SPNS2 found to be directly exporting S1P for signaling, can be inhibited
When an enemy invades, defenders are ferried to the site to neutralize the marauders. In the human body, a protein carrier called SPNS2 transports S1P molecules from endothelial cells to rally immune cell response in infected organs and tissues......»»
Study demonstrate improved root growth in radio-cesium contaminated soil
Researchers at the RIKEN Center for Sustainable Resource Science (CSRS) have identified a way for plants to gain resistance to cesium, a radioactive toxin that can be found in contaminated soil. After manipulating a specific biological signaling path.....»»
A systematic review of three key sugar metabolism proteins: HXK, SnRK1 and TOR
Sugar signaling is one of the most important regulatory signals for plant growth and development, and its metabolic network contains many regulatory factors. Sugar signaling molecules regulate cellular activities and organismal development by interac.....»»
Molecular mechanism of CmoDREB2A and CmoNAC1 in pumpkin regulating the salt tolerance of grafted cucumber revealed
In February 2024, a research article titled "Pumpkin CmoDREB2A enhances salt tolerance of grafted cucumber through interaction with CmoNAC1 to regulate H2O2 and ABA signaling and K+/Na+ homeostasis" was published by Professor Zhilong Bie's team from.....»»
Microsoft’s Phi-3 shows the surprising power of small, locally run AI language models
Microsoft’s 3.8B parameter Phi-3 may rival GPT-3.5, signaling a new era of “small language models." Enlarge (credit: Getty Images) On Tuesday, Microsoft announced a new, freely available lightweight AI language model.....»»
The role of TOR signaling in enhancing graft success and crop vigor
A research team has delved into the Target of Rapamycin (TOR) signaling pathway in plant grafting, emphasizing its role in regulating seedling vigor, graft junction healing, and shoot-to-root communications. Exploring TOR's involvement offers a promi.....»»
New signaling pathway decoded in the decomposition of damaged lysosomes
Lysosomes are surrounded by a lipid bilayer that separates the acidic environment and the digestive enzymes of the organelle from the cytoplasm. Damage to this layer—lysosomal membrane permeabilization, or LMP for short—can trigger inflammation a.....»»
Security pros are cautiously optimistic about AI
55% of organizations plan to adopt GenAI solutions within this year, signaling a substantial surge in GenAI integration, according to a Cloud Security Alliance and Google Cloud survey. The survey received 2,486 responses from IT and security professi.....»»
New study paves the way for precision drugs to treat blood cancers
The Janus kinase 2 (JAK2) protein mediates signaling from several cytokine receptors in the regulation of hematopoiesis and immune responses. Somatic mutations in human JAK2 lead to constitutive activation and cytokine-independent signaling and under.....»»
Apple’s new Beats Solo 4 headphones hit the FCC ahead of launch
In February, images of unreleased Beats Solo 4 headphones were revealed thanks to the iOS 17.4 beta. Now, the Beats Solo 4 have popped up in the FCC’s database, signaling that a launch is imminent. They’ll mark the first update to the Beats Solo.....»»
Gene editing technology reveals molecular mechanisms governing diatom population density signals
The intricate dynamics of diatom blooms, influenced by a myriad of external factors and internal signals, continue to fascinate scientists. After recognizing the potential role of density perception and intracellular signaling in dictating these phen.....»»
Scientists identify novel lysosome fission factor
Lysosomes are centers for degradation, recycling, and signaling of cellular materials that are crucial for maintaining cellular homeostasis, development, and aging. To meet various physiological demands, lysosomes continuously remodel their shape and.....»»
Enhancing apple adventitious shoot regeneration: The role of MdAIL5 in hormonal signaling and gene activation
Plants exhibit a remarkable capacity for self-repair and regeneration, a process crucial for adapting to environmental changes and underpinned by cellular totipotency or pluripotency. Apple is one of the model plants for the study of perennial woody.....»»
Secure email gateways struggle to keep pace with sophisticated phishing campaigns
In 2023, malicious email threats bypassing secure email gateways (SEGs) increased by more than 100%, according to Cofense. In just two years, Cofense identified over 1.5 million malicious emails bypassing their customers’ SEGs, signaling a 37% incr.....»»
Study finds new inhalable therapy is a big step forward in lung cancer research
Lung cancer is one of the most common cancers and has one of the lowest survival rates in the world. Cytokines, which are small signaling proteins, such as interleukin-12 (IL-12), have demonstrated considerable potential as robust tumor suppressors......»»
SPNS2 found to be directly exporting S1P for signaling, can be inhibited
When an enemy invades, defenders are ferried to the site to neutralize the marauders. In the human body, a protein carrier called SPNS2 transports S1P molecules from endothelial cells to rally immune cell response in infected organs and tissues......»»
Key innovation in photonic components could transform supercomputing technology
Programmable photonic integrated circuits (PPICs) process light waves for computation, sensing, and signaling in ways that can be programmed to suit diverse requirements. Researchers at Daegu Gyeongbuk Institute of Science and Technology (DGIST), in.....»»
Transcription factor"s key role in grafted cucumbers reveals salt tolerance in crops
Soil salinity, impacting about 1 billion square hectometers worldwide, significantly hinders crop growth. Plants counteract this through signaling pathways involving molecules such as H2O2 and ABA. NAC transcription factors, which are unique to plant.....»»
Endosomal stress, a newly defined organelle stress, induces inflammation via ubiquitin signaling
The endosome is an essential organelle located at the center of membrane traffic and mainly sorts plasma membrane proteins internalized by endocytosis in cooperation with ubiquitination, especially lysine-63-linked polyubiquitin chains (K63 ubiquitin.....»»
Deciphering crosstalk between bFGF and integrin signaling in maintaining properties of hiPSCs
A research team led by Junior Associate Professor Masato Nakagawa (Department of Life Science Frontiers) investigated the effects of basic fibroblast growth factor (bFGF) and its interactions with fibroblast growth factor receptors (FGFRs) and integr.....»»
Engineers invent octopus-inspired technology that can deceive and signal
With a split-second muscle contraction, the greater blue-ringed octopus can change the size and color of the namesake patterns on its skin for purposes of deception, camouflage and signaling. Researchers at the University of California, Irvine have d.....»»