Getting protein factories to run—How deubiquitinating enzymes moonlight as Fubi proteases
The small protein ubiquitin is particularly famous for marking proteins for degradation but it has also been shown to regulate virtually all cellular processes. In parallel to the ubiquitin system various other ubiquitin-like modifiers have evolved,.....»»
Scientists develop novel approach to interrogate tissue-specific protein–protein interactions
Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out.....»»
Finland"s wizards making food out of thin air
At a factory in Finland, the "farmers of the future" are making a new food protein by feeding a microbe air and electricity, proving that protein can be produced without traditional agriculture......»»
Massive parts reduction is key to Tesla"s manufacturing efficiency
Tesla builds vehicles faster and with fewer parts, a manufacturing strategy that reduces cost and weight, and requires fewer workers and smaller factories......»»
Repurposed protease controls important signaling molecule-activating protein
Efficient communication between cells is vital for many biological processes, such as recruiting immune cells to combat disease. The rapid release of at least 80 signaling molecules, including tumor necrosis factor and epidermal growth factor, is con.....»»
Schools, factories closed after quake "swarm" near Naples
Factories and schools near Naples were closed for inspections Tuesday after 150 tremors, including the biggest for 40 years, hit the volcanic region in southern Italy......»»
Scientists" new drug-delivery technology is possible breakthrough for multi-strain vaccines
A new way to deliver drugs using a common protein could be used to develop mosaic vaccines, which are vaccines effective against multiple strains of a virus like COVID-19, among other medicines in a global first......»»
Comparison of four methods on drying efficiency and physicochemical properties of chicken meat
Chicken breast jerky (CBJ) is a popular pet food due to its high crude protein content and long shelf life. In the production of CBJ, the drying process is a crucial step. However, the physicochemical and functional properties of CBJ depend on the dr.....»»
By listening, scientists learn how a protein folds
By converting their data into sounds, scientists discovered how hydrogen bonds contribute to the lightning-fast gyrations that transform a string of amino acids into a functional, folded protein......»»
Scientists introduce DIProT—an interactive deep learning toolkit for efficient protein design
Scientists have developed DIProT, an innovative, user-friendly toolkit for protein design. The toolkit utilizes a non-autoregressive deep generative model to address the protein inverse folding problem, integrating human expertise into the design loo.....»»
Using hybrid nanotubes to enhance cancer treatment with intracellular protein delivery
The intracellular delivery of proteins is an important technique for unveiling the cellular functions, protein complex structure, and therapeutics. However, conventional delivery methods have several limitations......»»
Study reveals how a sugar-sensing protein acts as a "machine" to switch plant growth—and oil production—on and off
Proteins are molecular machines, with flexible pieces and moving parts. Understanding how these parts move helps scientists unravel the function a protein plays in living things—and potentially how to change its effects. Biochemists at the U.S. Dep.....»»
Protein prediction technology yields accurate results to efficiently find the best drug candidate for many conditions
Artificial intelligence (AI) has numerous applications in health care, from analyzing medical imaging to optimizing the execution of clinical trials, and even facilitating drug discovery......»»
Study reveals insights into protein evolution
Rice University's Peter Wolynes and his research team have unveiled a breakthrough in understanding how specific genetic sequences, known as pseudogenes, evolve. Their paper was published May 13 in the Proceedings of the National Academy of Sciences......»»
Protein assembly research shows molecular roll of the dice delivers winning combinations
Australian researchers have shed light on the shape-shifting capabilities of protein assemblies, with results that could revolutionize fields from biomanufacturing to vaccine development......»»
Genes spatially organize for efficient mRNA splicing, study shows
The nucleus of each of your cells contains all the genetic information (the genome) necessary to build every type of cell and protein in your entire body. Like a complex library in a tiny space 50 times smaller than the width of a human hair, genes a.....»»
DeepMind adds a diffusion engine to latest protein-folding software
Major under-the-hood changes let AlphaFold handle protein-DNA complexes and more. Enlarge / Prediction of the structure of a coronavirus Spike protein from a virus that causes the common cold. (credit: Google DeepMind) M.....»»
Exploring lysosomal biology: Current approaches and methods
Lysosomes are critical for cellular degradation, characterized by their acidic pH and array of hydrolytic enzymes. They degrade materials through endocytosis, phagocytosis, and autophagy, recycling essential components. Lysosomes also participate in.....»»
MATE transporter facilitates bitter saponin transport from cytoplasm to vacuole
Domestic soybeans serve as an important source of healthy edible plant oil and high-quality plant protein in our food culture. In addition to the well-known components of oil (approximately 20%), protein (approximately 40%), and carbohydrates (approx.....»»
White House pledges $100 million to help small suppliers shift to EV parts
The Biden administration on Monday said it will spend more than $100 million to help small and medium-sized suppliers retool or expand their factories and improve their energy and cybersecurity infrastructures......»»
Scientists use high pressure NMR spectroscopy to study structure of dynamic proteins
A pressure of 3,000 bar is applied to the cold shock protein B of Bacillus subtilis in a small tube in the NMR spectroscopy laboratory at the University of Konstanz. This is roughly three times the water pressure at the deepest point of the ocean. Th.....»»