Chemokine receptor CX3CR1 structures uncover mechanism of cholesterol regulation in activation
Chemokine receptors regulate the migration of immune cells and are involved in inflammation, tumor construction and pathogen infection. Chemokines are divided into four subfamilies according to the number and distribution of conserved cysteines at th.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
What makes a supercluster?
By eye, it's impossible to pick out the exact boundaries of the superclusters, which are among the largest structures in the universe. But that's because they are not defined by their edges, but by the common motion of their components......»»
Researchers discover rejuvenation mechanism in unicellular organisms
A team of scientists from the Cluster of Excellence "Balance of the Microverse" has discovered a previously unknown rejuvenation mechanism in unicellular organisms. They studied unicellular microalgae, which serve as the basis of food chains in the o.....»»
Adversaries love bots, short-lived IP addresses, out-of-band domains
Fastly found 91% of cyberattacks – up from 69% in 2023 – targeted multiple customers using mass scanning techniques to uncover and exploit software vulnerabilities, revealing an alarming trend in attacks spreading across a broader target base. In.....»»
Scientists discover novel receptor recognition mechanism for alphavirus
Eastern Equine Encephalitis virus (EEEV), an alphavirus, can cause central nervous system infections that can lead to severe encephalitis with a mortality rate of over 30%......»»
Scientists call for an update in environmental decision making that takes human rights into account
Human well-being is connected to nature for food, climate regulation and culture, making the protection of nature a human rights matter......»»
Research unravels dual role of membrane protein in rice ethylene signal transduction
A research team, led by Professor Zhang Jinsong from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences, revealed insights into the mechanism by which the membrane protein MHZ3 collaborates with the ethylene.....»»
Single nucleosomes tracked in live cells during cell division using super-resolution microscopy
Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism by which DNA condenses during mitosis is still poor.....»»
Peloton announces $95 “used equipment activation fee”
"Completely ridiculous." Enlarge (credit: Peloton) Peloton will start charging people a one-time $95 "used equipment activation fee" for used bikes purchased from outside of Peloton and its official distribution partner.....»»
Apple splits App Store team in two, introduces new leadership
This is the latest in a series of changes resulting from EU regulation. Enlarge / The Apple Park campus in Cupertino, California. (credit: Anadolu Agency | Getty) Apple is comprehensively restructuring its long-standing.....»»
Cryo-ET study elucidates protein folding helpers in their natural environment
Cryo-electron tomography (cryo-ET), can be used to visualize and analyze cellular structures in their natural environment. Researchers at the MPI of Biochemistry in Martinsried and the University Medical Center Göttingen have now used cryo-ET to stu.....»»
Self-repairing mitochondria use novel recycling system, study finds
Mitochondria depend on a newly discovered recycling mechanism identified by scientists at The Hospital for Sick Children (SickKids)......»»
Study shows effective regulation and monitoring is key to tackling emissions of a super-greenhouse gas
New research has revealed factories globally are not properly destroying one of the most potent greenhouse gases emitted from the production of fluoropolymers like Teflon, and refrigerants......»»
Surprising mechanism for removing dead cells identified
Billions of our cells die every day to make way for the growth of new ones. Most of these goners are cleaned up by phagocytes—mobile immune cells that migrate where needed to engulf problematic substances. But some dying or dead cells are consumed.....»»
OpenCTI: Open-source cyber threat intelligence platform
OpenCTI is an open-source platform designed to help organizations manage their cyber threat intelligence (CTI) data and observables. The platform structures its data using a knowledge schema built on the STIX2 standards. It features a modern web appl.....»»
Habitat connectivity drives panda recovery, finds study
In a study published in Current Biology on August 9, a research team led by Prof. Wei Fuwen from Jiangxi Agricultural University and the Institute of Zoology of the Chinese Academy of Sciences, revealed the mechanism and process of giant panda (Ailur.....»»
The Quest to Uncover the Secrets of Gold Hydrogen
Industries want to harvest naturally occurring hydrogen as soon as possible, but scientists warn of unforeseen consequences......»»
Novel ratchet mechanism uses a geometrically symmetric gear driven by asymmetric surface wettability
The ratchet mechanism is a fascinating energy-conversion system that converts disorderly or random motion into orderly, directed movement through a process known as spontaneous rectification. It is a critical component of mechanical systems, typicall.....»»
Physicists successfully observe Kibble–Zurek scaling in an atomic Fermi superfluid
The Kibble–Zurek (KZ) mechanism is a theoretical framework introduced by physicists Tom Kibble and Wojciech Zurek. This framework essentially describes the formation of topological defects while systems undergo non-equilibrium phase transitions......»»
Morphable materials: Researchers coax nanoparticles to reconfigure themselves
A view into how nanoscale building blocks can rearrange into different organized structures on command is now possible with an approach that combines an electron microscope, a small sample holder with microscopic channels, and computer simulations, a.....»»