New enzyme could mean better drugs
Just as a choreographer's notation tells a dancer to strike a particular pose, an enzyme newly discovered by Rice University scientists is able to tell specific molecules precisely how to arrange themselves, down to the angle of single hydrogen bonds.....»»
Assessing the efficacy of clinical drugs targeting SARS-CoV-2 main protease
Over the last few years, the SARS-CoV-2 virus, responsible for COVID-19, has undergone significant changes, evolving from the original wild-type strains to the highly transmissible omicron variant......»»
Enzyme engineering has the potential to drive more sustainable and efficient drug manufacturing
Researchers have found a new way to use biocatalysis to improve the production of critical raw materials required for essential drugs, making the process quicker, more efficient, and environmentally friendly. Biocatalysis is a process that uses enzym.....»»
Drugmaker shut down after black schmutz found in injectable weight-loss drug
The warning comes amid a legal war over compounded weight-loss drugs. The Food and Drug Administration is warning consumers not to use any drugs made by a compounding pharmacy in.....»»
New nanocatalyst targets tumors without oxygen
Tumors often contain areas of oxygen-deficient tissue that frequently withstand conventional therapies. This is because the drugs applied in tumors require oxygen to be effective. An international research team has developed a novel mechanism of acti.....»»
Single-molecule tracking technology streamlines drug discovery
New drug discovery is a critical step for improving patients' lives. First, researchers must identify molecules in the body's cells that help drive disease, as these are potential targets for new drugs. The next step is to screen candidate drugs that.....»»
Using machine learning to identify bacterial resistance genes and the drugs to block them
Antibiotic resistance is a growing public health problem around the world. When bacteria like E. coli no longer respond to antibiotics, infections become harder to treat......»»
Ars Live: What else can GLP-1 drugs do? Join us today for a discussion.
Dr. Daniel Drucker will discuss what's ahead for these blockbuster drugs. News and talk of GLP-1 drugs are everywhere these days—from their smash success in treating Type 2 diab.....»»
How can you write data to DNA without changing the base sequence?
A new method lets anyone with a kit write data to DNA with just one enzyme. Zettabytes—that’s 1021 bytes—of data are currently generated every year. All of those cat videos.....»»
Glycans can regulate their own biosynthesis by modifying enzyme activity
Glycans are chains of sugars that attach to cells through proteins or lipids, changing their chemical characteristics. Glycans can be incredibly complex and branched in structure, contributing to the stability of the extracellular domain of cells and.....»»
Discovery of critical iron-transport protein in malaria parasites could lead to faster-acting medications
Malaria kills over 600,000 people a year, and as the climate warms, the potential range of the disease is growing. While some drugs can effectively prevent and treat malaria, resistance to those drugs is also on the rise......»»
Did Decriminalizing Drugs Such As Fentanyl Cause Opioid Overdose Increase?
Oregon decriminalized hard drugs in 2021 and recriminalized them last month. A new analysis shows the laws likely had little effect on opioid deaths.....»»
The Unsettled Science behind Weight-Loss Drugs for Teens
Wegovy and similar weight-loss medications are becoming widely prescribed for teenagers with obesity, but little is known about their long-term effects.....»»
Unique multidomain enzymes from bacteria identified
Pharmaceutical scientists from the National University of Singapore (NUS) have identified and characterized a unique multidomain enzyme capable of catalyzing two distinct types of reactions, both vital for making drug molecules......»»
Ars Live: What else can GLP-1 drugs do? Join us Tuesday for a discussion.
Dr. Daniel Drucker will discuss what ahead for these blockbuster drugs. News and talk of GLP-1 drugs are everywhere these days—from their smash success in treating Type 2 diabet.....»»
Natural compound found in flowers blocks activity of an enzyme involved in multiple sclerosis and cancer
Scientists have identified a natural compound that halts the process involved in the progression of certain forms of cancer and demyelinating conditions—those that damage the sheath, known as myelin, that surrounds neurons—such as multiple sclero.....»»
VW China marketing chief Jochen Sengpiehl deported after drugs test
Veteran marketing executive Jochen Sengpiehl's future at VW is uncertain. The automaker has launched an internal investigation after he was deported to Germany from China......»»
Studies of migraine’s many triggers offer paths to new therapies
One class of drugs has already found success in treating the painful, common attacks. For Cherise Irons, chocolate, red wine, and aged cheeses are dangerous. So are certain sounds.....»»
Cellular senescence research identifies key enzyme to promote healthy aging
A team at Kumamoto University has made a discovery that could help promote healthy aging. As the world's population ages, Japan's aging population in particular is growing at an unprecedented rate, making it crucial to extend healthy lifespans rather.....»»
More efficient phenotypic screening method can simultaneously test multiple drugs
Some of the most widely used drugs today, including penicillin, were discovered through a process called phenotypic screening. Using this method, scientists are essentially throwing drugs at a problem—for example, when attempting to stop bacterial.....»»
Drugmakers can keep making off-brand weight-loss drugs as FDA backpedals
FDA is reviewing its decision to remove tirzepatide drugs from the shortage list. Facing a lawsuit, the Food and Drug Administration has decided to reconsider its decision to take.....»»