Protein disguise could be new target for cancer immunotherapy
Researchers have identified a protein that helps tumors evade the immune system and, in certain types of cancers, is linked to a poorer chance of survival. The protein could become a target for future cancer treatments......»»
Ancient protein structure may have enabled early molecular evolution and diversification
In a finding that offers fresh insights into the early evolution of life on Earth, two RIKEN biologists have conducted lab experiments that have revealed a previously unknown protein fold, which is completely absent in modern proteins......»»
Study: Wildfires will make the land absorb much less carbon, even if warming is kept below 1.5°C
One of the aims of the Paris Agreement was to "pursue efforts" to keep global warming below 1.5°C, but even this ambitious target would not stop the land's ability to absorb carbon weakening as wildfires become fiercer and more frequent, according t.....»»
Private US companies targeted by Stonefly APT
Undeterred by the indictment issued against one of its alleged members, North Korean APT group Stonefly (aka APT45) continues to target companies in the US, Symantec threat analysts warned. About Stonefly Also known as Andariel and OnyxFleet, Stonefl.....»»
Filament structure found to activate and regulate CRISPR-Cas "protein scissors"
CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, al.....»»
Protein involved in the early stages of age-related macular degeneration offers hope for prevention
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the United States. Despite existing treatments, the underlying causes of this disease and effective therapies remain elusive. Research published in the journal D.....»»
Researchers determine how a protein contributes to human immune defense against RNA viruses
An international research team led by Prof. Dr. Janosch Hennig from the University of Bayreuth has discovered how the TRIM25 protein contributes to defense against RNA viruses whose genetic material is contained as ribonucleic acid (RNA)......»»
AI model detects impervious surfaces in aerial images
In accordance with the German Sustainability Strategy, new impervious surfaces are to be limited to less than 30 hectares per day nationwide. In order to verify whether this target is met, it must be possible to monitor soil sealing at regular interv.....»»
Seeing double: Designing drugs that target "twin" cancer proteins
Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites......»»
3D structure of key protein could advance development of hormone-free male contraceptive pill
Melbourne-based scientists behind the development of a hormone-free, reversible male contraceptive pill have, for the first time, solved the molecular structure of the discovery program's primary therapeutic target, significantly increasing the chanc.....»»
Utah mom with terminal cancer plans her own funeral after three month diagnosis
Utah mom with terminal cancer plans her own funeral after three month diagnosis.....»»
‘I’m an Oncologist—This Is the Afternoon Snack I Eat Almost Every Day for Cancer Prevention’
‘I’m an Oncologist—This Is the Afternoon Snack I Eat Almost Every Day for Cancer Prevention’.....»»
Cancer spread to Jimmy Carter"s brain 9 years ago. Here"s how he"s lived so long.
Cancer spread to Jimmy Carter"s brain 9 years ago. Here"s how he"s lived so long......»»
DNA nanotechnology unravels complex protein interactions to inform cancer diagnostics
A team of researchers from NUS Institute for Health Innovation & Technology (iHealthtech), led by Associate Professor Shao Huilin and Associate Professor Brian Lim, has developed a first-of-its-kind technology to map out diverse protein interactions.....»»
Protein study reveals how the tiny shrew achieves a resting heart rate of 1,020 beats per minute
The shrew's resting heart rate can reach up to 17 beats per second, equivalent to about 1,020 beats per minute. In comparison, the average human resting heart rate is around 60 to 100 beats per minute, making the shrew's resting heart rate approximat.....»»
SCCMSecrets: Open-source SCCM policies exploitation tool
SCCMSecrets is an open-source tool that exploits SCCM policies, offering more than just NAA credential extraction. SCCM policies are a key target for attackers in Active Directory environments, as they can expose sensitive technical information, incl.....»»
Trimer complex TaNF-Y balances grain yield and quality in wheat: Study
Breeding efforts have focused intensively on improving grain yield and quality in wheat (Triticum aestivum L.). Content and composition of grain starch and seed storage protein (SSP) are two critical factors that determine grain yield and quality. St.....»»
How a protein keeps gene clusters quiet in the cell nucleolus
In a discovery that sheds light on the complex mechanisms of gene regulation, scientists at EPFL have uncovered a critical role for the protein ZNF274 in keeping certain gene clusters turned off by anchoring them to the cell nucleolus. The study is p.....»»
Scientists identify structural basis of stitched-together protein complexes that recycle most proteins in cells
Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell's recycling process for obsolete and misshapen proteins—known as proteasomes—are formed......»»
Shedding light on a decades-old protein sorting mystery
Christian de Caestecker, a Ph.D. student in the lab of Ian Macara, Louise B. McGavock Professor and chair of the Department of Cell and Developmental Biology, has proposed and validated a mechanism that addresses a decades-old mystery surrounding epi.....»»
AI trained on evolution"s playbook develops proteins that spur drug and scientific discovery
A new artificial intelligence model developed by researchers at The University of Texas at Austin paves the way for more effective and less toxic treatments and new preventive strategies in medicine. The AI model informs the design of protein-based t.....»»