How a mitochondrial metabolite causes inflammation and disease
A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response. Mitochondria are functional units of our cells that fulfill important tasks, i.e. chemical reactions, for the functio.....»»
Scientists learn how to drug wily class of disease-causing enzymes
UCSF scientists have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases from Parkinson's to cancer and have long been thought to be "undruggable.".....»»
Strawberry disease could threaten Hampton Roads" spring harvest
In a few weeks, strawberry growers in southeast Virginia will plant their crop to be harvested in May. But many are concerned about a disease that could drastically reduce next year's yield......»»
The Mosquito-Borne Disease ‘Triple E’ Is Spreading in the US as Temperatures Rise
Eastern equine encephalitis, which has a high mortality rate, is becoming more common in North America as climate changes expands the habitats of insects......»»
Why Polio Has Reemerged in Gaza
After a quarter of a century, the disease has returned to Gaza, prompting a campaign to immunize all of the territory's children against the virus......»»
This could increase your risk of Alzheimer’s disease more than anything: study
This could increase your risk of Alzheimer’s disease more than anything: study.....»»
Solving the side effect problem of siRNA drugs for genetic disease treatment
Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases. However, siRNA drugs have challenges because siRNAs often silence genes other than the target ones, causing side eff.....»»
Neolithic bones reveal isolated Yersinia pestis infections, not pandemics
Since the catastrophic pandemics of the Middle Ages, one disease has almost proverbially symbolized contagion and death: the plague. It is now known that the plague bacterium Yersinia pestis has been present in Central and Northern Europe for more th.....»»
Q&A: How single-cell and spatial proteomics reveal proteins" nuanced roles in health and disease
When Steve Carr, senior director of the Proteomics Platform at the Broad Institute of MIT and Harvard, began working in proteomics, the field was able to detect only the most abundant proteins in a given sample. In recent years, increasingly sensitiv.....»»
New mRNA and gene editing tools offer hope for dengue virus treatment
Dengue virus, a painful and sometimes fatal mosquito-borne infection well known in tropical countries, is surging rapidly across the planet. Now, 4 billion people live in places at risk for the disease, like the southeastern United States, which does.....»»
Researchers develop molecular biosensors that only light up upon binding to their targets
Biosensors—devices that use biological molecules to detect the presence of a target substance—have enormous potential for detecting disease biomarkers, molecules-in-action in diverse biological processes, or toxins and other harmful substances in.....»»
Moderna mRNA mpox vaccine shows promise in animal study
An experimental Moderna mRNA vaccine for mpox has demonstrated greater effectiveness than current shots in reducing disease symptoms and duration, according to an animal study published in the journal Cell on Wednesday......»»
Diagnosing oak wilt with the naked eye
University of Minnesota researchers developed a groundbreaking method for the rapid and accurate detection of oak wilt, a devastating disease threatening oak trees across North America. The disease is widespread in east-central and southeast Minnesot.....»»
Denmark reports cases of bluetongue disease that can be fatal to sheep but is harmless to humans
Denmark reported Tuesday cases of bluetongue in the country's east, a non-contagious, insect-borne viral disease that is harmless to humans but can be fatal for so-called ruminant animals—mainly sheep but also cows and goats......»»
Unveiling the molecular mechanisms linking aging with neurodegenerative diseases
Aging is the prime cause of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. But what exactly increases the prevalence of these brain disorders as one grows older? The molecular forces l.....»»
How stressed are you? Nanoparticles pave the way for home stress testing
Stress takes various shapes in our daily lives, from relentless work demands to the constant rush of the school run. But ignoring high stress levels can lead to serious health issues like depression and Alzheimer's disease. So what if checking your s.....»»
2018 to 2021 saw no change in rates of intimate partner homicide among women
U.S. rates of intimate partner homicide involving female victims did not significantly change from 2018 to 2021, according to research published in the Aug. 29 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekl.....»»
Q&A: Protecting people and animals from eastern equine encephalitis
With mosquito-borne disease eastern equine encephalitis currently circulating in New England, Emily Reinhardt '20 (CAHNR), assistant clinical professor, and Ash Nakashima, graduate student, in UConn's Department of Pathobiology and Veterinary Science.....»»
"Silent" mutations found to have repercussions beyond their own gene
Genetic disorders—like cystic fibrosis and Huntington's disease—are considered incurable, with gene mutations occurring in essentially every cell of the body. Gene mutations occur when one nucleotide in a codon is switched. In non-synonymous muta.....»»
New vaccine protects cattle from deadly tick-borne disease
University of Missouri researchers are working to develop the first-ever vaccine proven to protect cattle from a devastating tick-borne cattle disease known as bovine anaplasmosis. The research is vital to the state's economy as it aims to protect Mi.....»»
Engineers design lookalike drug nanocarrier to evade lung"s lines of defense
A drug-carrying molecule designed to cure disease by slipping past the lung's natural defenses offers new hope for people with chronic or deadly respiratory diseases, say its creators, researchers in assistant professor Liheng Cai's Soft Biomatter La.....»»