Molecular "hub" regulates gene-silencing proteins
To keep their vital functions in balance, many organisms use small snippets of RNA to "silence" messenger RNAs that code for certain proteins. New research from FMI scientists has revealed a molecular hub that integrates the activities of different p.....»»
A small molecular glue that increases P53 level and suppresses tumor growth in vivo
Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, and there has been a lac.....»»
Physicists observe key minuscule molecular interactions in ultra-fast atomic processes
An international team of scientists is the first to report incredibly small time delays in a molecule's electron activity when the particles are exposed to X-rays......»»
Lipid nanoparticle mRNA therapy improves survival in mouse models of maple syrup urine disease
Researchers from the University of Pennsylvania, Perelman School of Medicine, Gene Therapy Program, and Moderna, have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum.....»»
Ancient microbes linked to evolution of human immune proteins
When you become infected with a virus, some of the first weapons your body deploys to fight it are those passed down to us from our microbial ancestors billions of years ago. According to new research from The University of Texas at Austin, two key e.....»»
Twisted molecular wires exhibit high single-molecule conductance
From the high-voltage wires that carry electricity over long distances, to the tungsten filaments in our incandescent lights, we may have become accustomed to thinking that electrical conductors are always made of metal. But for decades, scientists h.....»»
Newly discovered, free-living eukaryote is the first known to have lost its mitochondria
An international team of geneticists and molecular biologists has discovered the first-known, free-living eukaryote to have lost its mitochondria. In their study, published in Nature Communications, the group found the eukaryote while investigating t.....»»
Proteins for skin strength also control cell signaling, study suggests
An extensive family of proteins that gives human skin mechanical strength also appears to organize molecular signals that control skin cell activity, a study led by UT Southwestern Medical Center researchers shows. The team's findings, published in D.....»»
Researchers teach artificial intelligence about frustration in protein folding
Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial intelligence (AI) technology has made it possible to predict.....»»
Unveiling the intricate and subtle dance of proteins: Understanding how parasites disarm host defenses
Pathogens hijack host cell functions by expressing or secreting effector proteins, creating environments conducive to their survival and reproduction. These pathogenic microorganisms—including eukaryotic parasites, prokaryotic bacteria, and viruses.....»»
Sea anemone study identifies potentially regenerative stem cells linked to conserved genes
The sea anemone Nematostella vectensis is potentially immortal. Using molecular genetic methods, developmental biologists led by Ulrich Technau from the University of Vienna have now identified possible candidates for multipotent stem cells in the se.....»»
As X shuts down in Brazil, is the Apple App Store silencing removing VPNs?
As X shuts down in Brazil, is the Apple App Store silencing removing VPNs?.....»»
New AI tool captures how proteins behave in context
A fish on land still waves its fins, but the results are markedly different when that fish is in water. Attributed to renowned computer scientist Alan Kay, the analogy is used to illustrate the power of context in illuminating questions under investi.....»»
Turning wastewater into valuable proteins with genetically modified yeast
The growing world population means that the environment is under great strain. Agriculture takes up large land areas and discharges nutrients to the surrounding environment. At the same time, there is tremendous pressure on the aquatic environment fr.....»»
Unraveling modern bread wheat from the genes up
A genomic resource for the wild grass species Tausch's goatgrass (Aegilops tauschii) has been developed by a team of international researchers led by KAUST. This new understanding will accelerate gene discovery research and shed new light on the stor.....»»
Chromatin structure found to play a key role in canine social behavior evolution
A study on dogs found that chromatin's spatial structure has a significant role in the evolution of social behavior. Chromatin, the compact form of DNA, not only packages genetic material but also plays a crucial role in gene regulation......»»
Light-responsive gene regulation at the mRNA level
Researchers at the University of Bayreuth have established a new optogenetic approach that can control the bacterial production of proteins at the mRNA level using blue light. The new system gates the activation of the genetic substance particularly.....»»
AI, computation, and the folds of life: Supercomputers help train a software tool for the protein modeling community
Form follows function, and this is especially true for life's building blocks—proteins. The folds and shape of molecular proteins reveal their function in supporting life......»»
Modified solvents achieve vastly increased potentials for oxidation
A team of scientists headed by Professor Ingo Krossing, Professor of Molecular and Coordination Chemistry at the University of Freiburg's Institute of Inorganic and Analytical Chemistry, has succeeded in significantly increasing the potential for oxi.....»»
Rewriting the evolutionary history of critical components of the nervous system
A new study has rewritten the conventionally understood evolutionary history of certain proteins critical for electrical signaling in the nervous system......»»
Researchers identify body"s "quality control" regulator for protein folding, could lead to targeted treatments
Anyone who's tried to neatly gather a fitted sheet can tell you: folding is hard. Get it wrong with your laundry and the result can be a crumpled, wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins with an origami-.....»»