Getting protein factories to run—How deubiquitinating enzymes moonlight as Fubi proteases
The small protein ubiquitin is particularly famous for marking proteins for degradation but it has also been shown to regulate virtually all cellular processes. In parallel to the ubiquitin system various other ubiquitin-like modifiers have evolved,.....»»
Scientists investigate fast reaction dynamics in synthetic molecules immobilized in porous protein cages
Immobilizing small synthetic molecules inside protein crystals proves to be a promising avenue for studying intermediate compounds formed during chemical reactions, report scientists from Tokyo Tech. By integrating this method with time-resolved seri.....»»
Pongamia trees grow where citrus once flourished, offering renewable energy and plant-based protein
An ancient tree from India is now thriving in groves where citrus trees once flourished in Florida, and could help provide the nation with renewable energy......»»
Researchers reveal how plants protect themselves from viral infection by regulating deacetylation
In a paper published in Science Bulletin, a team of Chinese scientists demonstrated that TaSRT2 recognized viral protein P153 and induced wheat resistance to CWMV through inhibition of the TaSRT2-mediated deacetylation of H3K9ac and H3K79ac, which ev.....»»
Pear-derived discovery: A genetic mechanism to fortify crops against drought
A recent study has shed light on a critical genetic mechanism that boosts plants' ability to withstand drought. The research uncovers the role of the transcription factor PbERF3, native to wild pears, which works in concert with the protein PbHsfC1a.....»»
Study finds ways to enhance transcription factor activity
Transcription factors regulate gene expression by binding specific sequences on DNA, which is an essential step to producing messenger RNAs from protein-coding genes. Denes Hnisz's lab, in collaboration with Martin Vingron's lab at the MPIMG, has dis.....»»
New mRNA technology turns cells into long-lasting drug factories
A team of researchers has established a ribonucleic acid (RNA)-based method that drives cells in the body to produce therapeutic proteins and secrete them into the bloodstream. The approach could potentially extend the lifespan of drugs in the body,.....»»
Researchers uncover protein SRSF1"s uncommon ability to bind and unfold RNA G-quadruplexes
RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence. In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department of Chemistry Professor Jun Zhang, Ph.D., and his te.....»»
New modified CRISPR protein can fit inside virus used for gene therapy
Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells. Hongjian Wang and colleagues a.....»»
Novel method for mass production of recombinant proteins uses mono-sodium glutamate
Mass production of recombinant proteins using yeast cell "factories" needs methanol, a compound that requires safe handling, carries the risk of catching fire, and sometimes produces harmful byproducts. Researchers at the Department of Biochemistry (.....»»
Understanding how zwitterionic polymers can lead to safer drugs and disease prevention
Proteins are vital biomolecules responsible for performing various functions in the human body and are thus regarded as the workhorses of a cell. The primary structure of a protein is composed of different amino acids coming together. The structure s.....»»
Researchers apply quantum computing methods to protein structure prediction
Researchers from Cleveland Clinic and IBM have recently published findings in the Journal of Chemical Theory and Computation that could lay the groundwork for applying quantum computing methods to protein structure prediction......»»
Insect frass becomes food for protein-rich microalgae
As the demand for protein-rich food increases with population growth and rising awareness of nutrition and health, traditional animal and plant-based protein sources that require arable land or freshwater put significant pressure on land and resource.....»»
A new Hungarian method may aid protein research
In a paper recently published in Nature Communications, the HUN-REN-ELTE Protein Modeling Research Group (Institute of Chemistry) has laid the foundations for a mathematical method, allowing the computer-assisted comparison of the three-dimensional s.....»»
Scientists elucidate substrate recognition and proton coupling mechanism of transporter protein VMAT2
Vesicular monoamine transporter 2 (VMAT2) is the only transporter protein in the central nervous system that mediates the storage of monoamine neurotransmitters. It plays a critical role in mediating nerve impulse transmission and neuroprotection......»»
DNA repair mechanism further elucidated in cryo-electron microscopy experiment
Researchers have discovered how the protein XPD detects severe DNA damage and controls its repair......»»
Who will like beetle skewers? What Europeans think about alternative protein food
Why do people in Paris like seaweed and tofu salad? Will Italians be tempted to try a beetle skewer? How many young Polish consumers are "food innovators," eager to eat chickpea pâté? In an international project, researchers from SWPS University an.....»»
A man who lost 40 pounds — and cut 10 inches from his waistline — recommends walking, protein swaps, and drinking vinegar water
A man who lost 40 pounds — and cut 10 inches from his waistline — recommends walking, protein swaps, and drinking vinegar water.....»»
Unveiling a novel AAK1 inhibitor: How chemical proteomics unlock therapeutic potential
Enhancing drug development for life-threatening diseases like cancer hinges on a deep understanding of protein kinases, making it a focal point for researchers. These enzymes, encoded by more than 500 human genes, serve as critical players in cellula.....»»
New jobs in doubt as Ford and GM change plans for massive Michigan EV factories
Delays and fewer jobs have become recurring themes for high-profile automotive projects in Michigan, which has bet billions of dollars in taxpayer-funded incentives on the EV transition......»»
Redwood partners with GM joint venture Ultium to recycle battery scrap
Production scrap from cell factories in Ohio and Tennessee will be recycled. Enlarge / These minerals were once part of lithium-ion battery cells and will be once again. (credit: Redwood Materials) Battery recycling comp.....»»