SARS-CoV-2: Neutralization of BA.1 and BA.2 by therapeutic monoclonal antibodies
Scientists studied the sensitivity of Omicron BA.1 and BA.2 to nine monoclonal antibodies, some of which are used in pre-exposure prophylaxis in immunocompromised individuals. The scientists showed a loss of neutralizing activity against BA.1 and BA......»»
Engineered E. coli delivers therapeutic nanobodies to the gut
Humans are colonized with thousands of bacterial strains. Researchers are now focused on genetically modifying such bacteria to enhance their intrinsic therapeutic properties......»»
Discovery of drug candidate that neutralizes SARS-CoV-2 could reduce length of infection upon exposure
The discovery of a small molecule in the research lab of Bradley McConnell, professor of pharmacology at the University of Houston College of Pharmacy, may well be the genesis of new medication which could shorten the course of the SARS-CoV-2 virus......»»
Important step towards accurate use of stem cell–based disease models
Induced pluripotent stem cells offer great therapeutic potential and are a valuable tool for understanding how different diseases develop. New research shows that such stem cell lines should be regularly screened for genetic mutations to ensure the a.....»»
Study: SARS-CoV-2 can alter genome structure of our cells
People infected with SARS-CoV-2, the virus that causes COVID-19, may experience genome structure changes that not only may explain our immunological symptoms after infection, but also potentially link to long COVID, according to a new study by resear.....»»
Genetic data links SARS-CoV-2 to raccoon dogs in China market, scientists say
"These data could have—and should have—been shared three years ago." Enlarge / A raccoon dog at the Chapultpec Zoo in Mexico City on August 6, 2015. (credit: Getty | ALFREDO ESTRELLA/) Newly obtained genetic data fr.....»»
Antibody fragment-nanoparticle therapeutic eradicates gastric cancer, shows research
A novel cancer therapeutic, combining antibody fragments with molecularly engineered nanoparticles, permanently eradicated gastric cancer in treated mice, a multi-institutional team of researchers found......»»
Innovative approach opens the door to COVID nanobody therapies
COVID is not yet under control. Despite a bevy of vaccines, monoclonal antibodies, and antivirals, the virus continues to mutate and elude us. One solution that scientists have been exploring since the early days of the pandemic may come in the form.....»»
Enzyme ATE1 plays role in cellular stress response, opening door to new therapeutic targets
A new paper in Nature Communications illuminates how a previously poorly understood enzyme works in the cell. Many diseases are tied to chronic cellular stress, and UMBC's Aaron T. Smith and colleagues discovered that this enzyme plays an important r.....»»
No One Knows if You Need Another Covid Booster
It’s cellular immunity, not antibodies, that probably protects against the coronavirus’s worst effects—and scientists haven’t worked out how long it lasts......»»
Cyborg technology analyzes the functional maturation of stem-cell derived heart tissue
Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first pre.....»»
Study finds silicon, gold and copper among new weapons against COVID-19
New Curtin research has found the spike proteins of SARS-CoV-2, a strain of coronaviruses that caused the COVID-19 pandemic, become trapped when they come into contact with silicon, gold and copper, and that electric fields can be used to destroy the.....»»
DNA repair discovery could improve biotechnology
A team of researchers from Michigan State University's College of Veterinary Medicine has made a discovery that may have implications for therapeutic gene editing strategies, cancer diagnostics and therapies and other advancements in biotechnology......»»
New method for the detection of RNA viruses such as SARS-CoV-2
Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) and the Aragon Nanoscience and Materials Institute of Aragon (INMA)—a joint insti.....»»
81% of international flights into NYC had SARS-CoV-2 in waste, small trial finds
The study demonstrated feasibility as COVID surveillance nose-dives worldwide. Enlarge / Passengers on an Air France flight on April 20, 2021. (credit: Getty | Francois LOCHON) In a small trial, aircraft wastewater prov.....»»
Multiple mutations may help omicron variant escape antibodies
An array of different mutations or combinations of mutations may help the omicron variant of SARS-CoV-2 escape immune responses or therapeutic antibodies, according to a study published today in eLife......»»
Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature
In vivo small animal fluorescence imaging is widely used in oncology, drugs, antibodies, nanomaterials, inflammation, immune diseases, gene therapy, apoptosis, and other research fields because of its advantages such as in vivo real-time imaging obse.....»»
Study highlights therapeutic importance of Ganoderma lucidum
Researchers led by Prof. Huang Qing from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences reported for the first time an update and a comprehensive summary on the immunomodulatory therapies and nutritional significance of G.....»»
Researchers study first stem cells from a bat species known to harbor SARS-CoV-2
Researchers from the Icahn School of Medicine at Mount Sinai have generated the first induced pluripotent stem cells (iPSCs) from bats, gaining valuable insights into the close relationship between bats and viruses. This research opens the door to st.....»»
Study identifies novel host protease determinants for SARS-CoV-2 infection
Researchers from Department of Microbiology, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has identified novel host protease determinants that facilitate the infection of SARS-CoV-2, including the omicro.....»»
Weaponizing part of the SARS-CoV-2 spike protein against itself to prevent infection
The virus that causes COVID-19, called SARS-CoV-2, uses its spike protein in order to stick to and infect our cells. The final step for the virus to enter our cells is for part of its spike protein to act like a twist tie, forcing the host cell's out.....»»