Lipid nanoparticle mRNA therapy improves survival in mouse models of maple syrup urine disease
Researchers from the University of Pennsylvania, Perelman School of Medicine, Gene Therapy Program, and Moderna, have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum.....»»
Study finds aquatic vegetation removal benefits health and economy
Turning aquatic vegetation near agricultural land into compost simultaneously eradicates habitat for disease-carrying snails while improving agricultural output and increasing incomes in northern Senegal, Cornell researchers have found......»»
Pick up Apple"s M4 iPad Pro for $849 with delivery by Christmas
Time is running out to pick up an M4 iPad Pro with delivery by Christmas. Both 11-inch and 13-inch models are available at up to $200 off.Save on Apple's iPad Pro before Christmas.Best Buy has the lowest price today on Apple's M4 iPad Pro 11-inch, wh.....»»
Ice is melting, seas are rising—how scientists are tracking the changes
Will the sea rise by 20 cm or 3 meters by 2100? This is obviously an interesting question to answer. Predicting the sea level in 75 years requires precise calculations and correct models of the melting of the ice from, e.g., Greenland. To do so, rese.....»»
Machine learning framework improves groundwater recharge estimates in Western Australia
A new study led by Griffith University has unveiled a machine learning-based framework to accurately estimate groundwater recharge in the Perth Basin, with a particular focus on the Gnangara groundwater system......»»
Syphilis had its roots in the Americas, archaeological bone study suggests
In spring 1495, the Italian campaign of Charles VIII of France was interrupted by an intense outbreak of an apparently unknown illness—a disease of high mortality that quickly engulfed the whole of Europe and left its survivors with life-changing i.....»»
Building a backbone: Scientists recreate the body"s "GPS system" in the lab
Scientists at the Francis Crick Institute have generated human stem cell models which, for the first time, contain notochord—a tissue in the developing embryo that acts like a navigation system, directing cells where to build the spine and nervous.....»»
Dormant massive black hole in the early universe challenges existing models
Scientists have spotted a massive black hole in the early universe that is "napping" after stuffing itself with too much food. Like a bear gorging itself on salmon before hibernating for the winter, or a much-needed nap after Christmas dinner, this b.....»»
Topographic complexity: A blueprint for biodiversity conservation
In the intricate landscapes of karst regions, the subtle interplay of slopes, soils, and microclimates is shaping the survival of plant species. A new study published in Forest Ecosystems has revealed how the unique structure of dolines—topographic.....»»
Wind alters snow crystals, impacting climate models
Wind tunnel experiments conducted by the WSL Institute for Snow and Avalanche Research SLF show how snow crystals change in the wind. The findings could force climate researchers to adjust their models—particularly in the polar regions, where snow.....»»
Mathematics reveals how the size of cellular components is regulated
Sebastian Persson uses mathematical models as a complement to experiments to study biological systems in his doctoral thesis. He has also developed software to more efficiently work with dynamic models......»»
Unlocking the brain: Peptide-guided nanoparticles deliver mRNA to neurons
Penn Engineers have modified lipid nanoparticles (LNPs)—the revolutionary technology behind the COVID-19 mRNA vaccines—to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthroug.....»»
Patients whose allergies cause the sniffles have different fungi living in their noses, scientists discover
Nearly a quarter of Portuguese adults have allergies that cause a runny nose. This respiratory disease, formally called allergic rhinitis and frequently associated with asthma, is a common problem around the world, and the upper airway is a key targe.....»»
What a century-old grapevine reveals about a disease that plagues wine country
A century-old grapevine cutting is providing new clues into the history of a deadly plant pathogen that is decimating crops across the globe......»»
Novel platinum complex shows strong antiproliferative effects with low toxicity in preclinical prostrate cancer models
Prostate cancer remains a global health challenge, ranking as the second most commonly diagnosed cancer among men. Although treatments like androgen deprivation therapy have been effective for early-stage prostate cancer, advanced stages, such as cas.....»»
Metal-organic framework film improves isomer separation control
Researchers have developed a method to enhance the separation of chemical isomers by controlling molecular diffusion. Utilizing a metal-organic framework thin film, they applied dynamic chemical interactions to adjust pore dynamics and reverse isomer.....»»
Save $50 on the Google Pixel Watch 2 and 3 at Best Buy
There are great savings on the latest two Google Pixel Watch models right now at Best Buy. Here's a look at the best option for you......»»
Video: The strange chemistry of Mexican Coke
Mexican Coke tastes different than American Coke; after all, it's sweetened using cane sugar instead of high-fructose corn syrup......»»
Do the fastest-spinning pulsars contain quark matter?
Neutron stars are so named because in the simplest of models they are made of neutrons. They form when the core of a large star collapses, and the weight of gravity causes atoms to collapse. Electrons are squeezed together with protons so that the co.....»»
New method speeds up protein study, aiding disease treatment research
Protein complexes are important for the majority of vital processes in the cell and human body, such as producing energy, copying DNA and regulating the immune system......»»
Newly discovered degradation process for mRNA could lead to clinical treatments
Researchers at the University of Würzburg have discovered a process that breaks down mRNA molecules in the human body particularly efficiently. This could be useful, for example, in the treatment of cancer. The study is published in Molecular Cell......»»