Better understanding of cellular metabolism with the help of AI
Metabolism is essential to all living organisms, and modeling the chemical reactions that sustain life is no easy task. Now, EPFL scientists have released REKINDLE, a deep-learning process that is paving the way for more efficient and accurate modeli.....»»
AI tool maps out cell metabolism with precision
Understanding how cells process nutrients and produce energy—collectively known as metabolism—is essential in biology. Modern biology generates large datasets on various cellular activities, but integrating and analyzing the vast amounts of data.....»»
Light-activated polymerization methods unlock new possibilities for intracellular applications
Synthetic polymers play a crucial role in cell biology, serving as delivery vehicles for DNA and drugs, acting as fluorescent probes for cellular sensing, functioning as bioinks for tissue engineering, and mimicking biological functionality (e.g., ar.....»»
How a salt giant radically reshaped Mediterranean marine biodiversity
A new study paves the way to understanding biotic recovery after an ecological crisis in the Mediterranean Sea about 5.5 million years ago. An international team led by Konstantina Agiadi from the University of Vienna has now been able to quantify ho.....»»
Shedding light on the mechanism of yeast DNA repair
DNA damage is a cellular phenomenon that introduces structural abnormalities in double-stranded DNA. External factors, such as radiation or chemical agents, as well as internal factors, such as blocked DNA replication, can generate double-strand brea.....»»
Protein mutant stability can be inferred from AI-predicted structures
Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI......»»
Upgraded atomic force microscope captures 3D images of calcite dissolving
Understanding the dissolution processes of minerals can provide key insights into geochemical processes. Attempts to explain some of the observations during the dissolution of calcite (CaCO3) have led to the hypothesis that a hydration layer forms, a.....»»
Supercomputer simulations reveal the nature of turbulence in black hole accretion disks
Researchers at Tohoku University and Utsunomiya University have made a breakthrough in understanding the complex nature of turbulence in structures called accretion disks surrounding black holes, using state-of-the-art supercomputers to conduct the h.....»»
Scientists develop new chemical tool for infection research
Researchers from Würzburg and Berlin present a new molecule for visualizing the sphingomyelin metabolism. This offers prospects for innovative therapeutic approaches in infection research. The work is published in the journal Nature Communications......»»
Uncertainty is a key factor in the relationship between work injury and mental health, research shows
Mental health and workplace injuries are known to be closely linked, but there are significant gaps in our deeper understanding of that bidirectional relationship. How does one affect the other, what moderates the relationship and what are the long-t.....»»
Simulation model shows ribosome tunnel"s impact on protein structures
Researchers at University of Tsukuba have developed a new model that simulates the internal environment of a ribosome—the cellular site of protein synthesis. Using computer simulations, they have analyzed the structures of various proteins within t.....»»
Light microscopy study reveals molecular density changes during mitotic chromosome condensation
A team of scientists studying cell division developed a special light microscopy system and used it to analyze the molecular density of cellular environments. Their results provide a novel insight into mitotic chromosome condensation in living human.....»»
Cold math, hot topic: Applied theory offers new insights into sea ice thermal conductivity
A new applied mathematical theory could enhance our understanding of how sea ice affects global climate, potentially improving the accuracy of climate predictions......»»
Population genetic insights into the conservation of common walnut (Juglans regia) in Central Asia
Understanding species distribution, differentiation and the factors affecting genetic diversity is important for sustainable conservation and effective management, as well as the rational utilization of species germplasm......»»
Toyota, BMW to upgrade fuel cell alliance, report says
BMW and Toyota plan to sign a memorandum of understanding for the partnership next week, with an official announcement set for Sept. 5, Nikkei Asia reported......»»
Half of enterprises suffer breaches despite heavy security investments
Data breaches have become an increasingly severe threat, with recent reports highlighting a surge in their frequency and cost. Understanding the latest trends and statistics surrounding data breaches is essential for developing effective strategies t.....»»
Dual protein analysis approach provides potential way to slow cancer growth
Fighting cancer effectively often involves stopping cancer cells from multiplying, which requires understanding proteins that the cells rely on to survive. Protein profiling plays a critical role in this process by helping researchers identify protei.....»»
Scientists use evolution to bioengineer new pathways to sustainable energy and pharmaceuticals
Using evolution as a guiding principle, researchers have successfully engineered bacteria-yeast hybrids to perform photosynthetic carbon assimilation, generate cellular energy and support yeast growth without traditional carbon feedstocks like glucos.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
Discovery of a hidden epigenetic clock in mitochondria reveals a "lifespan limit line"
Building on their work on epigenetics of aging and transposable elements, researchers Dr. Ádám Sturm and Dr. Tibor Vellai from Eötvös Loránd University have made another advance in understanding the molecular mechanisms of aging. Their latest st.....»»
A hybrid arrowhead against immune disorders: Bacterially derived natural product inhibits cellular immune response
The so-called immunoproteasome is essential for the cellular immune response. In autoimmune diseases, however, it is overactive. Until now, it has not been possible to selectively inhibit the immunoproteasome without disrupting other cellular mechani.....»»