Genetically engineered cell therapies with mRNA lipid nanoparticles for transferrable platelets
Platelet transfusions are essential in managing bleeding and hemostatic dysfunction, and can be expanded to be used as cell therapy for a variety of diseases. The efforts to create such cell therapies require that researchers modify donor platelets t.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
Study reveals bioactive power of a natural spearmint compound against weeds
A recent study reveals the natural compound (-)-carvone in spearmint as a potent and sustainable alternative to chemical herbicides. This research demonstrates how (-)-carvone targets and degrades microtubules in weeds, inducing cell death and inhibi.....»»
Researchers investigate cell-free DNA as early sepsis marker in foals
It's hard to be a horse. It's especially hard to be a newborn foal, dropped into a world of microbes and bacteria with your sole initial defense against devastating infections being the antibodies you get from your mother's milk, or colostrum. Resear.....»»
Tomato ripening study highlights cell wall component interactions
Tomato fruit ripening involves intricate biochemical and structural changes, particularly within the cell wall, which are vital for the fruit's final texture and quality. These changes include modifications in polysaccharides and proteins, but the sp.....»»
How engineered walnuts combat drought through grafting
Drought is a major threat to walnut production globally, often resulting in lower yields and weaker trees. While grafting has traditionally been used to improve the resilience of fruit and nut trees, the exact mechanisms of signal transfer between ro.....»»
Hitachi Vantara and Broadcom help organizations modernize their cloud infrastructure
Hitachi Vantara and Broadcom announced a new private and hybrid cloud solution. The co-engineered solution brings together Hitachi Vantara’s integrated systems solution of Unified Compute Platform (UCP) RS with VMware Cloud Foundation to assist.....»»
Manganese nanoparticles can more than double availability of world"s potable water, say scientists
Manganese ferrite nanoparticles could lead to a substantial surge in the availability of drinking water globally when used to modify the filtering sheets currently used in water treatment plants, according to scientists......»»
Mapping the sex life of malaria parasites at single cell resolution reveals genetics underlying transmission
Malaria is caused by a eukaryotic microbe of the Plasmodium genus, and is responsible for more deaths than all other parasitic diseases combined. In order to transmit from the human host to the mosquito vector, the parasite has to differentiate into.....»»
Schools are competing with cell phones. Here"s how they think they could win
Isabella Pires first noticed what she calls the "gradual apathy pandemic" in eighth grade. Only a handful of classmates registered for service projects she helped organize at her Massachusetts school. Even fewer actually showed up......»»
The promise of synthetic cells
For over a decade, scientists have made extraordinary progress on the long-held dream of fabricating an entire cell from nonliving molecules and materials......»»
Ultra-sensitive photothermal microscopy technique detects single nanoparticles as small as 5 nm
The detection of individual particles and molecules has opened new horizons in analytical chemistry, cellular imaging, nanomaterials, and biomedical diagnostics. Traditional single-molecule detection methods rely heavily on fluorescence techniques, w.....»»
Single nucleosomes tracked in live cells during cell division using super-resolution microscopy
Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism by which DNA condenses during mitosis is still poor.....»»
Stranded student helps design synthetic polymers to combat fungal infections
Every year, more than 2 million people are affected by invasive fungal infections, which are often caused by Candida species and are associated with high mortality rates. The development of new therapies is progressing very slowly. Demand is increasi.....»»
VW scales back plans for battery cell plants in Europe, North America
VW expects to start production next year at a new gigafactory in Germany, but said it may take longer to scale up battery cell capacity at plants in Spain and Canada......»»
The Next Frontier for mRNA Could Be Healing Damaged Organs
Researchers are testing the use of mRNA to get damaged livers to repair themselves, in a move that could one day lessen the need for organ transplants......»»
Hydrogels can learn to play Pong
Work could lead to new "smart" materials that can learn and adapt to their environment. This electroactive polymer hydrogel "learned" to play Pong. Credit: Cell Reports Physical Science/Strong et al......»»
FDA green-lights fall COVID-19 boosters
Updated mRNA vaccines from Pfizer and Moderna are ready to roll. Enlarge (credit: Getty Images) As the COVID-19 case count continues to tick upward, the US Food and Drug Administration has approved an updated vaccine for.....»»
Low-cost flexible metasurfaces to increase the efficiency of optoelectronic devices
Metasurfaces are two-dimensional counterparts of metamaterials, which are artificial materials that possess unusual characteristics. With a variety of fascinatingly innovative and diverse uses, these specially-prepared surfaces with engineered patter.....»»
Novel silica nonwoven fabric scaffold enhances understanding of cell-to-cell interactions
Communication and coordination among different cells are fundamental aspects that regulate many functions in our body. This process, known as paracrine signaling, involves the release of signaling molecules by a cell into its extracellular matrix (EC.....»»
Novel carbon nanohorn-based treatment enables efficient delivery of drugs in cancer therapy
Cancer remains one of the most challenging diseases to treat due to its complexity and tendency to metastasize (spread into, or invade, nearby tissues or distant places in the body to form new tumors). Traditional therapies, such as chemotherapy and.....»»