Discovery of a cellular uptake pathway for larger drug molecules
Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug's key-in-a-lock fit with its target and the drug's ability to m.....»»
Research team develops metallodrug-antibiotic combination strategy to combat superbugs
Antimicrobial resistance (AMR) bacterial infections have become a serious problem threatening human health worldwide. The overuse of antibiotics has promoted drug-resistant mutations in bacteria, causing almost all clinically used antibiotics to deve.....»»
iFixit teardown shows what’s inside the Apple Watch Series 10
comes with a new design. Although it doesn’t look as radical as some people might have expected, the Series 10 design is significantly thinner and features larger displays. And for those curious to see what’s inside the Apple Watch Series 10, iF.....»»
Larger displays on iPhone 16 Pro and Apple Watch Series 10: Worth it?
Last month Apple introduced the latest iPhone 16 Pro and Apple Watch Series 10 models together, and they had one key upgrade in common: larger displays. I’ve been using the new, larger iPhone 16 Pro and 46mm Apple Watch Series 10 for nearly three w.....»»
Anti-glitches detected in gamma-ray pulsar PSR J1522-5735
By analyzing the data from NASA's Fermi Gamma-ray Space Telescope, Russian astronomers have detected anti-glitches in a gamma-ray pulsar designated PSR J1522-5735. The discovery, published September 28 on the pre-print server arXiv, makes PSR J1522-5.....»»
Reconstruction of fruit fly"s anterior visual pathway may lead to insights into animal navigation
UC Santa Barbara neuroscientists have reconstructed the entire anterior visual pathway of a fruit fly, a complex series of connections between the insect's eyes and the navigation center of its brain......»»
The Nobel Prize in physics is being awarded, a day after 2 Americans won the medicine prize
The Nobel Prize in physics is being awarded Tuesday, a day after two American scientists won the medicine prize for their discovery of microRNA......»»
Tunisian snail remains provide insights on a possible 7700-year-old local food tradition
A new study by Dr. Ismail Saafi from the Aix-Marseille Université provides details on the discovery of cooked snail remains at Kef Ezzahi in northern Tunisia. The snail remains, dating back approximately 7710 years, are the only known cases of snail.....»»
AI and quantum mechanics team up to accelerate drug discovery
Drug discovery is much like working a jigsaw puzzle. The chemical compounds behind drug molecules must be shaped to fit with the proteins in our bodies to produce therapeutic effects. That requirement for a meticulous fit means the creation of new dr.....»»
Perseverance team revives SHERLOC instrument to help with Jezero crater discovery
In January 2024, the SHERLOC instrument aboard NASA's Mars 2020 Perseverance rover encountered a significant issue. A fault in the instrument's motor caused the dust cover and autofocus mechanism to become inoperative, putting the rover's SHERLOC Ram.....»»
Researchers say life expectancy nearing its limit
Humanity is hitting the upper limit of life expectancy, according to a new study. Advances in medical technology and genetic research—not to mention larger numbers of people making it to age 100—are not not translating into marked jumps in lifesp.....»»
Nobel Prize in medicine awarded for discovery of microRNAs, the molecules that control our genes
Two scientists, Victor Ambros (UMASS Chan Medical School in the US) and Gary Ruvkun (Harvard Medical School in the US), have won the 2024 Nobel prize in medicine or physiology......»»
SCOTUS denial ends saga of Shkreli’s infamous 5,000% drug price scheme
The Supreme Court offered no explanation for denying the petition. The legal saga over Martin Shkreli's infamous 5,000 percent price hike of a life-saving anti-parasitic drug has.....»»
Winning the Nobel "an earthquake", says Ruvkun
US scientist Gary Ruvkun, who on Monday won the Nobel Prize in Medicine with fellow American Victor Ambros for their discovery of microRNA, said winning the honor was like "an earthquake"......»»
NASA"s Europa Clipper spacecraft will investigate whether an icy moon of Jupiter can support alien life
Discovering extraterrestrial life would be one of the most profound scientific and philosophical revelations that our species has ever made. But such a big discovery won't come easy. Our starting point is to first search other worlds for signs of hab.....»»
Trees" own beneficial microbiome could lead to discovery of new treatments to fight citrus greening disease
Citrus trees showing natural tolerance to citrus greening disease host bacteria that produce novel antimicrobials that can be used to fight off the disease, our recent study shows. We found the trees at an organic farm in Clermont, Florida......»»
New Kuiper Belt objects lurk farther away than we ever thought
Earth's Kuiper Belt appears to be substantially larger than we thought. In the outer reaches of the Solar System, beyond the ice giant Neptune, lies a ring of comets and dwarf pla.....»»
Phage cocktail shows promise against drug-resistant bacteria
Researchers have a new battle tactic to fight drug-resistant bacterial infections. Their strategy involves using collections of bacteriophages, viruses that naturally attack bacteria. In a new study, researchers at the University of Chicago Pritzker.....»»
Making an RSV Vaccine Was Hard. Getting People to Take It Is Even Harder
New vaccines could help stem the spread of respiratory syncytial virus, but there are already huge inequities in access and uptake......»»
Cellular agriculture research manages to culture pork fat tissue on rye protein scaffolds
National University of Singapore (NUS) food scientists have developed a simple and scalable method for culturing pork fat tissue using protein scaffolds made from secalin, a protein extracted from rye......»»
Fused molecules could serve as building blocks for safer lithium-ion batteries
By fusing together a pair of contorted molecular structures, Cornell researchers have created a porous crystal that can uptake lithium-ion electrolytes and transport them smoothly via one-dimensional nanochannels—a design that could lead to safer s.....»»