Decoding the cell signals between young proteins and their "chaperones"
Of the 25,000 different proteins in the human body, insulin, antibodies, and collagen are among the few that perform their biological jobs by literally folding into 3D shapes......»»
Research shows that "softer" proteins can cross into the nucleus quicker
Researchers at the Francis Crick Institute and King's College London have discovered that how soft or rigid proteins are in certain regions can dictate how fast or slow they enter the nucleus......»»
Research holds promise for liver regeneration
A new study titled "Biomimetic hepatic lobules from three-dimensional imprinted cell sheets" has been led by Prof. Yuanjin Zhao of the Department of Hepatobiliary Surgery, Hepatobiliary Institute, Nanjing Drum Tower Hospital, Medical School, of Nanji.....»»
Researchers reveal new cellular mechanical transducer
A research team has uncovered a novel regulator governing how cells respond to mechanical cues. Their findings appear in Nature Cell Biology......»»
Saturated soils could impact survival of young trees planted to address climate change
The saturated soil conditions predicted to result from increased rainfall in the UK's upland regions could have a knock-on effect on the ambition to create more woodland in the fight against climate change, a new study has found......»»
Genes spatially organize for efficient mRNA splicing, study shows
The nucleus of each of your cells contains all the genetic information (the genome) necessary to build every type of cell and protein in your entire body. Like a complex library in a tiny space 50 times smaller than the width of a human hair, genes a.....»»
Team develops an epigenome editing toolkit to dissect the mechanisms of gene regulation
Understanding how genes are regulated at the molecular level is a central challenge in modern biology. This complex mechanism is mainly driven by the interaction between proteins called transcription factors, DNA regulatory regions, and epigenetic mo.....»»
Shaping up how red blood cell deformability is assessed—researchers develop new approach
Red blood cells (RBCs) transport oxygen throughout the body and are able to pass through a complex of narrow capillaries due to their ability to deform. "The deformability of RBCs is an important indicator of their health and functionality, and chang.....»»
Researchers discover new function of oncoproteins
Researchers at the University of Würzburg have discovered a new function of the oncoprotein MYCN: It not only helps cancer cells to grow stronger, but also makes them more resistant to drugs. The study is published in Molecular Cell......»»
New technology changes how proteins in individual cells are studied
Researchers from Karolinska Institutet, together with Pixelgen Technologies, have developed and applied a technique that makes it possible to map proteins in individual cells in a completely new way. Not only is it now possible to measure the amount.....»»
U.S. Government Needs to ‘Get It Right’ on Artificial Intelligence
“We can't afford to get this wrong—again,” Shalanda Young, the director of the Office of Management and Budget, tells TIME. Artificial intelligence has been a tricky subject in Washington. Most lawmakers agree that it poses.....»»
Researchers study the intricacies of homologous recombination and abnormal chromosome bridges
Keeping the genetic information stored in genomic DNA intact during the cell division cycle is crucial for almost all lifeforms. Extensive DNA damage invariably causes various adverse genomic rearrangements, which can lead to cell death in the best c.....»»
Researchers reveal how molecular roadblocks slow the breakdown of cellulose for biofuels
Cellulose, which helps give plant cell walls their rigid structure, holds promise as a renewable raw material for biofuels—if researchers can accelerate the production process. Compared to the breakdown of other biofuel materials like corn, breakin.....»»
Study reveals differences in DNA folding between neurons and other brain cells, links them to cell functions
Researchers from Skoltech and their colleagues have investigated nerve cell regulation. Mounting knowledge of regulation mechanisms could enable a better understanding of how the healthy brain operates and what goes wrong in developmental and oncolog.....»»
Study sheds light on cancer cell "tug-of-war"
Understanding how cancerous cells spread from a primary tumor is important for any number of reasons, including determining the aggressiveness of the disease itself. The movement of cells into the extracellular matrix (ECM) of neighboring tissue is a.....»»
Study identifies early warning signals for the end of the African humid period
The transition from the African humid period (AHP) to dry conditions in North Africa is the clearest example of climate tipping points in recent geological history. They occur when small perturbations trigger a large, non-linear response in the syste.....»»
Decoding development: mRNA"s role in embryo formation
A new study at Hebrew University reveals insights into mRNA regulation during embryonic development. The study sheds light on the intricate process of mRNA regulation during embryonic development, providing novel insights into how pluripotent cells a.....»»
How a "conductor" makes sense of chaos in early mouse embryos
Early embryonic development is tumultuous. It involves a rapid sequence of events, including cell division, differentiation, and lots of compartments moving around within each cell. Like an orchestra performance where each member of the band must sta.....»»
Laboratory and natural strains of intestinal bacterium turn out to have similar mutational profiles
Understanding mutational processes in a cell offers clues to the evolution of a genome. Most actively, mutation processes are studied in human cancer cells, while other genomes are often neglected......»»
Rich molecular language guides tiny liquid droplet formation in cells
Peering into a biological cell reveals a bustling microscopic world. The workhorses within this realm are specialized structures called organelles that perform vital cellular functions. Curiously, some organelles defy accepted convention: Instead of.....»»
Datadog Event Management helps teams reduce alert fatigue
Datadog released IT Event Management to its suite of AIOps capabilities. With Event Management, Datadog intelligently consolidates, correlates and enriches all alert events and important signals from Datadog and existing third-party observability too.....»»