Zeroing in on the workings of tumor suppressor protein p53, the "guardian of the genome"
The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and cell death. Now, FMI resea.....»»
DNA repair mechanism further elucidated in cryo-electron microscopy experiment
Researchers have discovered how the protein XPD detects severe DNA damage and controls its repair......»»
Who will like beetle skewers? What Europeans think about alternative protein food
Why do people in Paris like seaweed and tofu salad? Will Italians be tempted to try a beetle skewer? How many young Polish consumers are "food innovators," eager to eat chickpea pâté? In an international project, researchers from SWPS University an.....»»
A man who lost 40 pounds — and cut 10 inches from his waistline — recommends walking, protein swaps, and drinking vinegar water
A man who lost 40 pounds — and cut 10 inches from his waistline — recommends walking, protein swaps, and drinking vinegar water.....»»
Epigenetic insights: How hybrid poplar regenerates shoots
Understanding plant regeneration at the molecular level is pivotal for advancements in genetic transformation and genome editing. Previous studies have underscored the importance of DNA methylation in model organisms, yet the specific mechanisms in w.....»»
Researchers reconstruct genome of extinct species of flightless bird that once roamed the islands of New Zealand
A team of evolutionary biologists at Harvard University, working with colleagues from the Max Planck Institute for Biological Intelligence, East Carolina University, Osaka University and the University of Toronto, has reconstructed the genome of an e.....»»
Unveiling a novel AAK1 inhibitor: How chemical proteomics unlock therapeutic potential
Enhancing drug development for life-threatening diseases like cancer hinges on a deep understanding of protein kinases, making it a focal point for researchers. These enzymes, encoded by more than 500 human genes, serve as critical players in cellula.....»»
New resource pinpoints inner workings of sorghum plant cells for designing better bioenergy feedstock
Bioenergy sorghum is an important resource for the production of biofuels and bioproducts and a critical component of a sustainable agricultural future. Researchers have been working hard to make this tall, drought-tolerant plant even more productive.....»»
New "atlas" provides unprecedented insights on how genes function in early embryo development
Although the Human Genome Project announced the completed sequencing of 20,000 human genes more than 20 years ago, scientists are still working to grasp how fully formed beings emerge from basic genetic instructions......»»
Pineapple mint"s genetic blueprint: A comprehensive genome assembly
Mentha suaveolens, commonly known as pineapple mint, is valued for its distinct aroma and medicinal properties, which are attributed to its essential oils......»»
Scientists develop novel approach to interrogate tissue-specific protein–protein interactions
Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out.....»»
Finland"s wizards making food out of thin air
At a factory in Finland, the "farmers of the future" are making a new food protein by feeding a microbe air and electricity, proving that protein can be produced without traditional agriculture......»»
Research improves multiplex mutagenesis to increase experimental efficiency in plant genome editing
CRISPR/Cas9 remains the most powerful tool to generate mutations in plant genomes. Studying the various combinations of mutations has significantly increased the scale of experimental setups, necessitating more space to grow numerous plants......»»
Repurposed protease controls important signaling molecule-activating protein
Efficient communication between cells is vital for many biological processes, such as recruiting immune cells to combat disease. The rapid release of at least 80 signaling molecules, including tumor necrosis factor and epidermal growth factor, is con.....»»
Scientists" new drug-delivery technology is possible breakthrough for multi-strain vaccines
A new way to deliver drugs using a common protein could be used to develop mosaic vaccines, which are vaccines effective against multiple strains of a virus like COVID-19, among other medicines in a global first......»»
Designing a tiny new tool to map and treat children"s brain cancer
Medulloblastoma is the most common cancerous brain tumor in children, and fighting it requires an approach that is delicate, durable, and direct. Now a group of researchers at UQ's Australian Institute for Bioengineering and Nanotechnology (AIBN) bel.....»»
Comparison of four methods on drying efficiency and physicochemical properties of chicken meat
Chicken breast jerky (CBJ) is a popular pet food due to its high crude protein content and long shelf life. In the production of CBJ, the drying process is a crucial step. However, the physicochemical and functional properties of CBJ depend on the dr.....»»
By listening, scientists learn how a protein folds
By converting their data into sounds, scientists discovered how hydrogen bonds contribute to the lightning-fast gyrations that transform a string of amino acids into a functional, folded protein......»»
Scientists introduce DIProT—an interactive deep learning toolkit for efficient protein design
Scientists have developed DIProT, an innovative, user-friendly toolkit for protein design. The toolkit utilizes a non-autoregressive deep generative model to address the protein inverse folding problem, integrating human expertise into the design loo.....»»
Peach perfection: Advanced gene networks reveal fruit traits
A study has tapped into the peach genome, creating large-scale gene co-expression networks (GCNs) that predict gene functions and streamline the peach breeding process. This innovative approach addresses the complex task of identifying genes linked t.....»»
Using hybrid nanotubes to enhance cancer treatment with intracellular protein delivery
The intracellular delivery of proteins is an important technique for unveiling the cellular functions, protein complex structure, and therapeutics. However, conventional delivery methods have several limitations......»»