain security posture of Forbes Global 2000 companies
In this Help Net Security video, Vincent D’Angelo, Global Director of Corporate Development and Strategic Alliances with CSC, analyzes the domain security of the Forbes Global 2000. CSC’s 2024 Domain Security Report analyzes the highest and lowes.....»»
Bitwarden enhances inline autofill features to simplify account creation
Bitwarden further strengthened inline autofill capabilities within its browser extension. Users can easily generate and autofill strong, unique passwords for new accounts directly from the inline autofill menu. This update eliminates the need for man.....»»
Trump targets Mexico and Canada with tariffs, plus an extra 10% for China
Tariffs are retaliation for drug trafficking and illegal migration. Donald Trump has said he will impose tariffs of 25 percent on all imports from Canada and Mexico, and an extra.....»»
Researchers develop light-guided siRNA delivery system based on cyanobacteria
In a study published in Cell Reports Physical Science on Nov. 25, a research team reported the development of an innovative intelligent light-guided biohybrid system, the CTPA/siCSF1R system, to target tumor-associated macrophages (TAMs), thus enabli.....»»
Transformation of UN goals only way forward for sustainable development, say researchers
Climate change is the single biggest threat to the global environment and socio-economic development—demanding an urgent transformation of the United Nations' Sustainable Development Goals (SDGs), according to a new study......»»
New mechanism in bacterial DNA enzyme opens pathways for antibiotic development
Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Center have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic target. This enzyme, present in bacteria but absent i.....»»
New transformer-based AI model enhances precision in rice leaf disease detection
Rice is one of the world's most essential food crops, but its production is constantly threatened by leaf diseases caused by pathogens such as fungi, bacteria, and viruses. These diseases, which manifest as spots or blotches on leaves, can severely i.....»»
Scientists develop AI tool for personalized phage therapy as a targeted alternative to antibiotics
With the rapid development of antibiotics in the 1930s, phage therapy—using viruses known as bacteriophages or phages to tackle bacterial infections—fell into oblivion. But as the current rise in antibiotic resistance is making it increasingly di.....»»