When mad AIOLOS drags IKAROS down: A novel pathogenic mechanism
Researchers have described a novel primary immunodeficiency due to a mutation in AIOLOS. This acts through a novel pathogenic mechanism termed 'heterodimeric interference', whereby when two different proteins bind together in a heterodimer, the mutan.....»»
Scientists elucidate the role of GlyT1 in anti-schizophrenia drugs
Schizophrenia is a highly disabling mental disorder, and numerous studies have shown that the hypofunction of the N-methyl-d-aspartate (NMDA) receptor is one of its pathogenic mechanisms. Glycine transporter 1 (GlyT1), a glycine transporter protein,.....»»
Researchers present "domino effect" sensing mechanism to detect amine approaching picomolar level
Accurate and sensitive detection of amines is crucial in industrial safety, environmental monitoring and clinical diagnosis. Ongoing research and development of sensing materials offer promise for enhancing the sensitivity and selectivity of amine de.....»»
Researchers connect declining atmospheric sulfur dioxide levels to rise in Legionnaires" disease
Declining atmospheric sulfur dioxide levels might be related to the global rise in Legionnaires' disease—a severe form of pneumonia caused by inhaling the pathogenic bacteria Legionella. So reports a new University at Albany study, published today.....»»
New study discovers how altered protein folding drives multicellular evolution
Researchers have discovered a mechanism steering the evolution of multicellular life. They identify how altered protein folding drives multicellular evolution......»»
When plants flower: Scientists ID genes, mechanism in sorghum
Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and Oklahoma State University have identified key genes and the mechanism by which they control flowering in sorghum, an important bioenergy crop. The findings, just p.....»»
New study finds the malaria parasite generates genetic diversity using an evolutionary "copy-paste" tactic
By dissecting the genetic diversity of the most deadly human malaria parasite—Plasmodium falciparum—researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) have identified a mechanism of 'copy-paste' genetics that increases the genetic.....»»
Natural tech for "dimming" genes brings transformative potential to agriculture
Until the 1992 advent of a tomato that could delay softening, the fruit was picked green to withstand shipping. The delayed-softening trait was an example of the gene-silencing technique RNA interference, RNAi, before the underlying mechanism was und.....»»
Unlocking the mechanism of pineapple internal browning
Internal browning (IB) is a significant post-harvest issue in pineapples, impacting fruit quality and leading to substantial losses, yet its mechanism remains poorly understood. Studies have shown that the accumulation of phenolic compounds plays a k.....»»
Study elucidates regulation mechanism for electrocatalytic nitrate reduction
A research team led by Prof. Zhang Haimin from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has conducted a systematic study on the regulation mechanism of heterostructure bimetallic phosphide electrocatalysts to improv.....»»
Molecular mechanism of transmembrane bilirubin transport by human ABCC2 transporter revealed
The metabolic process of bilirubin has been a focus of medical research since the abnormal accumulation of bilirubin has been found to be associated with a variety of diseases. Bilirubin is a substance produced by the breakdown of aging or damaged re.....»»
Avian influenza virus is adapting to spread to marine mammals
The highly pathogenic avian influenza virus H5N1 has adapted to spread between birds and marine mammals, posing an immediate threat to wildlife conservation, according to a study from the University of California, Davis, and the National Institute of.....»»
Scientists discover why ripe fruit is more susceptible to necrotrophic pathogens than unripe fruit
In a recent study published in Molecular Plant, researchers have elucidated the mechanism underlying the increased susceptibility to necrotrophs during fruit ripening and have developed a rapid strategy to improve tomato fruit resistance to necrotrop.....»»
Study reveals accelerated soil priming under climate warming
A first-of-its-kind study led by researchers at the University of Oklahoma highlights a crucial biosphere feedback mechanism and its effects on releasing soil carbon into the atmosphere......»»
New aging mechanism discovered in nematodes
Even the genes and proteins that have been most closely studied are still far from having given up all their secrets. Like a Swiss Army knife, they have many different, often unknown functions......»»
Cracking the code to a healthier potato chip
In a breakthrough for the snack food industry, a team of scientists led by Michigan State University professors Jiming Jiang and David Douches has discovered a key mechanism behind the darkening and potential health concerns associated with cold-stor.....»»
Newly discovered bacterial defense system functions as self-destruct button
Wageningen researchers have discovered a molecular self-destruct mechanism in a bacterium living on seaweed. With this mechanism the bacteria sacrifice themselves when they are infected, thus protecting their brothers and sisters from infections. By.....»»
Scientists identify genetic mechanism responsible for plant leaf diversity
Plant leaves come in many different shapes, sizes and complexities. Some leaves are large and smooth, while others are smaller and serrated. Some leaves grow in single pieces while others form multiple leaflets. These variations in leaf structure pla.....»»
How a wayside weed builds up explosive force to hurl seeds
Hairy bittercress is one of those plants that hurl their seeds in all directions to spread them effectively. A research team has now discovered that to do this, the plant uses a previously unknown mechanism that makes the seed pods contract and snap.....»»
Discovery of a subset of human short introns that are spliced out by a novel mechanism
The well-known essential pre-mRNA splicing factor U2AF heterodimer (U2AF2–U2AF1) has been identified as mediating early splicing reactions in all introns of different lengths. However, Dr. Kazuhiro Fukumura in the Akila Mayeda lab at Fujita Health.....»»
Nutrients direct intestinal stem cell function and affect aging, finds study
Researchers at the University of Helsinki have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the agi.....»»