G-quadruplex-forming DNA molecules enhance enzymatic activity of myoglobin
A collaboration led by Distinguished Professor Dr. Kazunori Ikebukuro from Tokyo University of Agriculture and Technology (TUAT), Japan, discovered that G-quadruplex (G4)-forming DNA binds myoglobin through a parallel-type G4 structure. Through the G.....»»
First set of rational design principles for chaotropic membrane transporters
The challenge of internalizing impermeable molecules into cells persists in drug development, particularly concerning water-soluble bioactive compounds that cannot diffuse across the cell membrane. To overcome this problem, various artificial transpo.....»»
Novel strategy proposed for selectively targeting G-quadruplex at specific genome loci
DNA G-quadruplexes (G4s) are a type of quadruple helix structure formed by a continuous guanine-rich DNA sequence. Although DNA G4s are thought to be involved in various biological processes, in many cases their causative effects are largely unclear.....»»
Scientists investigate fast reaction dynamics in synthetic molecules immobilized in porous protein cages
Immobilizing small synthetic molecules inside protein crystals proves to be a promising avenue for studying intermediate compounds formed during chemical reactions, report scientists from Tokyo Tech. By integrating this method with time-resolved seri.....»»
Engineers develop advanced optical computing method for multiplexed data processing and encryption
Engineers at the University of California, Los Angeles (UCLA) have unveiled a major advancement in optical computing technology that promises to enhance data processing and encryption. The work is published in the journal Laser & Photonics Reviews......»»
New probe reveals water-ice microstructures
Ice is believed to have played a crucial role in the emergence of life. One reason is that organic molecules can be excluded into the gaps between the crystal lattice by orderly arranged water molecules, leading to the concentration of organic compou.....»»
Study finds ways to enhance transcription factor activity
Transcription factors regulate gene expression by binding specific sequences on DNA, which is an essential step to producing messenger RNAs from protein-coding genes. Denes Hnisz's lab, in collaboration with Martin Vingron's lab at the MPIMG, has dis.....»»
Unleashing the potential of high-spin polymers for next-gen optoelectronics and spintronics
The study of open-shell molecules, particularly those with high-spin ground states, has unveiled significant potential in organic electronics and magnetism. These molecules, characterized by unpaired electrons, exhibit unique properties such as long.....»»
Try these 7 iPad Pro apps to enhance your productivity
The beauty of the iPad and iPadOS is that you have access to the app store. Some say that the iPadOS software tends to bog the user experience down, especially in a productivity setting, but I disagree. Between the nearly 2 million apps you have acce.....»»
LogRhythm’s enhancements boost analyst efficiency
LogRhythm announced its 9th consecutive quarterly release. In the AI-ready world, LogRhythm empowers security teams with the highest integrity data in the security industry to enhance the output of the AI tools used to defend organizations from cyber.....»»
Maintaining human oversight in AI-enhanced software development
In this Help Net Security interview, Martin Reynolds, Field CTO at Harness, discusses how AI can enhance the security of software development and deployment. However, increased reliance on AI-generated code introduces new risks, requiring human overs.....»»
New AirPods with IR camera coming to enhance Spatial Audio in Apple Vision Pro
New AirPods with IR camera coming to enhance Spatial Audio in Apple Vision Pro.....»»
How 36,000 buried tea bags help explain global decomposition
Co-developed by Umeå university, a method to measure the decay of plant material with the help of simple tea bags has quickly become the standard in scientific research as well as a favorite teaching activity throughout the world......»»
Graph learning modules enhance drug-target interaction predictions
The identification of drug-target Interactions (DTIs) represents a pivotal link in the process of drug development and design. It plays a crucial role in narrowing the screening range of candidate drug molecules, thereby facilitating the reuse of dru.....»»
Discovering new anti-aging secrets from the world"s longest-living vertebrate
New experimental research shows that muscle metabolic activity may be an important factor in the incredible longevity of the world's oldest living vertebrate species—the Greenland shark. These findings may have applications for conservation of this.....»»
New photonic crystal approach can enable sensitive and affordable detection of biomarkers
Biomarkers are small molecules of interest to researchers, because they can indicate underlying diseases, often even before symptoms even appear. However, detecting these markers can be challenging as they are often present in very low quantities, es.....»»
Scientists develop most sensitive method yet for observing single molecules
Scientists at the University of Wisconsin–Madison have developed the most sensitive method yet for detecting and profiling a single molecule—unlocking a new tool that holds potential for better understanding how the building blocks of matter inte.....»»
Lava continues to flow from Iceland volcano but not at powerful level as eruption
Lava continued to spurt from a volcano in southwestern Iceland on Thursday but the activity had calmed significantly from when it erupted a day earlier......»»
New modified CRISPR protein can fit inside virus used for gene therapy
Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells. Hongjian Wang and colleagues a.....»»
Antibiotic pollution disrupts the gut microbiome and blocks memory in aquatic snails, study finds
Antibiotics prevent snails from forming new memories by disrupting their gut microbiome—the community of beneficial bacteria found in their guts......»»
Chocolate"s tasty flavors might pose a health risk in other desserts
What makes chocolate taste and smell so delicious? Chemistry, of course. A variety of molecules work together to create that unmistakable aroma, but those same molecules might carry some unwanted health effects if there are too many around. According.....»»