Converting P450 peroxygenase into peroxidase via mechanism-guided protein engineering
Enzyme catalysis is a promising green solution for producing pharmaceuticals, fine chemicals, and biofuels. However, exploring their catalytic promiscuity to expand and enhance the capabilities of enzymes remains challenging......»»
Inverse-design method enhances performance and reliability of on-chip spectrometers
In a study published in Engineering, researchers from Nanjing University of Aeronautics and Astronautics and Zhejiang University have unveiled a pioneering approach to designing on-chip computational spectrometers, heralding a new era of high-perform.....»»
Machine learning accelerates discovery of high-temperature alloys
In a study recently published in Engineering, scientists from the University of Science and Technology Beijing, Guangdong Ocean University, and AiMaterials Research LLC have demonstrated a novel method to accelerate the discovery of refractory high-e.....»»
How a protein keeps gene clusters quiet in the cell nucleolus
In a discovery that sheds light on the complex mechanisms of gene regulation, scientists at EPFL have uncovered a critical role for the protein ZNF274 in keeping certain gene clusters turned off by anchoring them to the cell nucleolus. The study is p.....»»
Elucidating the mechanism of cell division during plant self-healing
When the stem of a plant is injured, the surrounding cells proliferate to repair and fuse the damaged tissue, eventually restoring function. This self-healing property is utilized in grafting techniques to propagate fruit and vegetable plants......»»
Scientists identify structural basis of stitched-together protein complexes that recycle most proteins in cells
Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell's recycling process for obsolete and misshapen proteins—known as proteasomes—are formed......»»
Presence of bacteria in soil makes flowers more attractive to pollinators, study shows
Bacteria that live in soil and help roots fix nitrogen can boost certain plants' capacity to reproduce, according to an article published in the American Journal of Botany describing a study of this mechanism in Chamaecrista latistipula, a legume bel.....»»
Shedding light on a decades-old protein sorting mystery
Christian de Caestecker, a Ph.D. student in the lab of Ian Macara, Louise B. McGavock Professor and chair of the Department of Cell and Developmental Biology, has proposed and validated a mechanism that addresses a decades-old mystery surrounding epi.....»»
AI trained on evolution"s playbook develops proteins that spur drug and scientific discovery
A new artificial intelligence model developed by researchers at The University of Texas at Austin paves the way for more effective and less toxic treatments and new preventive strategies in medicine. The AI model informs the design of protein-based t.....»»
Biologists sequence proteins by pulling them through nanopores
A team of chemical biologists at the University of Washington, working with colleagues at Oxford Nanopore Technologies, has developed a protein sequencing process that involves pulling proteins through nanopores in a lipid membrane. Their paper is pu.....»»
Chevy woos Equinox EV buyers with Erewhon juice giveaway
Chevy is giving bottles of an electric-blue protein drink to people who test-drive an Equinox EV at an Erewhon organic market in L.A......»»
Improving industrial scale lactoferrin production with synthetic biological systems
Lactoferrin (LF), a multifunctional glycoprotein of the transferrin family, is naturally expressed in human and cow milk. The name "LF" is derived from its ability to bind to iron (ferrin, a suffix indicating iron-binding protein)......»»
Strategies for maximizing recombinant protein production in tobacco plants
Plant molecular farming (PMF) is a modern, sophisticated technology that utilizes plants' biosynthetic machinery to synthesize a plethora of recombinant proteins, including industrial and therapeutic enzymes. It has several advantages over traditiona.....»»
Naked mole-rat found to have lost infection-resistant proteins
Scientists have found that the naked mole-rat—an underground rodent that lives up to 40 years—has lost a number of CD1 functional genes. The CD1 gene family in mammals is responsible for protein synthesis that protects the body against infectious.....»»
Mechanism behind autophagy trigger unveiled
An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged components. In recent years, autophagy has also been.....»»
Guardsquare strenghtens mobile application security for developers
Guardsquare announced an innovative, guided approach to mobile application security that empowers teams to achieve the highest level of protection – now in the easiest possible way. Mobile development teams are now able to achieve a fully prote.....»»
Increasing protein in staple crops could help alleviate global protein shortage
A Mississippi State biologist's research in improving global nutrition and sustainability is featured this week in New Phytologist......»»
From chaos to order: Proteins can re-structure themselves to create important substances
The protein "MIPS" changes its internal structure when it becomes active. Its disordered active center becomes a defined structure with special functions. The protein plays a key role in the production of inositol, which is also known as vitamin B8,.....»»
New biosensor illuminates physiological signals in living animals
Eric Schreiter and Luke Lavis thought they had figured it out. In 2021, the Janelia group leaders reported that they had developed a way to combine Schreiter's engineered protein biosensors and Lavis's bright, fluorescent Janelia Fluor dyes......»»
New method developed to relocate misplaced proteins in cells
Cells are highly controlled spaces that rely on every protein being in the right place. Many diseases, including cancers and neurodegenerative disorders, are associated with misplaced proteins. In some cancers, for instance, a protein that normally s.....»»
Lucid eyes Detroit engineering talent ahead of EV launches, powertrain supply agreements
Lucid Motors opened a hub near Detroit to attract vehicle engineers. It also wants to provide its powertrain tech to more automakers......»»