Regulation of protein homeostasis by cardiac glycosides
The unfolded protein response (UPR) is a pivotal mechanism to mitigate protein homeostasis through transcriptional or translational control. On the other hand, since dysregulation of UPR has been associated with various human diseases, the compounds.....»»
Targeting "undruggable" diseases: Researchers reveal new levels of detail in targeted protein degradation
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, including cancers and ne.....»»
Oxidative stress: How protein recycling protects against cell death
Researchers at LMU University Hospital have discovered a new molecular switch that protects against cell death......»»
Scientists discover how innate immunity envelops bacteria
The protein GBP1 is a vital component of our body's natural defense against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat, but how the substance manages to do this has remained unknown until now......»»
DORA regulation’s nuts and bolts
The frequency, sophistication, and impact of cyber-attacks on financial institutions have been rising. Given the economic system’s interconnected nature, disruptions in one institution can have cascading effects on the broader financial market,.....»»
AI-driven approach challenges traditional views on protein structure
In a recently published article in Nature Communications,, a team offers an AI-driven approach to explore structural similarities and relationships across the protein universe. The team includes members from the University of Virginia—including Phi.....»»
Detailed images of key protein complexes provide new insights into bacterial photosynthesis
Researchers at the University of Liverpool and collaborators have arrived at a new understanding of bacterial photosynthesis. Using novel techniques, investigators have unveiled intricate detailed images of the key photosynthetic protein complexes of.....»»
Protein structure and design software gets the Chemistry Nobel
One academic and two people from DeepMind take home the Nobel. On Wednesday, the Nobel Committee announced that it had awarded the Nobel Prize in chemistry to researchers who pion.....»»
Study reveals relationship between nitrogen-cycling microbial communities and nitrogen removal
Excess nitrogen (N) input to the inland water bodies and marine ecosystem has contributed to a cascade of environmental issues, so N removal pathways are critical in aquatic and terrestrial ecosystems for maintaining homeostasis. Associated functiona.....»»
Nanopore technique shows transport mechanism of chaperone proteins at the single-molecule level
Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control protein quality......»»
Paper-based sensor offers rapid cardiac diagnostics in 15 minutes
In a significant advancement for point-of-care medical diagnostics, a team of researchers from UCLA has introduced a deep learning-enhanced, paper-based vertical flow assay (VFA) capable of detecting cardiac troponin I (cTnI) with high sensitivity. T.....»»
Cellular agriculture research manages to culture pork fat tissue on rye protein scaffolds
National University of Singapore (NUS) food scientists have developed a simple and scalable method for culturing pork fat tissue using protein scaffolds made from secalin, a protein extracted from rye......»»
Scientists find plant-like behavior in human cells
A team of scientists from Monash University has solved the structure of a protein known as "LYCHOS," which can detect and regulate cell growth by sensing cholesterol levels in the body......»»
Ancient protein structure may have enabled early molecular evolution and diversification
In a finding that offers fresh insights into the early evolution of life on Earth, two RIKEN biologists have conducted lab experiments that have revealed a previously unknown protein fold, which is completely absent in modern proteins......»»
As Wildfires Rage, California’s Insurance Market Is in Crisis
Providers are offering fewer and fewer policies because of costlier climate-fueled fires, homeowners moving into riskier areas, and outdated regulation of the insurance industry......»»
Filament structure found to activate and regulate CRISPR-Cas "protein scissors"
CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, al.....»»
Protein involved in the early stages of age-related macular degeneration offers hope for prevention
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the United States. Despite existing treatments, the underlying causes of this disease and effective therapies remain elusive. Research published in the journal D.....»»
Researchers determine how a protein contributes to human immune defense against RNA viruses
An international research team led by Prof. Dr. Janosch Hennig from the University of Bayreuth has discovered how the TRIM25 protein contributes to defense against RNA viruses whose genetic material is contained as ribonucleic acid (RNA)......»»
3D structure of key protein could advance development of hormone-free male contraceptive pill
Melbourne-based scientists behind the development of a hormone-free, reversible male contraceptive pill have, for the first time, solved the molecular structure of the discovery program's primary therapeutic target, significantly increasing the chanc.....»»
California governor vetoes expansive AI safety bill
Despite increasing calls for regulation, California Governor Gavin Newsom has vetoed the far reaching AI safety bill, SB 1047.....»»
Major AI bill vetoed by California governor, despite increased calls for regulation
California is home to many of the country’s largest AI innovators, including Apple. Today, they’re all breathing a sigh of relief. Governor Gavin Newsom has vetoed a major AI regulatory bill that came to his desk, while nonetheless highlighting t.....»»