Downstream RNA hairpins found orchestrating mRNA translation
Research led by Duke University, Durham, has discovered a situation-dependent traffic jam in mRNA translation caused by RNA hairpins leading to higher translation of upstream start codons (uAUGs)......»»
Messenger RNAs with multiple "tails" could lead to more effective therapeutics, say researchers
Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines. But mRNAs, which are genetic sequences that instruct the body to produce proteins, are also being devel.....»»
Research seeks to develop mRNA lipid nanoparticles for next-generation oral cancer tumor suppressor therapy
A study aiming to develop a lipid nanoparticles (LNP) platform for treating oral squamous cell carcinoma (OSCC) utilizing p53 mRNA was presented at the 102nd General Session of the IADR, which was held in conjunction with the 53rd Annual Meeting of t.....»»
How cells manage their mRNA stockpile and its output
In a typical cell, genes encoded in DNA are used to make messenger RNA (mRNA), which is used to make proteins, and this process of gene expression keeps the cell running. Gene expression is regulated in each cell such that specific genes are turned o.....»»
The best movies on Peacock right now (March 2024)
The best movies on Peacock in March include Lost in Translation, Back to the Future, Arrival, Kill Bill, Oppenheimer, and even more of your favorite films......»»
Hydrogel spheres compose a microporous structure for localized mRNA delivery
In a significant leap forward in the realm of regenerative medicine, a team at the Terasaki Institute for Biomedical Innovation has introduced a pioneering approach to mRNA therapy using microspheres made of gelatin methacryloyl (GelMA)—a gelatin-b.....»»
New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control
Inspired by the design of space shuttles, Penn Engineering researchers have invented a new way to synthesize a key component of lipid nanoparticles (LNPs), the revolutionary delivery vehicle for mRNA treatments including the Pfizer-BioNTech and Moder.....»»
Investigators find that streams connected to groundwater show improved detoxification and microbial diversity
Streams with ample connections to shallow groundwater flowpaths have greater microbial diversity and are more effective at preventing toxic forms of metals—often products of upstream mining—from entering and being transported downstream. These st.....»»
Stabilizing mRNA vaccines for delivery to cells
Vaccines and therapies based on messenger RNA could be more readily delivered due to a non-toxic polymer that protects RNA and controls its release inside cells......»»
Discovery of a subset of human short introns that are spliced out by a novel mechanism
The well-known essential pre-mRNA splicing factor U2AF heterodimer (U2AF2–U2AF1) has been identified as mediating early splicing reactions in all introns of different lengths. However, Dr. Kazuhiro Fukumura in the Akila Mayeda lab at Fujita Health.....»»
Medicinal drugs pollute the St. Lawrence River, presenting possible risk to aquatic organisms: Study
A new study shows troubling levels of pharmaceutical pollution in the St. Lawrence River and its largest tributaries, especially near and downstream of urban areas. Some of the compounds detected even pose a moderate-to-high risk to aquatic organisms.....»»
Apple Podcasts offers transcripts for all shows in iOS 17.4
Apple has introduced a new feature for Apple Podcasts in iOS 17.4 that provides a transcript for seemingly nearly every podcast.Apple Podcasts appMachine translation has improved significantly in recent years, to the point that spoken word should be.....»»
How to use Translate with the Action Button in iOS 17
Apple's iOS 17.2 added a new option to the iPhone 15 Pro's Action button with the ability to start a translation. Here's how to do it, and how to pick the language you want.Apple has added a Translate option to the Action ButtonYou could already have.....»»
Searchlight Cyber adds AI-powered language translation to simplify dark web investigations
Searchlight Cyber has added AI-powered language translation into its dark web investigation and monitoring products DarkIQ and Cerberus. This enhancement gives cybersecurity professionals instant access to precisely translated results in English, all.....»»
Scientists Will Test a Cancer-Hunting mRNA Treatment
Strand Therapeutics has figured out a way to turn the molecule on and off in certain tissues to more precisely treat tumors......»»
Samsung Galaxy S24 translation feature will work with WhatsApp
It turns out that the language translation feature on the Samsung Galaxy S24 will work with third-party apps such as WhatsApp. The post Samsung Galaxy S24 translation feature will work with WhatsApp appeared first on Phandroid. One of the.....»»
Colorado"s new wolves are alive and well, but state officials face transparency concerns about releases
The 10 wolves set loose in Colorado in December 2023 as part of a historic state-led reintroduction are doing well, but the humans charged with orchestrating the multi-year effort addressed concerns this week about a lack of transparency about the re.....»»
Efficient antibody production "wobbles," new study finds
Molecular biology's central dogma posits a simple recipe for the construction of the human body: a DNA blueprint is transcribed into an RNA message, and the RNA message is translated into the proteins that make you. Translating the mRNA message is a.....»»
Researchers use machine learning to examine meanings across languages
How meanings align across languages suggests that translation and cross-cultural communication may be challenging, but researchers haven't been clear as to what characterizes this alignment, and what factors might affect it......»»
Mineral coatings could enable shelf-stable mRNA therapies
A protective mineral coating identified by University of Wisconsin–Madison biomedical engineering researchers could allow powerful messenger RNA therapeutics like COVID-19 vaccines to be stored at room temperature, making them more accessible to lo.....»»
"X-ray vision" for investigation of mRNA nanomedicines
A new technology co-developed at EMBL Hamburg provides new insights into mRNA pharmaceuticals and other nanomedicines, which can be helpful for the development of new products.....»»