The hydroxylation of ASPP2 and other ankyrin repeat domain proteins
Factor Inhibiting Hypoxia Inducible Factor (FIH) has an important role in the response to low oxygen (hypoxia) in animals. FIH adds a hydroxyl (-OH) group onto the master regulator Hypoxia Inducible Factor (HIF), influencing its ability to activate h.....»»
Planning a drug"s route in the body with synthetic chemistry
Researchers at the RIKEN Cluster for Pioneering Research (CPR) have developed technology that can alter, within the body, the recognized identity of proteins......»»
Research provides new insights into role of mechanical forces in gene expression
The genome inside each of our cells is modeled by tension and torsion—due in part to the activity of proteins that compact, loop, wrap and untwist DNA—but scientists know little about how those forces affect the transcription of genes......»»
Seeing double: Designing drugs that target "twin" cancer proteins
Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites......»»
Active Directory compromise: Cybersecurity agencies provide guidance
Active Directory (AD), Microsoft’s on-premises directory service for Windows domain networks, is so widely used for enterprise identity and access management that compromising it has become almost a standard step in cyber intrusions. “Act.....»»
Scientists identify structural basis of stitched-together protein complexes that recycle most proteins in cells
Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell's recycling process for obsolete and misshapen proteins—known as proteasomes—are formed......»»
Active Directory compromise: Cybersecurity agencies provde guidance
Active Directory (AD), Microsoft’s on-premises directory service for Windows domain networks, is so widely used for enterprise identity and access management that compromising it has become almost a standard step in cyber intrusions. “Act.....»»
AI trained on evolution"s playbook develops proteins that spur drug and scientific discovery
A new artificial intelligence model developed by researchers at The University of Texas at Austin paves the way for more effective and less toxic treatments and new preventive strategies in medicine. The AI model informs the design of protein-based t.....»»
Biologists sequence proteins by pulling them through nanopores
A team of chemical biologists at the University of Washington, working with colleagues at Oxford Nanopore Technologies, has developed a protein sequencing process that involves pulling proteins through nanopores in a lipid membrane. Their paper is pu.....»»
Researcher develops low-sugar ice cream with smooth texture
Wageningen researcher Qi Wang has developed a new variant of low-sugar ice cream that mimics the texture and melting properties of traditional ice cream. By replacing half of the sugar with broken-down proteins or the sweetener xylitol, she succeeded.....»»
Strategies for maximizing recombinant protein production in tobacco plants
Plant molecular farming (PMF) is a modern, sophisticated technology that utilizes plants' biosynthetic machinery to synthesize a plethora of recombinant proteins, including industrial and therapeutic enzymes. It has several advantages over traditiona.....»»
Naked mole-rat found to have lost infection-resistant proteins
Scientists have found that the naked mole-rat—an underground rodent that lives up to 40 years—has lost a number of CD1 functional genes. The CD1 gene family in mammals is responsible for protein synthesis that protects the body against infectious.....»»
Chemists discover new ways in which single-celled organisms organize their DNA
It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden Ph.D. candidate Samuel Schwab has found that the histones in these organisms are much more diverse.....»»
From chaos to order: Proteins can re-structure themselves to create important substances
The protein "MIPS" changes its internal structure when it becomes active. Its disordered active center becomes a defined structure with special functions. The protein plays a key role in the production of inositol, which is also known as vitamin B8,.....»»
New method developed to relocate misplaced proteins in cells
Cells are highly controlled spaces that rely on every protein being in the right place. Many diseases, including cancers and neurodegenerative disorders, are associated with misplaced proteins. In some cancers, for instance, a protein that normally s.....»»
Google calls for halting use of WHOIS for TLS domain verifications
WHOIS data is unreliable. So why is it used in TLS certificate applications? Enlarge (credit: Getty Images) Certificate authorities and browser makers are planning to end the use of WHOIS data verifying domain ownership.....»»
New material with wavy layers of atoms exhibits unusual superconducting properties
MIT physicists and colleagues have created a new material with unusual superconducting and metallic properties, thanks to wavy layers of atoms only billionths of a meter thick that repeat themselves over and over to create a macroscopic sample that c.....»»
Light-induced immunoassay can selectively detect coronavirus spike proteins in five minutes
Like moths to a flame, microbes can also be moved by light. Using this knowledge, researchers from Osaka Metropolitan University's Research Institute for Light-induced Acceleration System (RILACS) have demonstrated a method to detect the presence of.....»»
Team discovers naturally occurring DNA-protein hybrids
Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine the homing powers of DNA with the broad functional repertoire of proteins—without having to synthesize them one by one, res.....»»
Symmetry model sheds light on the chemistry surrounding peptide helices
Helices are structures found naturally in many important molecules, such as proteins. These helices possess a twist that depends on the arrangement of their basic components. By understanding how a helix is formed, we can gain deeper insights into ho.....»»
Windows is still making changes to prevent another CrowdStrike-type disaster
After what happened with CrowdStrike, Microsoft wants to ensure that the incident doesn't repeat itself by making some important changes to its security......»»