Filament structure found to activate and regulate CRISPR-Cas "protein scissors"
CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, al.....»»
New technique points to unexpected uses for snoRNA across many cell types
Dynamic, reversible modifications of DNA and RNA regulate how genes are expressed and transcribed, which can influence cellular processes, disease development, and overall organismal health. Small nucleolar RNAs (snoRNAs) are a common but overlooked.....»»
tRNAs help some mRNAs get lost in translation
Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized and translated into more protein, while directing others to be degraded and limiting how much protein can be made. They publis.....»»
New structure gives insight into mRNA export and cancers, and how viruses hijack the process to infect their host
The central dogma of biology defines the flow of genetic information: It describes how proteins are made from mRNA templates, which are in turn made from DNA. Exporting the mRNA from inside the nucleus to the site of protein translation in the cytopl.....»»
Spatial interactomics tool maps protein interactions to fight lung cancer
As Ahmet F. Coskun and his team of researchers continue their mission to create a 3D atlas of the human body, mapping cells and tissues, they're making discoveries that could lead to better treatments for the most common type of lung cancer......»»
Scientists uncover cross-species neural mechanism for early detection of life motion in visual processing
Visual systems of both humans and animals can detect life motion from the environment at the earliest stage of visual processing, research by scientists from the Chinese Academy of Sciences (CAS) uncovered......»»
New language encodes shape and structure to help machine learning models predict nanopore properties
A large number of 2D materials like graphene can have nanopores—small holes formed by missing atoms through which foreign substances can pass. The properties of these nanopores dictate many of the materials' properties, enabling the latter to sense.....»»
Advancements in genomic research reveal alternative transcription initiation sites in thousands of soybean genes
Rosalind Franklin, James Watson and Francis Crick discovered the structure of DNA—that molecular blueprint for life—over 70 years ago. Today, scientists are still uncovering new ways to read it......»»
Cable companies and Trump’s FCC chair agree: Data caps are good for you
Data caps reflect "highly competitive environment," cable lobby tells FCC. The Federal Communications Commission's plan to investigate and potentially regulate data caps is all bu.....»»
CRISPR-based system labels extracellular vesicles with "barcodes" to better understand cell-to-cell communication
Cell-to-cell communication through nanosized particles, working as messengers and carriers, can now be analyzed in a whole new way, thanks to a new method involving CRISPR gene-editing technology......»»
How to make a video call on the Roborock Qrevo Curv
The Roborock Qrevo Curv is capable of making video calls, which is great for checking in on pets. Here's how to activate the cool feature......»»
Trump’s FCC chair is Brendan Carr, who wants to regulate everyone except ISPs
Carr says he wants to punish broadcast media and dismantle "censorship cartel." President-elect Donald Trump announced last night that he will make Brendan Carr the chairman of th.....»»
Neat, precise and brighter than ever: New technologies improve temporal coherence of XFEL pulses
X-ray free-electron lasers produce pulses of light that are exceptionally bright, making them powerful tools for studying ultrafast chemical reactions, biological processes, or probing the structure of materials at atomic scales......»»
Electron imaging reveals the vibrant colors of the outermost electron layer
Surfaces play a key role in numerous chemical reactions, including catalysis and corrosion. Understanding the atomic structure of the surface of a functional material is essential for both engineers and chemists. Researchers at Nagoya University in J.....»»
Astronomers discover a unique quasi-stellar object–dusty star-forming galaxy system
Astronomers from the Steward Observatory in Arizona and elsewhere report the discovery of a structure consisting of a quasi-stellar object (QSO) and a dusty star-forming galaxy (DSFG), linked by a bridge of ionized carbon. The finding of this unique.....»»
Archaea shape microbiomes by using molecular spring-loaded daggers
In a paper published in Science Advances, the Pilhofer Lab (IMBB) together with the Albers Lab from the University of Freiburg describe the structure and function of contractile injection systems from haloarchaea and show how it can structure the loc.....»»
Hormone receptor structure reveals how it functions in heart disease
Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable better drug targeting of the receptor for diseases such as.....»»
Can AI improve plant-based meats? Using mechanical testing and machine learning to mimic the sensory experience
Cutting back on animal protein in our diets can save on resources and greenhouse gas emissions. But convincing meat-loving consumers to switch up their menu is a challenge. Looking at this problem from a mechanical engineering angle, Stanford enginee.....»»
Topological defects can trigger a transformation from insulating to conductive behavior in Mott materials
Researchers at Università Cattolica, Brescia campus, have discovered that the transition from insulating to conductive behavior in certain materials is driven by topological defects in the structure......»»
The First Crispr Treatment Is Making Its Way to Patients
It’s been a year since the gene-editing treatment Casgevy was approved for sickle cell disease and a related blood disorder. It’s finally being infused into patients......»»
Mathematical approach can predict crystal structure in hours instead of months
Researchers at New York University have devised a mathematical approach to predict the structures of crystals—a critical step in developing many medicines and electronic devices—in a matter of hours using only a laptop, a process that previously.....»»