Freeze! Executioner protein caught in the act
A new molecular 'freeze frame' technique has allowed WEHI researchers to see key steps in how the protein MLKL kills cells......»»
Scientists unlock the secrets of how a key protein converts DNA into RNA
Researchers at the Department of Energy's SLAC National Accelerator Laboratory have uncovered new insights into the fundamental mechanisms of RNA polymerase II (Pol II), the protein responsible for transcribing DNA into RNA. Their study shows how the.....»»
Protein mutant stability can be inferred from AI-predicted structures
Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI......»»
Study shows an electrically-activated protein regulates spermatogenesis
Frankenstein's monster was brought to life by the judicious application of a little electricity; and a surprising number of processes in our bodies are regulated by electrical currents too. Now, researchers from Japan reveal that electricity may play.....»»
Chloroplast manipulation: A new strategy in pathogen warfare uncovered
A recent study has unveiled the sophisticated methods pathogens use to weaken plant defenses. It shows how a pathogen's effector protein targets the chloroplast protein StFC-II, increasing its levels in chloroplasts and reducing the plant's ability t.....»»
Simulation model shows ribosome tunnel"s impact on protein structures
Researchers at University of Tsukuba have developed a new model that simulates the internal environment of a ribosome—the cellular site of protein synthesis. Using computer simulations, they have analyzed the structures of various proteins within t.....»»
Dual protein analysis approach provides potential way to slow cancer growth
Fighting cancer effectively often involves stopping cancer cells from multiplying, which requires understanding proteins that the cells rely on to survive. Protein profiling plays a critical role in this process by helping researchers identify protei.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
Research unravels dual role of membrane protein in rice ethylene signal transduction
A research team, led by Professor Zhang Jinsong from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences, revealed insights into the mechanism by which the membrane protein MHZ3 collaborates with the ethylene.....»»
A small molecular glue that increases P53 level and suppresses tumor growth in vivo
Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, and there has been a lac.....»»
Fiery Tesla Semi crash in California draws NTSB probe
The Tesla Semi ran off the road on Interstate 80 near Emigrant Gap, Calif., around 3 a.m. Aug. 19. No one was injured, but the vehicle caught fire and ignited nearby brush, closing the freeway in both directions for several hours......»»
Cryo-ET study elucidates protein folding helpers in their natural environment
Cryo-electron tomography (cryo-ET), can be used to visualize and analyze cellular structures in their natural environment. Researchers at the MPI of Biochemistry in Martinsried and the University Medical Center Göttingen have now used cryo-ET to stu.....»»
Comparing methods for extracting edible protein from mealworms
Edible insects are emerging as an alternative protein source that has various benefits compared with conventional animal sources. New research published in the Journal of Food Science compared four different methods for extracting protein from mealwo.....»»
Researchers teach artificial intelligence about frustration in protein folding
Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial intelligence (AI) technology has made it possible to predict.....»»
Original Ford Probe concept burns up after Pebble Beach appearance
The Ford Probe I, the first of several Italian-made concepts that eventually led to the production car in 1988, caught fire while being towed back to Southern California......»»
Lufthansa is using artificial sharkskin to streamline airplanes
Copying a trick from the animal kingdom can help cut aircraft emissions. Enlarge (credit: Aurich Lawson | Getty Images) Companies are often caught between wanting to cut emissions but also grow profits. But for airlines,.....»»
Cape Cod scientists delay controversial climate change project after feds raise concern
Cape Cod scientists are delaying a geoengineering project that looks to dump more than 60,000 gallons of sodium hydroxide into the ocean and has caught federal concerns around potential impacts on the ecosystem......»»
Exploring Huntington"s disease: Researchers discover that protein aggregates poke holes in the nuclear membrane
Researchers at Utrecht University in the Netherlands have identified a new way in which the toxic protein aggregates associated with Huntington's disease may damage nerve cells and cause them to die......»»
Newly discovered protein stops DNA damage
Researchers from Western University have discovered a protein that has the never-before-seen ability to stop DNA damage in its tracks. The finding could provide the foundation for developing everything from vaccines against cancer, to crops that can.....»»
Surprise finding in study of environmental bacteria could advance search for better antibiotics
In what they labeled a "surprising" finding, Johns Hopkins Medicine researchers studying bacteria from freshwater lakes and soil say they have determined a protein's essential role in maintaining the germ's shape. Because the integrity of a bacterial.....»»
AI, computation, and the folds of life: Supercomputers help train a software tool for the protein modeling community
Form follows function, and this is especially true for life's building blocks—proteins. The folds and shape of molecular proteins reveal their function in supporting life......»»