Converting P450 peroxygenase into peroxidase via mechanism-guided protein engineering
Enzyme catalysis is a promising green solution for producing pharmaceuticals, fine chemicals, and biofuels. However, exploring their catalytic promiscuity to expand and enhance the capabilities of enzymes remains challenging......»»
Biomass-based polymer can capture and release CO₂ without high pressure or extreme temperatures
A new, biomass-based material developed by FAMU-FSU College of Engineering researchers can be used to repeatedly capture and release carbon dioxide......»»
Dual protein analysis approach provides potential way to slow cancer growth
Fighting cancer effectively often involves stopping cancer cells from multiplying, which requires understanding proteins that the cells rely on to survive. Protein profiling plays a critical role in this process by helping researchers identify protei.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
Researchers discover rejuvenation mechanism in unicellular organisms
A team of scientists from the Cluster of Excellence "Balance of the Microverse" has discovered a previously unknown rejuvenation mechanism in unicellular organisms. They studied unicellular microalgae, which serve as the basis of food chains in the o.....»»
Researchers develop high-entropy non-covalent cyclic peptide glass for smart functional materials
Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed a sustainable, biodegradable, biorecyclable material: high-entropy non-covalent cyclic peptide (HECP) glass. This innovative glass features.....»»
Accurate deformation monitoring—the era of dual-base station technology
Deformation monitoring plays a vital role in geological disaster management, transportation, and engineering maintenance. While Global Navigation Satellite System (GNSS) relative positioning has been the standard for such tasks, its precision often f.....»»
Extreme rainfall event study demonstrates improved forecasting via physics-guided machine learning
A research team focused on the extreme rainfall event of "21·7" in Henan in 2021. By analyzing anomalous physical characteristics and understanding multi-model forecast biases, they significantly enhanced the accuracy of precipitation intensity fore.....»»
Scientists discover novel receptor recognition mechanism for alphavirus
Eastern Equine Encephalitis virus (EEEV), an alphavirus, can cause central nervous system infections that can lead to severe encephalitis with a mortality rate of over 30%......»»
Research unravels dual role of membrane protein in rice ethylene signal transduction
A research team, led by Professor Zhang Jinsong from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences, revealed insights into the mechanism by which the membrane protein MHZ3 collaborates with the ethylene.....»»
Single nucleosomes tracked in live cells during cell division using super-resolution microscopy
Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism by which DNA condenses during mitosis is still poor.....»»
A small molecular glue that increases P53 level and suppresses tumor growth in vivo
Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, and there has been a lac.....»»
Cryo-ET study elucidates protein folding helpers in their natural environment
Cryo-electron tomography (cryo-ET), can be used to visualize and analyze cellular structures in their natural environment. Researchers at the MPI of Biochemistry in Martinsried and the University Medical Center Göttingen have now used cryo-ET to stu.....»»
Self-repairing mitochondria use novel recycling system, study finds
Mitochondria depend on a newly discovered recycling mechanism identified by scientists at The Hospital for Sick Children (SickKids)......»»
Surprising mechanism for removing dead cells identified
Billions of our cells die every day to make way for the growth of new ones. Most of these goners are cleaned up by phagocytes—mobile immune cells that migrate where needed to engulf problematic substances. But some dying or dead cells are consumed.....»»
Comparing methods for extracting edible protein from mealworms
Edible insects are emerging as an alternative protein source that has various benefits compared with conventional animal sources. New research published in the Journal of Food Science compared four different methods for extracting protein from mealwo.....»»
Researchers teach artificial intelligence about frustration in protein folding
Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial intelligence (AI) technology has made it possible to predict.....»»
Habitat connectivity drives panda recovery, finds study
In a study published in Current Biology on August 9, a research team led by Prof. Wei Fuwen from Jiangxi Agricultural University and the Institute of Zoology of the Chinese Academy of Sciences, revealed the mechanism and process of giant panda (Ailur.....»»
Novel ratchet mechanism uses a geometrically symmetric gear driven by asymmetric surface wettability
The ratchet mechanism is a fascinating energy-conversion system that converts disorderly or random motion into orderly, directed movement through a process known as spontaneous rectification. It is a critical component of mechanical systems, typicall.....»»
Physicists successfully observe Kibble–Zurek scaling in an atomic Fermi superfluid
The Kibble–Zurek (KZ) mechanism is a theoretical framework introduced by physicists Tom Kibble and Wojciech Zurek. This framework essentially describes the formation of topological defects while systems undergo non-equilibrium phase transitions......»»
New bacteria-derived hydrogel shows promise for muscle tissue regeneration
A research team at the Technical University of Denmark, led by Alireza Dolatshahi-Pirouz, has recently made strides in tissue engineering and cell therapy by harnessing the healing power of bacteria......»»