When mad AIOLOS drags IKAROS down: A novel pathogenic mechanism
Researchers have described a novel primary immunodeficiency due to a mutation in AIOLOS. This acts through a novel pathogenic mechanism termed 'heterodimeric interference', whereby when two different proteins bind together in a heterodimer, the mutan.....»»
Researchers discover new microRNA-regulated pathway to boost iPS cell-derived platelet production
A team of researchers led by Professor Koji Eto (Department of Clinical Application) recently discovered the importance of a microRNA-based regulatory mechanism for enhancing the quality and quantity of platelets generated by iPS cell-derived megakar.....»»
Scientists discover a key quality-control mechanism in DNA replication
When cells in the human body divide, they must first make accurate copies of their DNA. The DNA replication exercise is one of the most important processes in all living organisms and is fraught with risks of mutation, which can lead to cell death or.....»»
Memories of mitosis: Molecular mechanism that detects defects during cell division could aid cancer treatment
Every day, our cells are hard at work multiplying. Cell division is a precise process, but sometimes this process is impaired and diseases like cancer occur. Mitosis is one of the most important phases in the cell cycle. During this phase, a cell's D.....»»
Drama intensifies in Piston Group dispute over minority certification
As a bitter legal fight over the minority status of Piston Group, the country’s largest Black-owned automotive supplier, drags on, a national feud has flared up among the councils in charge of certification......»»
If you"re getting dozens of password reset notifications, you"re being attacked
Apple users are becoming the target of a new wave of phishing attacks called "MFA Bombing" that relies on user impatience, and a bug in Apple's password reset mechanism.An example of the Apple ID password reset notificationPhishing attacks often rely.....»»
Cows in Texas and Kansas test positive for highly pathogenic bird flu
The risk to the public is low, and the milk supply is safe. Enlarge (credit: Getty | Peter Cade) Wild migratory birds likely spread a deadly strain of bird flu to dairy cows in Texas and Kansas, state and federal officia.....»»
Discovery of amino acid unveils how light makes stomata open in plants
Scientists from Nagoya University have discovered a novel regulatory mechanism that controls the opening of stomata in plants, which is crucial for harnessing solar energy through photosynthesis. The team uncovered the role of phosphorylation at the.....»»
Q&A: Clarifying the megathrust earthquake mechanism
There is a 70-80% chance that the Nankai Trough Megathrust Earthquake will occur in the next 30 years. It is predicted to cause more extensive damage than the 2011 Great East Japan Earthquake and fatalities may exceed 320,000......»»
Research challenges "universal mechanism" concept, aiming to understand specific protein interactions
Heat shock proteins (HSPs) are the chaperones of cellular stress response because they help guide the folding and unfolding of other proteins......»»
Scientists elucidate the role of GlyT1 in anti-schizophrenia drugs
Schizophrenia is a highly disabling mental disorder, and numerous studies have shown that the hypofunction of the N-methyl-d-aspartate (NMDA) receptor is one of its pathogenic mechanisms. Glycine transporter 1 (GlyT1), a glycine transporter protein,.....»»
Researchers present "domino effect" sensing mechanism to detect amine approaching picomolar level
Accurate and sensitive detection of amines is crucial in industrial safety, environmental monitoring and clinical diagnosis. Ongoing research and development of sensing materials offer promise for enhancing the sensitivity and selectivity of amine de.....»»
Researchers connect declining atmospheric sulfur dioxide levels to rise in Legionnaires" disease
Declining atmospheric sulfur dioxide levels might be related to the global rise in Legionnaires' disease—a severe form of pneumonia caused by inhaling the pathogenic bacteria Legionella. So reports a new University at Albany study, published today.....»»
New study discovers how altered protein folding drives multicellular evolution
Researchers have discovered a mechanism steering the evolution of multicellular life. They identify how altered protein folding drives multicellular evolution......»»
When plants flower: Scientists ID genes, mechanism in sorghum
Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and Oklahoma State University have identified key genes and the mechanism by which they control flowering in sorghum, an important bioenergy crop. The findings, just p.....»»
New study finds the malaria parasite generates genetic diversity using an evolutionary "copy-paste" tactic
By dissecting the genetic diversity of the most deadly human malaria parasite—Plasmodium falciparum—researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) have identified a mechanism of 'copy-paste' genetics that increases the genetic.....»»
Natural tech for "dimming" genes brings transformative potential to agriculture
Until the 1992 advent of a tomato that could delay softening, the fruit was picked green to withstand shipping. The delayed-softening trait was an example of the gene-silencing technique RNA interference, RNAi, before the underlying mechanism was und.....»»
Unlocking the mechanism of pineapple internal browning
Internal browning (IB) is a significant post-harvest issue in pineapples, impacting fruit quality and leading to substantial losses, yet its mechanism remains poorly understood. Studies have shown that the accumulation of phenolic compounds plays a k.....»»
Study elucidates regulation mechanism for electrocatalytic nitrate reduction
A research team led by Prof. Zhang Haimin from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has conducted a systematic study on the regulation mechanism of heterostructure bimetallic phosphide electrocatalysts to improv.....»»
Molecular mechanism of transmembrane bilirubin transport by human ABCC2 transporter revealed
The metabolic process of bilirubin has been a focus of medical research since the abnormal accumulation of bilirubin has been found to be associated with a variety of diseases. Bilirubin is a substance produced by the breakdown of aging or damaged re.....»»
Avian influenza virus is adapting to spread to marine mammals
The highly pathogenic avian influenza virus H5N1 has adapted to spread between birds and marine mammals, posing an immediate threat to wildlife conservation, according to a study from the University of California, Davis, and the National Institute of.....»»