New enzyme could mean better drugs
Just as a choreographer's notation tells a dancer to strike a particular pose, an enzyme newly discovered by Rice University scientists is able to tell specific molecules precisely how to arrange themselves, down to the angle of single hydrogen bonds.....»»
Breakthrough in plant disease: New enzyme could lead to anti-bacterial pesticides
Plant diseases pose significant challenges to agricultural productivity, presenting formidable hurdles that require urgent attention. Left unchecked, these diseases can spread rapidly, inflicting widespread damage on crops and leading to reduced yiel.....»»
Electrical impedance tomography plus extracellular voltage activation technique simplifies drug screening
When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical. Blocking hERG channels can disrupt a normal hear.....»»
Weight loss drugs like Ozempic can also help people stop smoking
Drugs containing semaglutide, like Ozempic and Wegovy, are intended to help people with diabetes lower their blood glucose levels while also reducing the risk of … The post Weight loss drugs like Ozempic can also help people stop smoking appear.....»»
"Russian doll" packaging could boost drug delivery
New technology, which is in the early stages of development, has the potential to significantly enhance the effectiveness and reduce the side effects of drugs and vaccines......»»
People are overdosing on off-brand weight-loss drugs, FDA warns
Bad math and unclear directions are behind overdoses of up to 20 times the normal amount. Enlarge / Wegovy is an injectable prescription weight-loss medicine that has helped people with obesity. (credit: Getty | Michael Siluk).....»»
The Race for the Next Ozempic
The next wave of obesity drugs could help people lose even more weight—and make some pharma companies a fortune......»»
Scientists hijack natural delivery system to send engineered proteins to target cells
Each cell in the body has its own unique delivery system that scientists are working on harnessing to move revolutionary biological drugs—molecules like proteins, RNA and combinations of the two—to specific diseased parts of the body......»»
Nature-inspired novel catalyst paves the way for efficient hydrocarbon decomposition
A research team affiliated with UNIST has developed a novel catalyst that mimics the ability of a natural enzyme to break down harmful hydrocarbons, paving the way for a more environmentally friendly and energy-efficient approach to reducing pollutio.....»»
Discovery of daphnane diterpenoids in Daphne pedunculata could lead to new HIV drugs
A research group led by Professor Wei Li of the Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, in collaboration with Shenyang Pharmaceutical University in China and Duke University Medical Center in the United State.....»»
Researchers advance understanding of a key celiac enzyme
Celiac disease affects around one in a hundred people worldwide, and those that have the autoimmune disorder have no choice but to stick to a gluten-free diet forever—at the moment, doctors have no other way to treat the illness......»»
Discovery of a tRNA modification enzyme that also acts on nucleosides
The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis.....»»
Scientists replicate enzyme that captures carbon
Scientists from King's College London have recreated the active site of Acetyl-CoA Synthase, an enzyme involved in capturing carbon from the atmosphere. The research, carried out in collaboration with Imperial College London, advances our understandi.....»»
De-risking drug discovery with predictive AI
Developing a new drug can take years of research and cost millions of dollars. Still, more than 90% of drug candidates fail in clinical trials, with even more that never make it to the clinical stage. Many drugs fail because they simply aren't safe......»»
Enzyme-powered "snot bots" help deliver drugs in sticky situations
Snot might not be the first place you'd expect nanobots to be swimming around. But this slimy secretion exists in more places than just your nose and piles of dirty tissues—it also lines and helps protect the lungs, stomach, intestines and eyes. An.....»»
Research team develops method to design safer opioids
Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose. In a study appearing in ACS Central Science, researchers hav.....»»
Harnessing big data helps scientists hone in on new antimicrobials
Researchers have developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets, providing clues for discovering alternatives to traditional antibiotics......»»
Researchers develop library for RNA-based therapeutic approaches with polymer nanoparticles
RNA therapy with polymer nanoparticles is considered a promising approach for the treatment of various illnesses. It involves the use of polymers as "nanocarriers" to transport RNA drugs precisely to the correct target cells. Manufacturing such polym.....»»
Research team develops light-activated compounds to treat neuropathic pain
Light can be used to activate drugs in specific parts of the body through photopharmacology. This innovative approach involves modifying the chemical structure of a drug by adding a light-activated molecular switch, such as azobenzene. This allows th.....»»
It’s Shockingly Easy to Buy Off-Brand Ozempic Online, Even If You Don’t Need It
Weight-loss drugs like Ozempic are in shortage, and telehealth startups are selling “compounded” versions. A WIRED investigation looks at how easy it is to order these meds online......»»
A comprehensive derivative synthesis method for development of new antimicrobial drugs
Efforts to combat the increasing threat of drug-resistant bacteria are being assisted by a new approach for streamlining the search for antimicrobial drug candidates, pioneered by researchers at Hokkaido University, led by Assistant Professor Kazuki.....»»