Molecular mechanism of ZDHHC18-mediated palmitoylation of cGAS in innate immunity inhibition
Cyclic GMP-AMP synthase (cGAS), a double-stranded DNA (dsDNA) sensing protein, plays an important role in the strong innate immune response induced by pathogen derived nucleic acids......»»
Shedding light on the mechanism of yeast DNA repair
DNA damage is a cellular phenomenon that introduces structural abnormalities in double-stranded DNA. External factors, such as radiation or chemical agents, as well as internal factors, such as blocked DNA replication, can generate double-strand brea.....»»
Bacterial defense strategy has potential application in genome editing
Scientists who have described in a new study the step-by-step details of a bacterial defense strategy see the mechanism as a promising platform for development of a new genome-editing method......»»
Light microscopy study reveals molecular density changes during mitotic chromosome condensation
A team of scientists studying cell division developed a special light microscopy system and used it to analyze the molecular density of cellular environments. Their results provide a novel insight into mitotic chromosome condensation in living human.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
Discovery of a hidden epigenetic clock in mitochondria reveals a "lifespan limit line"
Building on their work on epigenetics of aging and transposable elements, researchers Dr. Ádám Sturm and Dr. Tibor Vellai from Eötvös Loránd University have made another advance in understanding the molecular mechanisms of aging. Their latest st.....»»
Q&A: Expert explains how recent Supreme Court decisions and a shift in judicial tactics are reshaping US politics
In the wake of recent Supreme Court terms with controversial decisions on presidential immunity, abortion and other hot-button issues, public trust in the court sits at historic lows......»»
From antiquity to adaptation: Tracing the genetic journey of east Asian chestnut varieties
Uncovering the genetic saga of Castanea trees, a study maps their evolutionary journey and local climate adaptations. This research reveals the genetic markers and molecular mechanisms that have allowed these nut fruit trees to adapt and flourish acr.....»»
Controlling molecular electronics with rigid, ladder-like molecules
As electronic devices continue to get smaller and smaller, physical size limitations are beginning to disrupt the trend of doubling transistor density on silicon-based microchips approximately every two years, according to Moore's law. Molecular elec.....»»
Researchers discover rejuvenation mechanism in unicellular organisms
A team of scientists from the Cluster of Excellence "Balance of the Microverse" has discovered a previously unknown rejuvenation mechanism in unicellular organisms. They studied unicellular microalgae, which serve as the basis of food chains in the o.....»»
Scientists discover novel receptor recognition mechanism for alphavirus
Eastern Equine Encephalitis virus (EEEV), an alphavirus, can cause central nervous system infections that can lead to severe encephalitis with a mortality rate of over 30%......»»
Research unravels dual role of membrane protein in rice ethylene signal transduction
A research team, led by Professor Zhang Jinsong from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences, revealed insights into the mechanism by which the membrane protein MHZ3 collaborates with the ethylene.....»»
Researchers synthesize molecular aggregates for solar energy applications
No molecule stands alone—they need others, at least when it comes to being able to display useful photophysical, electronic, and chemical properties. When individual molecules combine into an aggregate, or a complex of two or more molecules, they b.....»»
Single nucleosomes tracked in live cells during cell division using super-resolution microscopy
Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism by which DNA condenses during mitosis is still poor.....»»
A small molecular glue that increases P53 level and suppresses tumor growth in vivo
Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, and there has been a lac.....»»
Physicists observe key minuscule molecular interactions in ultra-fast atomic processes
An international team of scientists is the first to report incredibly small time delays in a molecule's electron activity when the particles are exposed to X-rays......»»
Self-repairing mitochondria use novel recycling system, study finds
Mitochondria depend on a newly discovered recycling mechanism identified by scientists at The Hospital for Sick Children (SickKids)......»»
Surprising mechanism for removing dead cells identified
Billions of our cells die every day to make way for the growth of new ones. Most of these goners are cleaned up by phagocytes—mobile immune cells that migrate where needed to engulf problematic substances. But some dying or dead cells are consumed.....»»
Twisted molecular wires exhibit high single-molecule conductance
From the high-voltage wires that carry electricity over long distances, to the tungsten filaments in our incandescent lights, we may have become accustomed to thinking that electrical conductors are always made of metal. But for decades, scientists h.....»»
Newly discovered, free-living eukaryote is the first known to have lost its mitochondria
An international team of geneticists and molecular biologists has discovered the first-known, free-living eukaryote to have lost its mitochondria. In their study, published in Nature Communications, the group found the eukaryote while investigating t.....»»
Proteins for skin strength also control cell signaling, study suggests
An extensive family of proteins that gives human skin mechanical strength also appears to organize molecular signals that control skin cell activity, a study led by UT Southwestern Medical Center researchers shows. The team's findings, published in D.....»»