Glucagon receptor structures uncover new arrestin interaction mechanism
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arresti.....»»
Researchers examine protein arrangement in cell membrane that triggers programmed cell death
How can molecular structures be analyzed when the resolution of the techniques available is not sufficient? Researchers from the fields of physics, chemistry and medicine at Heinrich Heine University Düsseldorf (HHU) have combined and further develo.....»»
Hijacking the command center of the cell: Nuclear parasites in deep-sea mussels
Most animals live in intimate relationships with bacteria. Some of these bacteria live inside the cells of their hosts, but only very few are able to live inside cell organelles (structures inside the cell, like organs in the body). One group of bact.....»»
AI meets biophysics: New approach identifies critical interaction points in cancer-related proteins
Researchers at Auburn University, in collaboration with scientists from the University of Basel and ETH Zurich, have made an advance in the fight against cancer. The team, led by Dr. Rafael Bernardi, Associate Professor of Biophysics in the Departmen.....»»
New method captures the stochastic dynamics in coherent X-ray imaging at the nanoscale
Coherent X-ray imaging has emerged as a powerful tool for studying both nanoscale structures and dynamics in condensed matter and biological systems. The nanometric resolution together with chemical sensitivity and spectral information render X-ray i.....»»
Scientists uncover hidden source of snow melt: Dark brown carbon
Wildfires leave potent climate heaters behind in their wake, particles that enhance the absorption of sunlight and warm the atmosphere. Dropped on snow like a wool poncho, these aerosols darken and decrease the surface reflectance of snowy places......»»
Researchers explore key interaction sites and pathways in ammonia capture
The design and development of high-performance materials are crucial for efficient ammonia capture. Generally, these materials are characterized by abundant ammonia adsorption sites and rapid ammonia transport channels, enabling the effective capture.....»»
Drosophila study discovers mechanism that could control longevity, cancer cell production
Researchers at UC Merced have used fruit flies to uncover a cellular process common to many organisms that could dramatically impact the understanding of cancer and aging......»»
Cold-atom simulator demonstrates quantum entanglement between electronic and motional states
Researchers from the Institute for Molecular Science have revealed quantum entanglement between electronic and motional states in their ultrafast quantum simulator, generated by the repulsive force due to the strong interaction between Rydberg atoms......»»
Cells use alternative splicing to regulate gene expression, research suggests
Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism increases the diversity of proteins that can be generat.....»»
Ancient viral genomes preserved in glaciers reveal climate history—and how viruses adapt to climate change
As humans alter the planet's climate and ecosystems, scientists are looking to Earth's history to help predict what may unfold from climate change. To this end, massive ice structures like glaciers serve as nature's freezers, archiving detailed recor.....»»
Study finds RNA molecule controls butterfly wing coloration
A team of international researchers has uncovered a surprising genetic mechanism that influences the vibrant and complex patterns on butterfly wings. In a study published in the Proceedings of the National Academy of Sciences, the team, led by Luca L.....»»
Novel encoding mechanism unveiled for particle physics
In the development of particle physics, researchers have introduced an innovative particle encoding mechanism that promises to improve how information in particle physics is digitally registered and analyzed. This new method, focusing on the quantum.....»»
Big-name publishers are refusing to let Apple Intelligence train on data
Website owners have a simple mechanism to tell Apple Intelligence not to scrape the site for training purposes, and reportedly major platforms like Facebook and the New York Times are using it.Future expansions to Apple Intelligence may involve more.....»»
Shedding light on the mechanism of yeast DNA repair
DNA damage is a cellular phenomenon that introduces structural abnormalities in double-stranded DNA. External factors, such as radiation or chemical agents, as well as internal factors, such as blocked DNA replication, can generate double-strand brea.....»»
Protein mutant stability can be inferred from AI-predicted structures
Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI......»»
Bacterial defense strategy has potential application in genome editing
Scientists who have described in a new study the step-by-step details of a bacterial defense strategy see the mechanism as a promising platform for development of a new genome-editing method......»»
Supercomputer simulations reveal the nature of turbulence in black hole accretion disks
Researchers at Tohoku University and Utsunomiya University have made a breakthrough in understanding the complex nature of turbulence in structures called accretion disks surrounding black holes, using state-of-the-art supercomputers to conduct the h.....»»
Researchers map 50,000 of DNA"s mysterious "knots" in the human genome
Researchers have mapped 50,000 of DNA's mysterious "knots" in the human genome. The innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer......»»
Simulation model shows ribosome tunnel"s impact on protein structures
Researchers at University of Tsukuba have developed a new model that simulates the internal environment of a ribosome—the cellular site of protein synthesis. Using computer simulations, they have analyzed the structures of various proteins within t.....»»
What makes a supercluster?
By eye, it's impossible to pick out the exact boundaries of the superclusters, which are among the largest structures in the universe. But that's because they are not defined by their edges, but by the common motion of their components......»»