mRNA delivered by extracellular vesicles induces immunotherapy response in glioblastoma
A team of researchers at The University of Texas MD Anderson Cancer Center has developed a new method for using extracellular vesicles to enhance responses to immunotherapy in glioblastoma, potentially opening the door for wider use of engineered mes.....»»
The right to be wrong: How context or human rationality may influence our decisions
Conventionally, decision-making is portrayed as a rational process: individuals calculate potential risks and aim to maximize benefits. Yet, our brains do not always endorse rational action, particularly when an immediate response is required. Someti.....»»
Cells use alternative splicing to regulate gene expression, research suggests
Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism increases the diversity of proteins that can be generat.....»»
Broken Sonos app roadmap now available on Trello for all to see
Whether you use Sonos or not, there’s a good chance you’ve heard about the broken Sonos app and its endless redesign troubles. In response to user frustration about the new app’s shortcomings, Sonos has launched a public roadmap for its future......»»
Midnight Blizzard delivered iOS, Chrome exploits via compromised government websites
Suspected Russian hackers have been hitting iPhone and Android users visiting government websites with exploits first leveraged by commercial surveillance vendors, Google TAG researchers shared. The watering hole campaigns Between November 2023 and J.....»»
Using metal ion-linked nanostructures to improve immune response and boost breast tumor treatment
Immune checkpoint blockade (ICB) is one of the primary methods of tumor immunotherapy. However, clinical data have shown that only a portion of patients respond to ICB treatment. Since the tumor's immune-suppressive environment plays a crucial role i.....»»
Red flag laws may reduce the growing burden of firearm homicides
A recent study from researchers at Columbia University Mailman School of Public Health has found that Florida's red flag gun law, which was enacted in response to the 2018 Parkland mass shooting, was associated with an 11% reduction in firearm homici.....»»
Fortinet introduces sovereign SASE and GenAI capabilities
Fortinet announced the addition of sovereign SASE and GenAI capabilities to its unified SASE solution. Fortinet Unified SASE provides complete integration between Fortinet’s Secure SD-WAN solution and cloud-delivered security service edge (SSE) und.....»»
This 1ms gaming monitor is on sale for $250 at Best Buy
The 27-inch LG UltraGear QHD gaming monitor with a 1ms response time is an excellent entry-level option for gamers, especially as it's $150 off from Best Buy......»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
A hybrid arrowhead against immune disorders: Bacterially derived natural product inhibits cellular immune response
The so-called immunoproteasome is essential for the cellular immune response. In autoimmune diseases, however, it is overactive. Until now, it has not been possible to selectively inhibit the immunoproteasome without disrupting other cellular mechani.....»»
On wildfires, experts say the West needs to rethink its response
Wildfires and the pain they cause to people, property and the planet are here to stay. And if Western management practices don't change to anticipate more and more record fire years, that pain may spread and worsen......»»
The truth about Tasers: What UK statistics and research tell us
Prime Minister Keir Starmer recently urged the police to take "all necessary action" in response to unrest across cities and towns in England and Northern Ireland......»»
The Next Frontier for mRNA Could Be Healing Damaged Organs
Researchers are testing the use of mRNA to get damaged livers to repair themselves, in a move that could one day lessen the need for organ transplants......»»
FDA green-lights fall COVID-19 boosters
Updated mRNA vaccines from Pfizer and Moderna are ready to roll. Enlarge (credit: Getty Images) As the COVID-19 case count continues to tick upward, the US Food and Drug Administration has approved an updated vaccine for.....»»
Novel silica nonwoven fabric scaffold enhances understanding of cell-to-cell interactions
Communication and coordination among different cells are fundamental aspects that regulate many functions in our body. This process, known as paracrine signaling, involves the release of signaling molecules by a cell into its extracellular matrix (EC.....»»
Apple"s App Store vice president is the first departure in regulatory shake-up
Matt Fischer, Apple's App Store vice president, will depart the company in the coming months as the tech giant prepares to restructure as a response to global regulations. Apple's vice president of App Store departing company in October Fischer has b.....»»
Research team designs AI approach to drought zoning in Canada
A recent study by the University of Ottawa and Laval University shows that climate change may cause many areas in Canada to experience significant droughts by the end of the century. In response, the researchers have introduced an advanced AI-based m.....»»
App Store VP departing Apple amid broader restructuring
Apple’s App Store vice president is leaving the company in October, according to a new report from Bloomberg. The structure of the App Store team is also being split into two teams, a change implemented by Phil Schiller in response to the ever-.....»»
Apple App Store vice president of the App Store is the first departure in regulatory shake-up
Matt Fischer, Apple's App Store vice president, will depart the company in the coming months as the tech giant prepares to restructure as a response to global regulations. Apple's vice president of App Store departing company in October Fischer has b.....»»
Lipid nanoparticle mRNA therapy improves survival in mouse models of maple syrup urine disease
Researchers from the University of Pennsylvania, Perelman School of Medicine, Gene Therapy Program, and Moderna, have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum.....»»