The hydroxylation of ASPP2 and other ankyrin repeat domain proteins
Factor Inhibiting Hypoxia Inducible Factor (FIH) has an important role in the response to low oxygen (hypoxia) in animals. FIH adds a hydroxyl (-OH) group onto the master regulator Hypoxia Inducible Factor (HIF), influencing its ability to activate h.....»»
Technique to study how proteins bind to DNA is easily misused: Researchers offer a solution
Researchers at University of California San Diego have published new guidelines that could help scientists significantly improve their results when quantifying the interactions between DNA and proteins. Understanding these interactions is critical to.....»»
Spacewalking is the new domain of the rich as billionaire attempts first private spacewalk
First came space tourism. Now comes an even bigger thrill for the monied masses: spacewalking......»»
Rogue WHOIS server gives researcher superpowers no one should ever have
.mobi top-level-domain managers changed the location of its WHOIS server. No one got the memo. Enlarge (credit: Aurich Lawson | Getty Images) It’s not every day that a security researcher acquires the ability to genera.....»»
With AI, extreme microbe reveals how life"s building blocks adapt to high pressure
An assist from a Google Artificial Intelligence tool has helped scientists discover how the proteins of a heat-loving microbe respond to the crushing conditions of the planet's deepest ocean trenches, offering new insights into how these building blo.....»»
Glitch in protein synthesis could affect tumor growth
During protein synthesis, or translation, genetic information transcribed in the cell's mRNA directs the stringing together of amino acids—the building blocks of proteins. As the translation machinery carouses along the string of nucleotides that m.....»»
Q&A: How single-cell and spatial proteomics reveal proteins" nuanced roles in health and disease
When Steve Carr, senior director of the Proteomics Platform at the Broad Institute of MIT and Harvard, began working in proteomics, the field was able to detect only the most abundant proteins in a given sample. In recent years, increasingly sensitiv.....»»
AI meets biophysics: New approach identifies critical interaction points in cancer-related proteins
Researchers at Auburn University, in collaboration with scientists from the University of Basel and ETH Zurich, have made an advance in the fight against cancer. The team, led by Dr. Rafael Bernardi, Associate Professor of Biophysics in the Departmen.....»»
Algorithm maps protein degradation patterns to improve infection diagnosis and treatment
Peptides are small fragments of proteins, mainly found in the skin and mucous membranes. Some peptides act as a barrier, protecting the body against infections by fighting off microorganisms like bacteria, viruses, and other pathogens, while others p.....»»
RNA editing plays critical role in fruit flies" sense of smell and social interactions
Imagine your DNA as a set of instructions or a recipe book that tells your body how to make everything it needs to function, from proteins to cells. Every time the body needs to build something, it reads these instructions. But sometimes, the body ca.....»»
Recreated 1870s railway photos reveal profound changes to Kansas and Colorado plains
A new book chronicling transformation on the plains of Kansas and western Colorado uses repeat photography—contemporary re-creations of 1870s photos—to reveal startling changes to the landscape......»»
Cells use alternative splicing to regulate gene expression, research suggests
Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism increases the diversity of proteins that can be generat.....»»
Protein mutant stability can be inferred from AI-predicted structures
Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI......»»
Study finds flexibility and helical twists of actin filaments regulate actin-binding proteins
Researchers at Kanazawa University have published an article in eLife deciphering the actin structure-dependent preferential cooperative binding of cofilin......»»
Simulation model shows ribosome tunnel"s impact on protein structures
Researchers at University of Tsukuba have developed a new model that simulates the internal environment of a ribosome—the cellular site of protein synthesis. Using computer simulations, they have analyzed the structures of various proteins within t.....»»
Dual protein analysis approach provides potential way to slow cancer growth
Fighting cancer effectively often involves stopping cancer cells from multiplying, which requires understanding proteins that the cells rely on to survive. Protein profiling plays a critical role in this process by helping researchers identify protei.....»»
Proof-of-concept study demonstrates mid-infrared computational temporal ghost imaging
Ghost imaging in the time domain allows for reconstructing fast temporal objects using a slow photodetector. The technique involves correlating random or pre-programmed probing temporal intensity patterns with the integrated signal measured after mod.....»»
3D shapes of viral proteins point to previously unknown roles
Viruses are tricky to keep up with. They evolve quickly and regularly develop new proteins that help them infect their hosts. These rapid shifts mean that researchers are still trying to understand a multitude of viral proteins and precisely how they.....»»
Tomato ripening study highlights cell wall component interactions
Tomato fruit ripening involves intricate biochemical and structural changes, particularly within the cell wall, which are vital for the fruit's final texture and quality. These changes include modifications in polysaccharides and proteins, but the sp.....»»
Lyft Pet Rides will prevent repeat of Tux the Missing Cat drama
Today is National Dog Day, a fitting date for the launch of Lyft Pet Rides, a feature intended to match those transporting pets with drivers happy to accommodate them … more….....»»
Rebrand, regroup, ransomware, repeat
Changes witnessed over the last few years have led to larger ransomware groups breaking into smaller units, posing more considerable challenges for law enforcement. Ransomware actors are evading arrest more easily and adapting methods with innovative.....»»