Discovery of a cellular uptake pathway for larger drug molecules
Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug's key-in-a-lock fit with its target and the drug's ability to m.....»»
Targeting "undruggable" diseases: Researchers reveal new levels of detail in targeted protein degradation
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, including cancers and ne.....»»
Study unveils cobalt(III) reaction mechanism with nitriles, opening pathways for drug development
A research team led by Professor Jaeheung Cho from the Department of Chemistry at UNIST has published a study in the Journal of the American Chemical Society reporting the reaction mechanism of cobalt(III)-based metal complexes with nitrile substance.....»»
Asteroid mining: A potential trillion-dollar industry
Earth's newest celestial neighbor has finally arrived. Astronomers using a powerful telescope in Sutherland, South Africa, first detected the 33-foot-long asteroid in August, reporting their discovery in Research Notes of the American Astronomical So.....»»
Signaling pathway discovery could lead to faster, more reliable human stem cell differentiation
A recent discovery has found a possible avenue to improve human health by better understanding how to engineer human stem cell differentiation......»»
A look into "mirror molecules" may lead to new medicines
A University of Texas at Dallas chemist and his colleagues have developed a new chemical reaction that will allow researchers to synthesize selectively the left-handed or right-handed versions of "mirror molecules" found in nature and assess them for.....»»
Climate change can alter methane emission and uptake in the Amazon
Extreme temperatures and humidity levels (excessive rain or drought) projected for the Amazon in the context of climate change may increase the volume of methane-producing microorganisms in flooded areas and reduce potential uptake of this greenhouse.....»»
Dark energy: Could the mysterious force we think of as constant actually vary over cosmic time?
,As I finished my Ph.D. in 1992, the universe was full of mystery—we didn't even know exactly what it is made of. One could argue that cosmologists had made little progress in our understanding of these basic facts since the discovery of the cosmic.....»»
Scientists explore whether smaller chromosomes lead to more segregation errors during egg cell division
Three RIKEN researchers have shed light on the cellular mechanisms underlying chromosomal abnormalities that can cause miscarriages and congenital disorders such as Down syndrome......»»
Fivecast Discovery drives better analytical outputs
Responding directly to an increased global threat environment, Fivecast launched a Discovery solution that empowers analysts and investigators across both the Government and Corporate sectors to uncover intelligence insights faster to help protect co.....»»
Psychedelic Mushrooms Are Getting Much, Much Stronger
Cultivators are turning to genetic sequencing and cellular-manipulation techniques to breed highly potent mushrooms—leaving some unprepared psychonauts in distress......»»
Drug makers can’t make knockoff weight-loss drugs anymore—and they’re mad
Compounding pharmacies could make knockoffs during shortage. But FDA says it's over. Compounding pharmacies are suing the Food and Drug Administration so they can keep making imit.....»»
Making micelles more effective for dye and drug dispersion through well-defined core-shell structures
Micelles are spherical molecular structures usually formed by amphiphilic molecules with block structure, which contain both hydrophilic and hydrophobic parts. The hydrophobic tails of these molecules cluster together to form a core, while the hydrop.....»»
NASA announces a new class of space missions: Probe explorers
NASA has sent a whole host of spacecraft across the solar system and even beyond. They range from crewed ships to orbit and to the moon to robotic explorers. Among them are a range of mission classes from Flagships to Discovery Class programs. Now a.....»»
We’re finally going to the Solar System’s most intriguing but unexplored frontier
If you've been waiting for a real mission of discovery into the unknown, this is it. I really hate to be the bearer of such bad news, but you and I will not live forever, dear rea.....»»
A Major GLP-1 Drug Shortage Is Over. Some Patients Aren’t Celebrating
Mounjaro and Zepbound are now out of shortage. This should be good news—but because so many patients are taking compounded versions of these GLP-1 medications, it’s a complicated situation......»»
Team discovers three new magnetic and helium-enriched hot subdwarf stars
An international team of astronomers reports the discovery of three new helium-enriched hot subdwarf stars with strong magnetic fields. The finding, made with the Southern African Large Telescope (SALT), is detailed in a research paper published Oct......»»
Reducing energy loss in metal nanostructures by altering geometrical dimensions
Researchers at City University of Hong Kong (CityUHK) have made a discovery that significantly reduces energy loss in metal nanostructures. By altering the geometrical dimensions of these structures, researchers have unlocked their full potential, pa.....»»
Physics team uncovers a quantum Mpemba effect with a host of "cool" implications
Initially investigating out of pure curiosity, researchers have made a discovery that bridges the gap between Aristotle's observations two millennia ago and modern-day understanding, while opening the door to a whole host of "cool"—and "cooling"—.....»»
Key molecule in wound healing identified through mapping of long non-coding RNA molecules
A new study from Karolinska Institutet and the Chinese Academy of Medical Sciences has identified an RNA molecule that is important for skin wound healing. The research, published in Nature Communications, may have implications for the treatment of h.....»»
Researchers design a drug capable of acting simultaneously against three different therapeutic targets
A study led by researchers of the Institute of Biomedicine of the University of Barcelona (IBUB) has developed a new pharmacological tool capable of simultaneously administering three oligonucleotide-based drugs, each acting against a different thera.....»»