Getting protein factories to run—How deubiquitinating enzymes moonlight as Fubi proteases
The small protein ubiquitin is particularly famous for marking proteins for degradation but it has also been shown to regulate virtually all cellular processes. In parallel to the ubiquitin system various other ubiquitin-like modifiers have evolved,.....»»
Protein signaling pathway provides insights into cell migration and cancer metastasis
The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a village: a combination of physical barriers, chemical attacks, and an army of specialized white blood cells. But maintaining and.....»»
Cryo-electron microscopy sheds light on endothelin signaling mechanisms
Endothelin is a peptide hormone known for its vasoconstrictive effects. Researchers at University of Tsukuba used cryo-electron microscopy to examine the complex structure of the endothelin receptor and G protein, which are crucial for signal transdu.....»»
Las Vegas woman mistakenly told husband died in hit-and-run crash
Las Vegas woman mistakenly told husband died in hit-and-run crash.....»»
MicroRNA, Protein Folding and Machine-Learning Work Win the Science Nobels
A roundup of the science Nobels, the latest COVID updates and the Europa Clipper launch delay......»»
Climate-Fueled Disasters Are Raising Insurance Rates
Increasingly intense hurricanes, wildfires and other climate disasters have forced these state-run backstop insurance groups into a role typically assumed by the private sector as the primary insurer within their borders.....»»
Bad Monkey creators talk seasons 2 and 3 for Apple TV+
Bad Monkey has been another hit for Apple, occupying the top of the Apple TV+ charts throughout much of its first season run. In a recent interview, its co-creators shared some good news about plans for the continuation of the show into season 2 and.....»»
Amazon’s first color Kindle e-reader, the Kindle Colorsoft, will run you $280
High price, but it's in line with what Amazon has charged for older premium Kindles. Amazon is overhauling its entire Kindle e-reader lineup today. And nestled among the nice-but-.....»»
Future iPhones getting even more memory: 12GB from next year
This year’s entire iPhone 16 line-up got 8GB RAM to run Apple Intelligence features, and it looks like we can expect 12GB in future models. A previous report suggested that iPhone 17 Pro Max would get 12GB, and it now appears that this may be tr.....»»
Each glacier has a unique organic matter composition, study reveals
Melting glaciers release more than just water. Organic matter once trapped in ice can run into streams and rivers, where it becomes food for microbes. These organisms respire the organic matter back to the atmosphere in the form of carbon dioxide, wi.....»»
Scientists discover chemical probes for previously "undruggable" cancer target
Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is notoriously diff.....»»
Glowing proteins enable real-time, 3-D study of essential enzymes
Working in organoid models, researchers at University of California San Diego School of Medicine have developed a new tool to study protein-kinase C (PKC) enzymes, which play a critical role in cell growth, differentiation and survival. Malfunction o.....»»
Calcium transport protein in bacteria offers insights for drug development and food safety
Researchers at Umeå University have revealed details on how bacteria use calcium to regulate vital processes in a way that differs from human cells. This breakthrough is significant in the fight against antibiotic resistance and for increasing safet.....»»
Protein USP50 identified as key in DNA replication balance
A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study......»»
Expansion in situ genome sequencing innovation makes hidden DNA-protein interactions visible
Harvard scientists have unveiled a new technique called expansion in situ genome sequencing (ExIGS) that combines existing in situ genome sequencing (IGS) with expansion microscopy (ExM). The innovation allowed researchers to link nucleus abnormaliti.....»»
Machine learning cracked the protein-folding problem and won the 2024 Nobel Prize in chemistry
The 2024 Nobel Prize in chemistry recognized Demis Hassabis, John Jumper and David Baker for using machine learning to tackle one of biology's biggest challenges: predicting the 3D shape of proteins and designing them from scratch......»»
Targeting "undruggable" diseases: Researchers reveal new levels of detail in targeted protein degradation
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, including cancers and ne.....»»
Oxidative stress: How protein recycling protects against cell death
Researchers at LMU University Hospital have discovered a new molecular switch that protects against cell death......»»
Scientists discover how innate immunity envelops bacteria
The protein GBP1 is a vital component of our body's natural defense against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat, but how the substance manages to do this has remained unknown until now......»»
Tesla says sub-$30,000 Cybercab will be "very high volume" vehicle
The autonomous taxi is expected to anchor a Tesla-run ride-share service, but it will also be available to private customers......»»
AI-driven approach challenges traditional views on protein structure
In a recently published article in Nature Communications,, a team offers an AI-driven approach to explore structural similarities and relationships across the protein universe. The team includes members from the University of Virginia—including Phi.....»»