How Do You Get Drugs to the Brain? Maybe Try a Parasite
A common parasite could one day deliver drugs to the brain. Here's how scientists are turning Toxoplasma gondii from foe into friend......»»
Brain cells mature faster in space but stay healthy: ISS study
Microgravity is known to alter the muscles, bones, the immune system and cognition, but little is known about its specific impact on the brain. To discover how brain cells respond to microgravity, Scripps Research scientists, in collaboration with th.....»»
Unlocking the brain: Peptide-guided nanoparticles deliver mRNA to neurons
Penn Engineers have modified lipid nanoparticles (LNPs)—the revolutionary technology behind the COVID-19 mRNA vaccines—to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthroug.....»»
Werner Herzog muses on mysteries of the brain in Theater of Thought
Auteur director's latest documentary runs the gamut from BCIs and how we construct reality to whether fish can dream. Werner Herzog has made more than 60 films over his illustriou.....»»
The science of shopping: Neuroeconomist explains what happens in the brain when we buy
'Tis the season for spending for many. An estimated 197 million people shopped from Black Friday to Cyber Monday, according to the National Retailer Federation. On Black Friday alone, consumers spent a record $33.6 billion......»»
Weight loss drugs may also treat addiction, Alzheimer’s, and heart disease
Pharmaceutical companies are already cashing in on their other health benefits. One of Dr. Mo Sarhan’s patients was experiencing intense cravings for opioids and alcohol when th.....»»
Obesity rates are down. Is that because of weight-loss drugs?
Results from a recent survey have prompted questions. Earlier this fall, the Centers for Disease Control and Prevention reported data showing that adult obesity rates—long trend.....»»
Not so simple machines: Cracking the code for materials that can learn
It's easy to think that machine learning is a completely digital phenomenon, made possible by computers and algorithms that can mimic brain-like behaviors. But the first machines were analog and now, a small but growing body of research is showing th.....»»
Analysis provides new insights into the replication of BK polyomavirus, a major cause of kidney transplant failure
BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV. Research at the University of Alabama at Birmingham reveals new aspects of BKPyV replication, offering possible drug targets to pro.....»»
In vivo electrochemistry could provide early detection of high-altitude hypoxic brain injury
People who climb too fast or too high risk acute altitude sickness, which can lead to life-threatening hypoxic brain injury. By using in vivo electrochemistry, researchers have demonstrated that characteristic changes occur in the oxygen content of v.....»»
A new method for efficient synthesis of anti-cancer drugs
The Wadsworth–Emmons (HWE) reaction is a fundamental reaction in organic chemistry, widely used to create conjugated carbonyl compounds. Conjugated carbonyl compounds are used in many industries for synthesizing perfumes, plastics, and pharmaceutic.....»»
HowStuffWorks founder Marshall Brain sent final email before sudden death
Popular tech educator died in his office within hours of claiming retaliation for filing NCSU ethics reports. The week before Thanksgiving, Marshall Brain sent a final email to hi.....»»
Enzyme study sheds light on the molecular mechanism behind "sleepiness"
Recent research has observed that chemical modifications called phosphorylation of proteins in brain neurons dynamically regulate sleep and wakefulness. But the protein kinases that suppress sleep and the dephosphorylation enzymes that control sleep.....»»
How did human brains get so big? The answer could be in our gut
Brain tissue is among the most energetically costly in the body, and as a result, larger-brained mammals require more energy to support brain growth and maintenance. Exactly which biological changes allowed human ancestors to meet the very high needs.....»»
Seeing is believing: Leveraging defining morphological features for accurate selection of brain organoids
By combining morphological and single-cell level gene expression analyses, a team of researchers led by Professor Jun Takahashi in the Department of Clinical Application at Kyoto University has established a new non-destructive system to select high-.....»»
Parasite genome analysis provides a new approach to predicting malaria drug resistance
Researchers at University of California San Diego analyzed the genomes of hundreds of malaria parasites to determine which genetic variants are most likely to confer drug resistance......»»
People with brain injuries have a high risk of romance scams. "Scambassadors" can help shed stigma
Romance scams—where scammers create fake identities and use dating or friendship to get your trust and money—cost Australians A$201 million last year......»»
A matter of time: New research shows how tissue development is temporally organized
When a vertebrate embryo develops, a group of cells self-organizes into the neural tube, eventually becoming the brain and the spinal cord. This involves specific signals, but how these signals are interpreted by developing cells remains unclear. A t.....»»
Scientists synthesize unsymmetrical ureas using non-phosgene method
Unsymmetrical ureas can form multiple stable hydrogen bonds with proteins. Since drugs containing urea functional groups display unique biological activities when interacting with their targets, they play an important role in drug development and med.....»»
Decoding the structure of nano "gene ferries" to advance RNA drugs
LMU researchers have investigated how cationic polymers organize on a molecular level when transporting RNA drugs......»»
Taming big data and particle beams: How researchers are pushing AI to the edge
Every day, researchers at the Department of Energy's SLAC National Accelerator Laboratory tackle some of the biggest questions in science and technology—from laying the foundations for new drugs to developing new battery materials and solving big d.....»»