New enzyme could mean better drugs
Just as a choreographer's notation tells a dancer to strike a particular pose, an enzyme newly discovered by Rice University scientists is able to tell specific molecules precisely how to arrange themselves, down to the angle of single hydrogen bonds.....»»
With 145 sickened, 2 dead, microdosing candy poisonings are still a mystery
FDA keeps testing—and keeps finding new drugs. But they don't explain the cases. Enlarge (credit: Diamond Shruumz) The number of poisonings connected to Diamond Shruumz-brand microdosing candies has reached 145 cases a.....»»
Novel carbon nanohorn-based treatment enables efficient delivery of drugs in cancer therapy
Cancer remains one of the most challenging diseases to treat due to its complexity and tendency to metastasize (spread into, or invade, nearby tissues or distant places in the body to form new tumors). Traditional therapies, such as chemotherapy and.....»»
Roundworm study paves way for better RNA-based drugs to treat human disease
RNA interference (RNAi) therapeutics have garnered significant attention in clinical research due to their potential for treating various diseases, including genetic disorders, viral infections and cancer. These therapeutics can target and silence di.....»»
Medicare drug price negotiations: 10 list prices drop between 38% to 79%
If the prices were set in 2023, Medicare would have saved $6 billion. Enlarge / Prescription drugs are displayed at NYC Discount Pharmacy in Manhattan on July 23, 2024. (credit: Getty | Spencer Platt) In the first round.....»»
Big-name drugs see price drops in first round of Medicare negotiations
If the prices were set in 2023, Medicare would have saved $6 billion. Enlarge / Prescription drugs are displayed at NYC Discount Pharmacy in Manhattan on July 23, 2024. (credit: Getty | Spencer Platt) In the first round.....»»
Trojan horse method gives malaria parasites a taste of their own medicine
More than a quarter of Australians over the age of 50 take cholesterol-lowering drugs to prevent heart disease and strokes, but our bodies also need cholesterol to survive. Now, scientists from The Australian National University (ANU) say its role as.....»»
Supplements Companies Are Cashing In on the Ozempic Wave
With demand for GLP-1 drugs sky-high, the supplement industry is elbowing into the market. Some products are meant to complement meds like Ozempic. Others are positioned as “natural” alternatives......»»
Chemists synthesize plant-derived molecules that hold potential as pharmaceuticals
MIT chemists have developed a new way to synthesize complex molecules that were originally isolated from plants and could hold potential as antibiotics, analgesics, or cancer drugs......»»
Developing a simple, cost-effective method to identify the targets of a crucial protein-modifying enzyme
Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at EMBL Grenoble have developed a new method to study a.....»»
A common parasite could deliver drugs to the brain—how scientists are turning Toxoplasma gondii from foe into friend
Parasites take an enormous toll on human and veterinary health. But researchers may have found a way for patients with brain disorders and a common brain parasite to become frenemies......»»
How Do You Get Drugs to the Brain? Maybe Try a Parasite
A common parasite could one day deliver drugs to the brain. Here's how scientists are turning Toxoplasma gondii from foe into friend......»»
The Benefits of Ozempic Are Multiplying
There’s mounting evidence that GLP-1 drugs have health benefits beyond diabetes and weight loss, for conditions ranging from addiction to Parkinson’s—and scientists are evolving theories of why......»»
Predicting metabolic potential in bacteria from limited genome data
How bacteria eat food, and what kinds of products they can make from that food, is dictated by the metabolic network of enzyme patterns encoded in their genomes. Using computational methods to learn these patterns across a large number of known bacte.....»»
Treatments for ‘Brain-Eating’ Amoebas Are on the Horizon
New drugs may help patients with life-threatening "brain-eating" amoeba infections.....»»
Fungi adapt cell walls to evade antifungal drugs
Every year, life-threatening invasive fungal infections afflict more than 2 million individuals globally. Mortality rates for these infections are high, even when patients receive treatment......»»
NYC"s Eighth Avenue plagued by crime, drugs, violence: "This part is getting bad"
NYC"s Eighth Avenue plagued by crime, drugs, violence: "This part is getting bad".....»»
Man suffers heart problem after rapid weight loss: A GLP-1 cautionary tale
The man developed atrial fibrillation and required hospitalization. Enlarge (credit: Getty | Spauln) The dose makes the medicine—and for many critical prescription drugs, the dose depends on a patient's body weight. Us.....»»
Path to precision: Targeted cancer drugs go from table to trials to bedside
What started in a scientist's dining room is now in tissue-agnostic combo trials. Enlarge (credit: Aurich Lawson) In 1972, Janet Rowley sat at her dining room table and cut tiny chromosomes from photographs she had taken.....»»
Buying shady weight loss drugs online is a bad idea, in case you were wondering
Buying shady weight loss drugs online is a bad idea, in case you were wondering.....»»
Scientists reveal transport mechanism of norepinephrine transporter and binding mode of small molecule and peptide drugs
Noradrenaline (NA) is an important monoamine neurotransmitter in the nervous system. The noradrenaline transporter (NET) located on the presynaptic membrane can transport NA into presynaptic neurons......»»