Converting P450 peroxygenase into peroxidase via mechanism-guided protein engineering
Enzyme catalysis is a promising green solution for producing pharmaceuticals, fine chemicals, and biofuels. However, exploring their catalytic promiscuity to expand and enhance the capabilities of enzymes remains challenging......»»
x64dbg: Open-source binary debugger for Windows
x64dbg is an open-source binary debugger for Windows, designed for malware analysis and reverse engineering of executables without access to the source code. It offers a wide range of features and a plugin system, allowing you to customize and extend.....»»
Exploring Huntington"s disease: Researchers discover that protein aggregates poke holes in the nuclear membrane
Researchers at Utrecht University in the Netherlands have identified a new way in which the toxic protein aggregates associated with Huntington's disease may damage nerve cells and cause them to die......»»
Newly discovered protein stops DNA damage
Researchers from Western University have discovered a protein that has the never-before-seen ability to stop DNA damage in its tracks. The finding could provide the foundation for developing everything from vaccines against cancer, to crops that can.....»»
Surprise finding in study of environmental bacteria could advance search for better antibiotics
In what they labeled a "surprising" finding, Johns Hopkins Medicine researchers studying bacteria from freshwater lakes and soil say they have determined a protein's essential role in maintaining the germ's shape. Because the integrity of a bacterial.....»»
Harnessing compact RNA-guided endonucleases for enhanced genome editing
The review paper "CRISPR Beyond: Harnessing Compact RNA-Guided Endonucleases for Enhanced Genome Editing," authored by Feizuo Wang from National University of Singapore, presents a comprehensive examination of the advancements in CRISPR-Cas technolog.....»»
AI, computation, and the folds of life: Supercomputers help train a software tool for the protein modeling community
Form follows function, and this is especially true for life's building blocks—proteins. The folds and shape of molecular proteins reveal their function in supporting life......»»
Study finds protein reduces toxicity of graphene oxide for drug delivery
A new study has discovered ways to reduce the toxicity of graphene oxide (GO), an ultra-thin sheet of nanomaterial derived from graphite, laying the groundwork to use it as a drug delivery system......»»
International team discovers key protein that helps cells maintain their identity
A discovery regarding Mrc1 (Mediator of Replication Checkpoint 1)—a fission yeast protein involved in DNA replication—has been published in Cell. The discovery is the result of an international research collaboration, led by Professors Genevieve.....»»
Researchers identify body"s "quality control" regulator for protein folding, could lead to targeted treatments
Anyone who's tried to neatly gather a fitted sheet can tell you: folding is hard. Get it wrong with your laundry and the result can be a crumpled, wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins with an origami-.....»»
Developing a simple, cost-effective method to identify the targets of a crucial protein-modifying enzyme
Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at EMBL Grenoble have developed a new method to study a.....»»
Align or die: Revealing unknown mechanism essential for bacterial cell division
A previously unknown mechanism of active matter self-organization essential for bacterial cell division follows the motto "dying to align": Misaligned filaments "die" spontaneously to form a ring structure at the center of the dividing cell. The stud.....»»
Steps to improve quality engineering and system robustness
Major tech outages have recently impacted customers and operations at McDonald’s, Greggs, Deliveroo, Tesco, and Barclays. In this Help Net Security video, Stephen Johnson, CEO of Roq, says it is now imperative for companies and organizations to.....»»
Researchers discover new material for optically-controlled magnetic memory
Researchers at the University of Chicago Pritzker School of Molecular Engineering (PME) have made unexpected progress toward developing a new optical memory that can quickly and energy-efficiently store and access computational data. While studying a.....»»
Researchers discover new mechanism to cool buildings while saving energy
With temperatures rising globally, the need for more sustainable cooling options is also growing. Researchers at UCLA and their colleagues have now found an affordable and scalable process to cool buildings in the summer and heat them in the winter......»»
A new mechanism for shaping animal tissues
A key question that remains in biology and biophysics is how three-dimensional tissue shapes emerge during animal development. Research teams from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden, Germany, the Exce.....»»
The molecular shield: How tea plants combat drought through protein phosphorylation
Drought stress poses a significant challenge to agriculture, causing substantial yield losses in many crops. Tea plants, known for their rich flavonoid content which enhances both quality and health benefits, are particularly affected. Under drought.....»»
Powering enzymes with light to make ammonia
The Earth's atmosphere contains large amounts of nitrogen in the form of dinitrogen gas (N2). Converting N2 to ammonia (NH3) is critical for making the fertilizer needed for agriculture......»»
Researchers develop AI model that predicts the accuracy of protein–DNA binding
A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance that promises to reduce the t.....»»
New ligand-guided technique enhances drug development
Achieving a level of precision to create complex medicines and materials with extreme accuracy is a longstanding goal of scientists and pharmaceutical companies. If achieved, that precision could lead to the development of more effective drug treatme.....»»
Study reveals mechanism used by tegu lizard to raise own temperature
A group of scientists has revealed the mechanism whereby Salvator merianae—the black and white tegu, also called the Argentine giant tegu—is able to keep warm by raising its own body temperature during the reproductive season even while it is in.....»»